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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
H4C9 (H4 Clustered Histone 9) is a Protein Coding gene. Diseases associated with H4C9 include Hyperoxaluria, Primary, Type I and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H4C5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027126 | Promoter/Enhancer | 2.5 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.6 | -566 | 23 | BRCA1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 | H4C9 H2BC11 ABT1 HMGN4 BTN2A2 BTN2A1 ZNF322 ENSG00000261584 BTN2A3P GUSBP2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,TAS | 3035717 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9540062 |
GO:0019904 | protein domain specific binding | IPI | 22368283 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0000786 | nucleosome | TAS | 3035717 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
GO:0006334 | nucleosome assembly | IBA,IDA | 20498094 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Hist1h4h 30 |
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H4c8 17 |
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Rat (Rattus norvegicus) |
Mammalia | Hist1h4a 30 |
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Cow (Bos Taurus) |
Mammalia | LOC527645 30 |
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Chimpanzee (Pan troglodytes) |
Mammalia | LOC748545 30 |
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Chicken (Gallus gallus) |
Aves | HIST1H46L4 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731642 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC794549 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | His4:CG33885 30 |
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Worm (Caenorhabditis elegans) |
Secernentea | his-14 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HIS4 30 |
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Rice (Oryza sativa) |
Liliopsida | Os09g0553100 30 |
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SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780599 | Benign: not provided | 27,139,614(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1029124 | CNV | loss | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperoxaluria, primary, type i |
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hyperinsulinemic hypoglycemia, familial, 1 |
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hyperinsulinemic hypoglycemia, familial, 2 |
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meier-gorlin syndrome 1 |
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carbohydrate metabolic disorder |
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