Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...

Aliases for H4C7 Gene

Aliases for H4C7 Gene

  • H4 Clustered Histone 7 2 3 5
  • H4/L 2 3 4
  • Histone Cluster 1 H4 Family Member G 2 3
  • Histone H4-Like Protein Type G 3 4
  • H4 Histone Family, Member L 2 3
  • Histone Cluster 1, H4g 2 3
  • Histone 1, H4g 2 3
  • HIST1H4G 3 4
  • H4FL 3 4
  • H4-Clustered Histone 7 4
  • H4C7 5

External Ids for H4C7 Gene

Previous HGNC Symbols for H4C7 Gene

  • H4FL
  • HIST1H4G

Previous GeneCards Identifiers for H4C7 Gene

  • GC06M026846
  • GC06M027066

Summaries for H4C7 Gene

Entrez Gene Summary for H4C7 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for H4C7 Gene

H4C7 (H4 Clustered Histone 7) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is H4C5.

UniProtKB/Swiss-Prot Summary for H4C7 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Gene Wiki entry for H4C7 Gene

Additional gene information for H4C7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4C7 Gene

Genomics for H4C7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for H4C7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J026245 Enhancer 0.3 Ensembl 600.7 +1.7 1695 0.2 MCM3 H4C7 BTN2A3P HMGN4 ABT1 ZNF322 BTN2A1 LINC00240 H4C6
GH06J026437 Enhancer 0.6 FANTOM5 10.4 -190.8 -190838 0.2 HMBOX1 E2F5 CEBPG NR2F6 ADNP CEBPB BRF2 MEIS2 GATA2 ATF1 BTN1A1 BTN2A2 BTN2A1 HMGN4 H4C7 H2AC10P BTN3A3 lnc-HIST1H4H-4 lnc-BTN3A1-1 BTN3A1
GH06J026005 Enhancer 0.8 FANTOM5 Ensembl 1.8 +240.2 240205 2 IKZF1 HDAC1 SOX6 CTBP1 ZFHX2 NR2F1 TAL1 ZNF513 EGR2 TEAD4 ENSG00000272462 H1-2 H4C3 H1-6 H2AC1 H2BC1 H4C7 piR-57461-202 ENSG00000272558 ENSG00000272810
GH06J026239 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 0.7 +4.8 4821 5.3 CEBPG CREB1 POLR2A BACH1 SMAD5 IKZF2 SP1 TRIM22 GTF2F1 YY1 H4C6 ABT1 HMGN4 H2AC10P BTN2A1 ZNF322 H4C7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H4C7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H4C7

Genomic Locations for H4C7 Gene

Genomic Locations for H4C7 Gene
chr6:26,246,611-26,246,996
(GRCh38/hg38)
Size:
386 bases
Orientation:
Minus strand
chr6:26,246,839-26,247,259
(GRCh37/hg19)
Size:
421 bases
Orientation:
Minus strand

Genomic View for H4C7 Gene

Genes around H4C7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H4C7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H4C7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H4C7 Gene

Proteins for H4C7 Gene

  • Protein details for H4C7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99525-H4G_HUMAN
    Recommended name:
    Histone H4-like protein type G
    Protein Accession:
    Q99525

    Protein attributes for H4C7 Gene

    Size:
    98 amino acids
    Molecular mass:
    11009 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

neXtProt entry for H4C7 Gene

Post-translational modifications for H4C7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H4C7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H4C7 Gene

Domains & Families for H4C7 Gene

Gene Families for H4C7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H4C7 Gene

InterPro:
Blocks:
  • Histone H4
ProtoNet:

Suggested Antigen Peptide Sequences for H4C7 Gene

GenScript: Design optimal peptide antigens:
  • Histone H4-like protein type G (H4G_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99525

UniProtKB/Swiss-Prot:

H4G_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with H4C7: view

Function for H4C7 Gene

Molecular function for H4C7 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Phenotypes From GWAS Catalog for H4C7 Gene

Gene Ontology (GO) - Molecular Function for H4C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H4C7: view
genes like me logo Genes that share phenotypes with H4C7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H4C7 Gene

Localization for H4C7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H4C7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H4C7 gene
Compartment Confidence
nucleus 4
extracellular 1
mitochondrion 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for H4C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA,HDA 21630459
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H4C7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H4C7 Gene

Pathways & Interactions for H4C7 Gene

genes like me logo Genes that share pathways with H4C7: view

Pathways by source for H4C7 Gene

1 BioSystems pathway for H4C7 Gene
2 Qiagen pathways for H4C7 Gene
  • Crosstalk Between CARM1 and ESRs
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for H4C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with H4C7: view

No data available for SIGNOR curated interactions for H4C7 Gene

Drugs & Compounds for H4C7 Gene

No Compound Related Data Available

Transcripts for H4C7 Gene

mRNA/cDNA for H4C7 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C7

Alternative Splicing Database (ASD) splice patterns (SP) for H4C7 Gene

No ASD Table

Relevant External Links for H4C7 Gene

GeneLoc Exon Structure for
H4C7

Expression for H4C7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H4C7

SOURCE GeneReport for Unigene cluster for H4C7 Gene:

Hs.553507
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4C7 Gene

Orthologs for H4C7 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for H4C7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC472229 30
  • 97.28 (n)
Species where no ortholog for H4C7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for H4C7 Gene

ENSEMBL:
Gene Tree for H4C7 (if available)
TreeFam:
Gene Tree for H4C7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H4C7: view image

Paralogs for H4C7 Gene

Paralogs for H4C7 Gene

genes like me logo Genes that share paralogs with H4C7: view

Variants for H4C7 Gene

Additional dbSNP identifiers (rs#s) for H4C7 Gene

Structural Variations from Database of Genomic Variants (DGV) for H4C7 Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
nsv1023453 CNV gain 25217958
nsv428137 CNV loss 18775914
nsv601173 CNV loss 21841781

Variation tolerance for H4C7 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H4C7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H4C7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H4C7 Gene

Disorders for H4C7 Gene

No disorders were found for H4C7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H4C7 Gene

Publications for H4C7 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A novel histone H4 variant H4G regulates rDNA transcription in breast cancer. (PMID: 31219579) Long M … Ishibashi T (Nucleic acids research 2019) 3
  5. Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer. (PMID: 28927264) Lee N … Choi KY (Molecules and cells 2017) 3

Products for H4C7 Gene

Sources for H4C7 Gene