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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H4C5 Gene
Aliases for H4C5 Gene
- H4 Clustered Histone 5 2 3 5
- H4/J 2 3 4
- Histone Cluster 1 H4 Family Member E 2 3
- H4 Histone Family, Member J 2 3
- Histone Cluster 1, H4e 2 3
- Histone 1, H4e 2 3
- Histone H4 3 4
- HIST1H4E 3 4
- H4FJ 3 4
- HIST1H4A 4
- HIST1H4B 4
- HIST1H4C 4
- HIST1H4D 4
- HIST1H4F 4
- HIST1H4H 4
- HIST1H4I 4
- HIST1H4J 4
- HIST1H4K 4
- HIST1H4L 4
- HIST2H4A 4
- HIST2H4B 4
- HIST2H4 4
- HIST4H4 4
- H4-16 3
- H4C11 3
- H4C12 3
- H4C13 3
- H4C14 3
- H4C15 3
- H4C1 3
- H4C2 3
External Ids for H4C5 Gene
- HGNC: 4790
- Entrez Gene: 8367
- Ensembl: ENSG00000276966
- OMIM: 602830
- UniProtKB: P62805
Previous HGNC Symbols for H4C5 Gene
- H4FJ
- HIST1H4E
Previous GeneCards Identifiers for H4C5 Gene
- GC06P027678
- GC06P028389
Summaries for H4C5 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for H4C5 Gene
H4C5 (H4 Clustered Histone 5) is a Protein Coding gene. Diseases associated with H4C5 include Hyperinsulinemic Hypoglycemia, Familial, 1 and Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H4C6.
UniProtKB/Swiss-Prot Summary for H4C5 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H4C5 Gene
- HGNC(4790)
- Entrez Gene(8367)
- Ensembl(ENSG00000276966)
- OMIM(602830)
- UniProtKB(P62805)
- Open Targets Platform(ENSG00000276966)
- Search for H4C5 at DataMed
- Search for H4C5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4C5 Gene
Genomics for H4C5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H4C5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J026193 | Promoter/Enhancer | 2.1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -3.8 | -3760 | 14.6 | ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629 | H2AC7 H2BC7 H3C4 ENSG00000282988 RPS10P1 ABT1 BTN2A2 BTN2A1 HMGN4 BTN2A3P | |
| GH06J026211 | Enhancer | 0.7 | Ensembl | 0.4 | +7.4 | 7449 | 1.2 | CREB1 PKNOX1 NR2C1 CTCF NCOR1 ARNT ZNF318 PBX2 POLR2A MNT | HSALNG0048742 LARP1P1 H2BC5 H1-4 H4C8 H2AC10P H2BC8 piR-54826 H4C5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H4C5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H4C5
Genomic Locations for H4C5 Gene
Genomic Locations for H4C5 Gene
- chr6:26,204,552-26,206,038
- (GRCh38/hg38)
- Size:
- 1,487 bases
- Orientation:
- Plus strand
- chr6:26,204,858-26,206,266
- (GRCh37/hg19)
- Size:
- 1,409 bases
- Orientation:
- Plus strand
Genomic View for H4C5 Gene
Genes around H4C5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H4C5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H4C5 Gene
Proteins for H4C5 Gene
-
Protein details for H4C5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for H4C5 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Evidence={ECO:0000305};
Post-translational modifications for H4C5 Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882). Monomethylation is performed by SET8 (PubMed:15964846). Dimethylation and trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity).
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Sumoylated, which is associated with transcriptional repression.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Butyrylation of histones marks active promoters and competes with histone acetylation.
- Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
-
Ubiquitination at Lys32, Lys60, Lys78, and Lys80
- NX_P62805 (NX_P62805-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H4C5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for H4C5
- Invitrogen Antibodies for H4C5 (AFLGC-H4C5)
Protein Products
-
OriGene Purified Proteins for H4C5
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- Origene Custom Protein Services for H4C5
- Novus Biologicals lysates for H4C5
Assay Products
-
Signalway ELISA kits for H4C5
No data available for DME Specific Peptides for H4C5 Gene
Domains & Families for H4C5 Gene
Gene Families for H4C5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for H4C5 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
No data available for Suggested Antigen Peptide Sequences for H4C5 Gene
Function for H4C5 Gene
Molecular function for H4C5 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H4C5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H4C5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H4C5 - Select products 50% OFF >
- * H4C5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H4C5
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miRNA for H4C5 Gene
- miRTarBase miRNAs that target H4C5
-
- hsa-miR-34a-5p (MIRT025407)
- hsa-miR-598-3p (MIRT040492)
- hsa-miR-26a-5p (MIRT050053)
- hsa-miR-3122 (MIRT739983)
- hsa-miR-3913-5p (MIRT742865)
- hsa-miR-450a-1-3p (MIRT745570)
- hsa-miR-4663 (MIRT746713)
- hsa-miR-4708-5p (MIRT747369)
- hsa-miR-4728-3p (MIRT747784)
- hsa-miR-4747-5p (MIRT748241)
- hsa-miR-5196-5p (MIRT750025)
- hsa-miR-6513-5p (MIRT753250)
- hsa-miR-7160-5p (MIRT759318)
- hsa-miR-8077 (MIRT760139)
- hsa-miR-887-5p (MIRT760407)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H4C5
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Clone Products
- Applied Biological Materials (abm): Clones for H4C5 - Select products 50% OFF >
- * H4C5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H4C5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H4C5
Cell Line Products
-
Horizon Cell Lines for H4C5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H4C5 Gene
Localization for H4C5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H4C5 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H4C5 Gene
Pathways & Interactions for H4C5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for H4C5 Gene
2 BioSystems pathways for H4C5 Gene
66 Reactome pathways for H4C5 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for H4C5 Gene
4 GeneGo (Thomson Reuters) pathways for H4C5 Gene
- Development Notch Signaling Pathway
- Development NOTCH1-mediated pathway for NF-KB activity modulation
- Signal transduction Activin A signaling regulation
- Transcription Sin3 and NuRD in transcription regulation
2 Qiagen pathways for H4C5 Gene
- Crosstalk Between CARM1 and ESRs
- Nuclear Receptor Activation by Vitamin-A
1 GeneTex pathway for H4C5 Gene
Interacting Proteins for H4C5 Gene
Selected Interacting proteins:
P62805-H4_HUMAN
ENSP00000484789
for H4C5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H4C5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IBA,IDA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for H4C5 Gene
Transcripts for H4C5 Gene
mRNA/cDNA for H4C5 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000615164 1487 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H4C5 - Select products 50% OFF >
- * H4C5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H4C5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H4C5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H4C5
- Browse OriGene Inhibitory RNA Products For H4C5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C5
Clone Products
- Applied Biological Materials (abm): Clones for H4C5 - Select products 50% OFF >
- * H4C5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H4C5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H4C5
Relevant External Links for H4C5 Gene
- GeneLoc Exon Structure for
- H4C5
Expression for H4C5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H4C5
SOURCE GeneReport for Unigene cluster for H4C5 Gene:
Hs.662174Evidence on tissue expression from TISSUES for H4C5 Gene
- Blood(5)
- Liver(5)
- Nervous system(4.7)
- Eye(4.5)
- Heart(3.5)
- Intestine(3)
- Kidney(3)
- Lung(2.8)
- Skin(2.6)
- Bone marrow(2.5)
- Muscle(2.4)
- Pancreas(2.4)
- Spleen(2.4)
- Lymph node(2.2)
- Adrenal gland(2.2)
- Bone(2.1)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for H4C5
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4C5 Gene
Orthologs for H4C5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | LOC517138 30 |
|
||
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC472228 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101733182 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC564610 30 |
|
||
| wufe37d09 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012885 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | His4:CG33907 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | his-56 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07660 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0119900 30 |
|
- Species where no ortholog for H4C5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for H4C5 Gene
- ENSEMBL:
- Gene Tree for H4C5 (if available)
- TreeFam:
- Gene Tree for H4C5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H4C5: view image
Paralogs for H4C5 Gene
Variants for H4C5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H4C5 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 809888 | Uncertain Significance: not provided | 26,204,780(+) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608397 | CNV | loss | 21293372 |
| esv3608398 | CNV | loss | 21293372 |
| esv3608399 | CNV | gain | 21293372 |
| nsv1021294 | CNV | loss | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.25;
5.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H4C5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H4C5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H4C5 Gene
Disorders for H4C5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperinsulinemic hypoglycemia, familial, 1 |
|
|
| hyperinsulinemic hypoglycemia, familial, 2 |
|
|
| hyperoxaluria, primary, type i |
|
|
| meier-gorlin syndrome 1 |
|
|
| carbohydrate metabolic disorder |
|
|
Search H4C5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.
Additional Disease Information for H4C5
No data available for Genatlas for H4C5 Gene
Publications for H4C5 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 3 4
- Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
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- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for H4C5 (AFLGC-H4C5)
- VectorBuilder Custom and pre-made DNA vectors for H4C5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H4C5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for H4C5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for H4C5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H4C5
- Horizon Cell Lines for H4C5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H4C5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H4C5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H4C5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C5
- Signalway ELISA kits for H4C5
Sources for H4C5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB