Aliases for HACD4 Gene
External Ids for HACD4 Gene
Previous HGNC Symbols for HACD4 Gene
GeneCards Summary for HACD4 Gene
HACD4 (3-Hydroxyacyl-CoA Dehydratase 4) is a Protein Coding gene. Diseases associated with HACD4 include Spinocerebellar Ataxia 34. Among its related pathways are Metabolism and alpha-linolenic (omega3) and linoleic (omega6) acid metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and 3-hydroxyacyl-CoA dehydratase activity. An important paralog of this gene is HACD3.
UniProtKB/Swiss-Prot Summary for HACD4 Gene
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.