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Aliases for HAND2-AS1 Gene

Subcategory (RNA class) for HAND2-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for HAND2-AS1 Gene

  • HAND2 Antisense RNA 1 2 3 5
  • Differentially Expressed In Neuroblastoma 2 3
  • HAND2 Antisense RNA 1 (Head To Head) 2 3
  • Neuroblastoma Transcript 301 2 3
  • NBLA00301 3
  • DEIN 3
  • UPH 3

External Ids for HAND2-AS1 Gene

Previous GeneCards Identifiers for HAND2-AS1 Gene

  • GC04P174448

Summaries for HAND2-AS1 Gene

GeneCards Summary for HAND2-AS1 Gene

HAND2-AS1 (HAND2 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HAND2-AS1 include Right Ventricle Hypoplasia and Endometrial Cancer.

Additional gene information for HAND2-AS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAND2-AS1 Gene

Genomics for HAND2-AS1 Gene

GeneHancer (GH) Regulatory Elements for HAND2-AS1 Gene

Promoters and enhancers for HAND2-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J173520 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 610.7 +1.6 1597 15.9 CBFA2T2 ZNF148 YY1 POLR2A ZBTB8A ATF1 CTCF ZEB2 SP1 ZNF629 HAND2-AS1 HAND2 SCRG1 GC04M173250
GH04J173414 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.2 -110.5 -110536 1.1 MTA3 CC2D1A CTCF MLLT1 GTF2F1 CSDE1 ZSCAN21 CDC5L MCM2 SP7 SCRG1 CEP44 ENSG00000261646 HMGB2 HAND2-AS1 SAP30 RPL5P11 LOC101928383 GC04M173250
GH04J174120 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 10.1 +593.0 593031 1.4 CC2D1A CTCF NCOA6 SP7 PRDM1 ZNF384 EGR1 MTA1 IKZF1 GMEB1 LINC02268 CEP44 HMGB2 ENSG00000261646 HAND2-AS1 GC04P174110 ENSG00000250957
GH04J173547 Promoter/Enhancer 1.2 Ensembl dbSUPER 12.5 +20.8 20831 0.6 BACH1 TRIM24 SP7 SMARCA4 RNF2 ZNF316 MGA MAFK NFE2 HDAC2 HAND2-AS1 RNU6-1096P HAND2 GC04P173594 GC04M173250
GH04J173538 Promoter/Enhancer 1.2 Ensembl dbSUPER 7.6 +11.3 11331 1.6 PRDM1 MZF1 GLIS2 PRDM10 ZIC2 POLR2A PATZ1 ZNF341 EZH2 BMI1 CEP44 ENSG00000261646 HAND2-AS1 HAND2 GC04P173594 GC04M173250
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HAND2-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HAND2-AS1 Gene

Genomic Locations for HAND2-AS1 Gene
chr4:173,527,270-173,659,696
(GRCh38/hg38)
Size:
132,427 bases
Orientation:
Plus strand
chr4:174,448,421-174,512,475
(GRCh37/hg19)
Size:
64,055 bases
Orientation:
Plus strand

Genomic View for HAND2-AS1 Gene

Genes around HAND2-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAND2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAND2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAND2-AS1 Gene

Proteins for HAND2-AS1 Gene

Post-translational modifications for HAND2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HAND2-AS1 Gene

Domains & Families for HAND2-AS1 Gene

Gene Families for HAND2-AS1 Gene

Suggested Antigen Peptide Sequences for HAND2-AS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ11539 fis, clone HEMBA1002748 (Q9HAJ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HAND2-AS1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for HAND2-AS1 Gene

Function for HAND2-AS1 Gene

Phenotypes From GWAS Catalog for HAND2-AS1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAND2-AS1 Gene

Localization for HAND2-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HAND2-AS1 Gene

Pathways & Interactions for HAND2-AS1 Gene

PathCards logo

SuperPathways for HAND2-AS1 Gene

No Data Available

Interacting Proteins for HAND2-AS1 Gene

Gene Ontology (GO) - Biological Process for HAND2-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HAND2-AS1 Gene

Drugs & Compounds for HAND2-AS1 Gene

No Compound Related Data Available

Transcripts for HAND2-AS1 Gene

mRNA/cDNA for HAND2-AS1 Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAND2-AS1 Gene

No ASD Table

Relevant External Links for HAND2-AS1 Gene

GeneLoc Exon Structure for
HAND2-AS1
ECgene alternative splicing isoforms for
HAND2-AS1

Expression for HAND2-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAND2-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for HAND2-AS1 Gene

This gene is overexpressed in Colon - Sigmoid (x9.3) and Uterus (x4.7).
genes like me logo Genes that share expression patterns with HAND2-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAND2-AS1 Gene

Orthologs for HAND2-AS1 Gene

Evolution for HAND2-AS1 Gene

ENSEMBL:
Gene Tree for HAND2-AS1 (if available)
TreeFam:
Gene Tree for HAND2-AS1 (if available)

No data available for Orthologs for HAND2-AS1 Gene

Paralogs for HAND2-AS1 Gene

No data available for Paralogs for HAND2-AS1 Gene

Variants for HAND2-AS1 Gene

Sequence variations from dbSNP and Humsavar for HAND2-AS1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1553974835 pathogenic, Dilated cardiomyopathy 1A 173,529,091(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs483353128 likely-pathogenic, not provided 173,528,900(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000057185 -- 173,527,051(+) C/T upstream_transcript_variant
rs1000104805 -- 173,530,455(+) A/G genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000156515 -- 173,569,089(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HAND2-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv518998 CNV loss 19592680
nsv522261 CNV loss 19592680

Additional Variant Information for HAND2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAND2-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HAND2-AS1 Gene

Disorders for HAND2-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HAND2-AS1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
right ventricle hypoplasia
  • hypoplasia of the right ventricle
endometrial cancer
  • endometrial cancer, familial
squamous cell carcinoma, head and neck
  • hnscc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HAND2-AS1

genes like me logo Genes that share disorders with HAND2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HAND2-AS1 Gene

Publications for HAND2-AS1 Gene

  1. Recurrently deregulated lncRNAs in hepatocellular carcinoma. (PMID: 28194035) Yang Y … Lu ZJ (Nature communications 2017) 2 3 58
  2. Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma. (PMID: 19348682) Voth H … Fischer M (BMC molecular biology 2009) 2 3 58
  3. Identification of DEIN, a novel gene with high expression levels in stage IVS neuroblastoma. (PMID: 18171985) Voth H … Fischer M (Molecular cancer research : MCR 2007) 2 3 58
  4. Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. (PMID: 29107108) Yang X … Kwong J (Cancer letters 2018) 3 58
  5. LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14. (PMID: 30078677) Zhou J … Xie R (Biochemical and biophysical research communications 2018) 3 58

Products for HAND2-AS1 Gene

Sources for HAND2-AS1 Gene

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