Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H4C5 Gene
Aliases for H4C5 Gene
External Ids for H4C5 Gene
- HGNC: 4790
- Entrez Gene: 8367
- Ensembl: ENSG00000276966
- OMIM: 602830
- UniProtKB: P62805
Previous HGNC Symbols for H4C5 Gene
- H4FJ
- HIST1H4E
Summaries for H4C5 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for H4C5 Gene
H4C5 (H4 Clustered Histone 5) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H4C11.
UniProtKB/Swiss-Prot Summary for H4C5 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4C5 Gene
Genomics for H4C5 Gene
GeneHancer (GH) Regulatory Elements for H4C5 Gene
Promoters and enhancers for H4C5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J026120 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 1.9 | -80.2 | -80208 | 8.5 | PPP1R10 GTF3C2 SIN3A ZBTB40 SP1 SREBF1 ZBTB6 LCORL FOXA1 RBPJ | H2AC6 H2BC4 piR-40096 piR-31751 piR-50446 ABT1 BTN2A3P HMGN4 BTN2A1 BTN2A2 | |
| GH06J026193 | Promoter/Enhancer | 2.1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.6 | -3.8 | -3760 | 14.6 | PPP1R10 E2F8 SIN3A ZBTB40 SP1 CTCF SREBF1 ZBTB6 FOXA1 MLX | ENSG00000217275 H2AC7 H2BC7 H3C4 ENSG00000282988 RPS10P1 ABT1 HMGN4 BTN2A3P BTN2A1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H4C5 on UCSC Golden Path with GeneCards custom track
Genomic Locations for H4C5 Gene
Genomic Locations for H4C5 Gene
- chr6:26,204,552-26,206,038
- (GRCh38/hg38)
- Size:
- 1,487 bases
- Orientation:
- Plus strand
- chr6:26,204,858-26,206,266
- (GRCh37/hg19)
- Size:
- 1,409 bases
- Orientation:
- Plus strand
Genomic View for H4C5 Gene
Genes around H4C5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H4C5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H4C5 Gene
Proteins for H4C5 Gene
-
Protein details for H4C5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62805-H4_HUMAN
- Recommended name:
- Histone H4
- Protein Accession:
- P62805
- A2VCL0
- P02304
- P02305
- Q6DRA9
- Q6FGB8
- Q6NWP7
Protein attributes for H4C5 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11367 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- SequenceCaution:
-
- Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
Post-translational modifications for H4C5 Gene
- Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
- Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
- Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
- Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
- Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
- Sumoylated, which is associated with transcriptional repression.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Butyrylation of histones marks active promoters and competes with histone acetylation.
-
Ubiquitination at Lys32, Lys60, Lys78, and Lys80
- NX_P62805 (NX_P62805-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H4C5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for H4C5
- Invitrogen Antibodies for H4C5 (AFLGC-HIST1H4E)
Protein Products
-
OriGene Purified Proteins for H4C5
- Search Origene for MassSpec and Protein Over-expression Lysates for H4C5
- Origene Custom Protein Services for H4C5
- Novus Biologicals lysates for H4C5
No data available for DME Specific Peptides for H4C5 Gene
Domains & Families for H4C5 Gene
Gene Families for H4C5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for H4C5 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62805- Family:
-
- Belongs to the histone H4 family.
