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Aliases for HAND2-AS1 Gene
Data sources for HAND2-AS1 Gene:
Subcategory (RNA class) for HAND2-AS1 Gene
lncRNA
Aliases for HAND2-AS1 Gene
- HAND2 Antisense RNA 1 (HGNC, NCBI Entrez Gene, Ensembl)
- Differentially Expressed In Neuroblastoma (HGNC, NCBI Entrez Gene)
- HAND2 Antisense RNA 1 (Head To Head) (HGNC, NCBI Entrez Gene)
- Neuroblastoma Transcript 301 (HGNC, NCBI Entrez Gene)
- NBLA00301 (HGNC, NCBI Entrez Gene)
- HAND2-AS1 (Ensembl, LNCipedia)
- DEIN (HGNC, NCBI Entrez Gene)
External Ids for HAND2-AS1 Gene
- HGNC: 48872
- NCBI Entrez Gene: 79804
- Ensembl: ENSG00000237125
- OMIM®: 617240
Previous GeneCards Identifiers for HAND2-AS1 Gene
- GC04P174448
Summaries for HAND2-AS1 Gene
GeneCards Summary for HAND2-AS1 Gene
HAND2-AS1 (HAND2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HAND2-AS1 include Lmna-Related Dilated Cardiomyopathy and Cardiomyopathy, Dilated, 1A.
Additional gene information for HAND2-AS1 Gene
- HGNC (48872)
- NCBI Entrez Gene (79804)
- Ensembl (ENSG00000237125)
- OMIM® (617240)
- Open Targets Platform(ENSG00000237125)
- Search for HAND2-AS1 at DataMed
- Search for HAND2-AS1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HAND2-AS1 Gene
Genomics for HAND2-AS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HAND2-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HAND2-AS1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for HAND2-AS1 Gene
Latest Assembly
- chr4:173,527,270-173,671,467
- (GRCh38/hg38)
- Size:
- 144,198 bases
- Orientation:
- Plus strand
Previous Assembly
- chr4:174,449,751-174,512,406
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 62,656 bases
- Orientation:
- Plus strand
- chr4:174,448,421-174,512,475
- (GRCh37/hg19 by Ensembl)
- Size:
- 64,055 bases
- Orientation:
- Plus strand
Genomic View for HAND2-AS1 Gene
Genes around HAND2-AS1 on UCSC Golden Path with GeneCards custom track
HAND2-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 4q34.1 by HGNC
- 4q34.1 by Entrez Gene
- 4q34.1 by Ensembl
HAND2-AS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HAND2-AS1 Gene
Proteins for HAND2-AS1 Gene
Post-translational modifications for HAND2-AS1 Gene
No Post-translational modifications
No data available for DME Specific Peptides for HAND2-AS1 Gene
Domains & Families for HAND2-AS1 Gene
Gene Families for HAND2-AS1 Gene
- HGNC:
Suggested Antigen Peptide Sequences for HAND2-AS1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ11539 fis, clone HEMBA1002748 (Q9HAJ2_HUMAN)
No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HAND2-AS1 Gene
Function for HAND2-AS1 Gene
Phenotypes From GWAS Catalog for HAND2-AS1 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HAND2-AS1 - Starting at $85 >
- * HAND2-AS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
- Origene shrna and RNAi products in human, mouse, rat for HAND2-AS1
- Browse OriGene Inhibitory RNA Products For HAND2-AS1
Clone products for research
- Applied Biological Materials (abm): Clones for HAND2-AS1 - Starting at $45 >
- * HAND2-AS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAND2-AS1 Gene
Localization for HAND2-AS1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HAND2-AS1 Gene
Transcripts for HAND2-AS1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for HAND2-AS1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00002C5C5A_9606 | lncRNA | 3408 | 4 |
Ensembl: ENST00000510339 (view in UCSC) , LncBook: HSALNT0080953, LNCipedia: HAND2-AS1:6, NONCODE: NONHSAT099268.2, |
| URS0000228B1D_9606 | lncRNA | 3277 | 4 |
Ensembl: ENST00000515350 (view in UCSC) , LncBook: HSALNT0080954, LNCipedia: HAND2-AS1:17, NONCODE: NONHSAT099264.2, |
| URS00002D44CF_9606 | lncRNA | 3196 | 4 |
Ensembl: ENST00000507571 (view in UCSC) , LncBook: HSALNT0080950, LNCipedia: HAND2-AS1:10, NONCODE: NONHSAT099266.2, |
| URS000043F129_9606 | lncRNA | 3148 | 4 |
Ensembl: ENST00000508534 (view in UCSC) , LncBook: HSALNT0080952, LNCipedia: HAND2-AS1:11, NONCODE: NONHSAT099274.2, |
| URS000035686F_9606 | lncRNA | 951 | 4 |
Ensembl: ENST00000515376 (view in UCSC) , LncBook: HSALNT0080956, LNCipedia: HAND2-AS1:23, NONCODE: NONHSAT099277.2, |
