Aliases for HACD2 Gene
- 3-Hydroxyacyl-CoA Dehydratase 2 2 3 4 5
- Protein Tyrosine Phosphatase-Like (Proline Instead Of Catalytic Arginine), Member B 2 3
- Very-Long-Chain (3R)-3-Hydroxyacyl-CoA Dehydratase 2 2 3
- Protein-Tyrosine Phosphatase-Like Member B 3 4
- PTPLB 3 4
- Very-Long-Chain (3R)-3-Hydroxyacyl-[Acyl-Carrier Protein] Dehydratase 2 3
- EC 126.96.36.199 4
External Ids for HACD2 Gene
Previous HGNC Symbols for HACD2 Gene
The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]
GeneCards Summary for HACD2 Gene
HACD2 (3-Hydroxyacyl-CoA Dehydratase 2) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and lyase activity. An important paralog of this gene is HACD1.
UniProtKB/Swiss-Prot for HACD2 Gene
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.