No data available for Suggested Antigen Peptide Sequences for H4C5 Gene
Function for H4C5 Gene
Molecular function for H4C5 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H4C5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,TAS | 3035717 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9540062 |
| GO:0019904 | protein domain specific binding | IPI | 22368283 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H4C5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H4C5 - Select products 50% OFF >
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for H4C5 - Select products 50% OFF >
- * H4C5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * H4C5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for H4C5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H4C5
- genomics-online: cdna clones - Search results for available HIST1H4E gene related products
- orf clones - Search results for available HIST1H4E gene related products
Cell Line Products
-
Horizon Cell Lines for H4C5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H4C5 Gene
Localization for H4C5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H4C5 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
| GO:0000786 | nucleosome | TAS | 3035717 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H4C5 Gene
Pathways & Interactions for H4C5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for H4C5 Gene
2 BioSystems pathways for H4C5 Gene
66 Reactome pathways for H4C5 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for H4C5 Gene
4 GeneGo (Thomson Reuters) pathways for H4C5 Gene
2 Qiagen pathways for H4C5 Gene
- Crosstalk Between CARM1 and ESRs
- Nuclear Receptor Activation by Vitamin-A
1 GeneTex pathway for H4C5 Gene
Interacting Proteins for H4C5 Gene
GPS-Prot Interaction Network for H4C5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
| GO:0006334 | nucleosome assembly | IDA,IBA | 20498094 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
No data available for SIGNOR curated interactions for H4C5 Gene
Transcripts for H4C5 Gene
mRNA/cDNA for H4C5 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000615164 1487 bps (ENST00000615164.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H4C5 - Select products 50% OFF >
- * H4C5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * H4C5 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for H4C5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H4C5
- genomics-online: gRNA clones - Search results for available HIST1H4E gene related products
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for H4C5
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C5
- genomics-online: shRNA clones - Search results for available HIST1H4E gene related products
Clone Products
- Applied Biological Materials (abm): Clones for H4C5 - Select products 50% OFF >
- * H4C5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * H4C5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for H4C5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H4C5
- genomics-online: cdna clones - Search results for available HIST1H4E gene related products
- orf clones - Search results for available HIST1H4E gene related products
Expression for H4C5 Gene
NURSA nuclear receptor signaling pathways regulating expression of H4C5 Gene:
H4C5SOURCE GeneReport for Unigene cluster for H4C5 Gene:
Hs.662174Evidence on tissue expression from TISSUES for H4C5 Gene
- Nervous system(4.6)
- Liver(4.5)
- Eye(4.2)
- Intestine(2.8)
- Lung(2.7)
- Blood(2.4)
- Kidney(2.4)
- Heart(2.2)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for H4C5
- genomics-online: primer clones - Search results for available HIST1H4E gene related products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4C5 Gene
Orthologs for H4C5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC517138 32 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC472228 32 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101733182 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC564610 32 |
|
||
| wufe37d09 32 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012885 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33907 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-56 32 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07660 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0119900 32 |
|
- Species where no ortholog for H4C5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for H4C5 Gene
- ENSEMBL:
- Gene Tree for H4C5 (if available)
- TreeFam:
- Gene Tree for H4C5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H4C5: view image
Paralogs for H4C5 Gene
Variants for H4C5 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000103615 | -- | 26,205,130(+) | T/C | downstream_transcript_variant | |
| rs1000290963 | -- | 26,205,237(+) | G/C | downstream_transcript_variant | |
| rs1000842672 | -- | 26,204,511(+) | G/A | upstream_transcript_variant | |
| rs1000899401 | -- | 26,204,728(+) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1001577482 | -- | 26,205,177(+) | C/T | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608397 | CNV | loss | 21293372 |
| esv3608398 | CNV | loss | 21293372 |
| esv3608399 | CNV | gain | 21293372 |
| nsv1021294 | CNV | loss | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.25;
5.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H4C5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H4C5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H4C5 Gene
Disorders for H4C5 Gene
UniProtKB/Swiss-Prot
H4_HUMAN- Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.
Additional Disease Information for H4C5
No disorders were found for H4C5 Gene.
No data available for MalaCards and Genatlas for H4C5 Gene
Publications for H4C5 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 56
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4 56
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 3 4 56
- Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4 56
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
ExternalLinks
Products for H4C5 Gene
- Custom Antibody ServicesOriGene Antibodies for H4C5
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- Custom Assay Services
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- Browse Antibodies
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- Invitrogen Antibodies for H4C5 (AFLGC-HIST1H4E)
- Horizon Cell Lines for H4C5
- genomics-online: cdna clones - Search results for available HIST1H4E gene related products
- orf clones - Search results for available HIST1H4E gene related products
- genomics-online: gRNA clones - Search results for available HIST1H4E gene related products
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Sources for H4C5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
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