HAND2-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for HAND2-AS1 Gene
- 38 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HAND2-AS1 - Starting at $85 >
- * HAND2-AS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
- Origene shrna and RNAi products in human, mouse, rat for HAND2-AS1
- Browse OriGene Inhibitory RNA Products For HAND2-AS1
Clone products for research
- Applied Biological Materials (abm): Clones for HAND2-AS1 - Starting at $45 >
- * HAND2-AS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for HAND2-AS1 Gene
- GeneLoc Exon Structure for
- HAND2-AS1
Expression for HAND2-AS1 Gene
mRNA differential expression in normal tissues according to GTEx for HAND2-AS1 Gene
This gene is overexpressed in Colon - Sigmoid (x9.3) and Uterus (x4.7).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HAND2-AS1
Primer products for research
-
OriGene qPCR primer pairs for HAND2-AS1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAND2-AS1 Gene
Orthologs for HAND2-AS1 Gene
No data available for Orthologs for HAND2-AS1 Gene
Paralogs for HAND2-AS1 Gene
No data available for Paralogs for HAND2-AS1 Gene
Variants for HAND2-AS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HAND2-AS1 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1553974835 | Pathogenic: Dilated cardiomyopathy 1A | 173,529,091(+) |
C/A NM_021973.3(HAND2):c.199G>T (p.Glu67Ter) |
NONSENSE | |
| rs483353128 | Likely Pathogenic: not provided | 173,528,900(+) |
G/T NM_021973.3(HAND2):c.390C>A (p.Pro130=) |
SYNONYMOUS | |
| rs758014710 | Likely Benign: not provided | 173,529,176(+) |
C/T NM_021973.3(HAND2):c.114G>A (p.Glu38=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for HAND2-AS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HAND2-AS1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HAND2-AS1 Gene
Disorders for HAND2-AS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lmna-related dilated cardiomyopathy |
|
|
| cardiomyopathy, dilated, 1a |
|
|
| cardiomyopathy, dilated, 1h |
|
|
| right ventricular hypoplasia, isolated |
|
|
| dilated cardiomyopathy |
|
|
Search HAND2-AS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HAND2-AS1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HAND2-AS1 Gene
Publications for HAND2-AS1 Gene
- Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. (PMID: 29107108) Yang X … Kwong J (Cancer letters 2018) 3 74
- Recurrently deregulated lncRNAs in hepatocellular carcinoma. (PMID: 28194035) Yang Y … Lu ZJ (Nature communications 2017) 2 3
- Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma. (PMID: 19348682) Voth H … Fischer M (BMC molecular biology 2009) 2 3
- Identification of DEIN, a novel gene with high expression levels in stage IVS neuroblastoma. (PMID: 18171985) Voth H … Fischer M (Molecular cancer research : MCR 2007) 2 3
- Screening of significant biomarkers related with prognosis of liver cancer by lncRNA-associated ceRNAs analysis. (PMID: 31502679) He J … Xu Z (Journal of cellular physiology 2020) 3
Products for HAND2-AS1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HAND2-AS1
- Origene Custom Protein Services for HAND2-AS1
- Origene shrna and RNAi products in human, mouse, rat for HAND2-AS1
- Browse OriGene Inhibitory RNA Products For HAND2-AS1
- OriGene qPCR primer pairs for HAND2-AS1
- Browse CRISPR knockouts for HAND2-AS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HAND2-AS1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for HAND2-AS1 (AFLGC-HAND2-AS1)
- antibodies-online: Search results for available HAND2-AS1 related products ranked by validation data
- antibodies-online: Search results for available HAND2-AS1 related products ranked by validation data
- antibodies-online: Search results for available HAND2-AS1 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for HAND2-AS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for HAND2-AS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HAND2-AS1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for HAND2-AS1
Sources for HAND2-AS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB