Aliases for HAND2-AS1 Gene

Data sources for HAND2-AS1 Gene:

Subcategory (RNA class) for HAND2-AS1 Gene

lncRNA

Aliases for HAND2-AS1 Gene

External Ids for HAND2-AS1 Gene

Previous GeneCards Identifiers for HAND2-AS1 Gene

  • GC04P174448

Summaries for HAND2-AS1 Gene

GeneCards Summary for HAND2-AS1 Gene

HAND2-AS1 (HAND2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HAND2-AS1 include Lmna-Related Dilated Cardiomyopathy and Cardiomyopathy, Dilated, 1A.

Additional gene information for HAND2-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HAND2-AS1 Gene

Genomics for HAND2-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HAND2-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J173520 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 260.7 +0.7 697 14.1 TBP SMAD5 SIN3A VEZF1 GABPA TAL1 YY1 PRDM10 SUPT5H CBX8 HAND2-AS1 HAND2 SCRG1 lnc-HAND2-2 lnc-SAP30-21
GH04J174120 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +593.0 593031 1 MNT IKZF1 HES1 CTCF BHLHE40 MCM3 REST NBN TRIM22 SMC3 LINC02268 CEP44 HMGB2 ENSG00000261646 HAND2-AS1 lnc-CEP44-2 LOC107986204 HSALNG0038627 FBXO8 lnc-CEP44-7
GH04J173417 Enhancer 0.9 ENCODE 10.2 -110.1 -110075 0.2 MNT IKZF1 ZNF217 CTCF MCM7 MCM3 ARNT REST NFATC3 ZNF639 HMGB2 CEP44 ENSG00000261646 HAND2-AS1 RPL5P11 lnc-SAP30-11 SAP30 SCRG1
GH04J173547 Enhancer 0.7 dbSUPER 12.5 +20.6 20587 1.3 MAFF ZNF316 FOSL1 SPI1 NFE2 MAFG ATF4 SP7 BACH1 CEBPB HAND2-AS1 RNU6-1096P HAND2 RF00017-4456 FBXO8
GH04J173447 Enhancer 1.2 VISTA Ensembl ENCODE 6.7 -78.4 -78401 5.1 FEZF1 MAFF TAL1 ZNF843 JUND ZNF316 FOSL1 NFE2 BATF HDAC2 HSALNG0038601 HAND2-AS1 ENSG00000286226 RF00026-839 RNU6-1096P SCRG1 SAP30
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAND2-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for HAND2-AS1 Gene

Latest Assembly
chr4:173,527,270-173,671,467
(GRCh38/hg38)
Size:
144,198 bases
Orientation:
Plus strand

Previous Assembly
chr4:174,449,751-174,512,406
(GRCh37/hg19 by Entrez Gene)
Size:
62,656 bases
Orientation:
Plus strand

chr4:174,448,421-174,512,475
(GRCh37/hg19 by Ensembl)
Size:
64,055 bases
Orientation:
Plus strand

Genomic View for HAND2-AS1 Gene

Genes around HAND2-AS1 on UCSC Golden Path with GeneCards custom track
HAND2-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
HAND2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAND2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAND2-AS1 Gene

Proteins for HAND2-AS1 Gene

Post-translational modifications for HAND2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HAND2-AS1 Gene

Domains & Families for HAND2-AS1 Gene

Gene Families for HAND2-AS1 Gene

Suggested Antigen Peptide Sequences for HAND2-AS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ11539 fis, clone HEMBA1002748 (Q9HAJ2_HUMAN)
genes like me logo Genes that share domains with HAND2-AS1: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HAND2-AS1 Gene

Function for HAND2-AS1 Gene

Phenotypes From GWAS Catalog for HAND2-AS1 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAND2-AS1 Gene

Localization for HAND2-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAND2-AS1 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HAND2-AS1 Gene

Pathways & Interactions for HAND2-AS1 Gene

PathCards logo

SuperPathways for HAND2-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAND2-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for HAND2-AS1 Gene

Drugs & Compounds for HAND2-AS1 Gene

No Compound Related Data Available

Transcripts for HAND2-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for HAND2-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002C5C5A_9606 lncRNA 3408 4

Ensembl: ENST00000510339 (view in UCSC) ,

LncBook: HSALNT0080953,

LNCipedia: HAND2-AS1:6,

NONCODE: NONHSAT099268.2,

URS0000228B1D_9606 lncRNA 3277 4

Ensembl: ENST00000515350 (view in UCSC) ,

LncBook: HSALNT0080954,

LNCipedia: HAND2-AS1:17,

NONCODE: NONHSAT099264.2,

URS00002D44CF_9606 lncRNA 3196 4

Ensembl: ENST00000507571 (view in UCSC) ,

LncBook: HSALNT0080950,

LNCipedia: HAND2-AS1:10,

NONCODE: NONHSAT099266.2,

URS000043F129_9606 lncRNA 3148 4

Ensembl: ENST00000508534 (view in UCSC) ,

LncBook: HSALNT0080952,

LNCipedia: HAND2-AS1:11,

NONCODE: NONHSAT099274.2,

URS000035686F_9606 lncRNA 951 4

Ensembl: ENST00000515376 (view in UCSC) ,

LncBook: HSALNT0080956,

LNCipedia: HAND2-AS1:23,

NONCODE: NONHSAT099277.2,

HAND2-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for HAND2-AS1 Gene

38 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for HAND2-AS1 Gene

No ASD Table

Relevant External Links for HAND2-AS1 Gene

GeneLoc Exon Structure for
HAND2-AS1

Expression for HAND2-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HAND2-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for HAND2-AS1 Gene

This gene is overexpressed in Colon - Sigmoid (x9.3) and Uterus (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HAND2-AS1

genes like me logo Genes that share expression patterns with HAND2-AS1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAND2-AS1 Gene

Orthologs for HAND2-AS1 Gene

Evolution for HAND2-AS1 Gene

ENSEMBL:
Gene Tree for HAND2-AS1 (if available)
TreeFam:
Gene Tree for HAND2-AS1 (if available)

No data available for Orthologs for HAND2-AS1 Gene

Paralogs for HAND2-AS1 Gene

No data available for Paralogs for HAND2-AS1 Gene

Variants for HAND2-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HAND2-AS1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1553974835 Pathogenic: Dilated cardiomyopathy 1A 173,529,091(+) C/A
NM_021973.3(HAND2):c.199G>T (p.Glu67Ter)
NONSENSE
rs483353128 Likely Pathogenic: not provided 173,528,900(+) G/T
NM_021973.3(HAND2):c.390C>A (p.Pro130=)
SYNONYMOUS
rs758014710 Likely Benign: not provided 173,529,176(+) C/T
NM_021973.3(HAND2):c.114G>A (p.Glu38=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HAND2-AS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HAND2-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv518998 CNV loss 19592680
nsv522261 CNV loss 19592680

Additional Variant Information for HAND2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAND2-AS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HAND2-AS1 Gene

Disorders for HAND2-AS1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HAND2-AS1 Gene - From: LNC, CVR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HAND2-AS1

genes like me logo Genes that share disorders with HAND2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HAND2-AS1 Gene

Publications for HAND2-AS1 Gene

  1. Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. (PMID: 29107108) Yang X … Kwong J (Cancer letters 2018) 3 74
  2. Recurrently deregulated lncRNAs in hepatocellular carcinoma. (PMID: 28194035) Yang Y … Lu ZJ (Nature communications 2017) 2 3
  3. Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma. (PMID: 19348682) Voth H … Fischer M (BMC molecular biology 2009) 2 3
  4. Identification of DEIN, a novel gene with high expression levels in stage IVS neuroblastoma. (PMID: 18171985) Voth H … Fischer M (Molecular cancer research : MCR 2007) 2 3
  5. Screening of significant biomarkers related with prognosis of liver cancer by lncRNA-associated ceRNAs analysis. (PMID: 31502679) He J … Xu Z (Journal of cellular physiology 2020) 3

Products for HAND2-AS1 Gene

Sources for HAND2-AS1 Gene