H4C2 Gene (Protein Coding)

H4 Clustered Histone 2

GC06M026026
GIFtS:
31
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...

Aliases for H4C2 Gene

Aliases for H4C2 Gene

  • H4 Clustered Histone 2 2 3 5
  • H4/I 2 3 4
  • Histone Cluster 1 H4 Family Member B 2 3
  • H4 Histone Family, Member I 2 3
  • Histone Cluster 1, H4b 2 3
  • Histone 1, H4b 2 3
  • Histone H4 3 4
  • HIST1H4B 3 4
  • H4FI 3 4
  • HIST1H4A 4
  • HIST1H4C 4
  • HIST1H4D 4
  • HIST1H4E 4
  • HIST1H4F 4
  • HIST1H4H 4
  • HIST1H4I 4
  • HIST1H4J 4
  • HIST1H4K 4
  • HIST1H4L 4
  • HIST2H4A 4
  • HIST2H4B 4
  • HIST2H4 4
  • HIST4H4 4
  • H4-16 3
  • H4C11 3
  • H4C12 3
  • H4C13 3
  • H4C14 3
  • H4C15 3
  • H4C1 3
  • H4C3 3
  • H4C4 3
  • H4C5 3
  • H4C6 3
  • H4C8 3
  • H4C9 3
  • H4C2 5
  • H4/A 4
  • H4FA 4
  • H4/G 4
  • H4FG 4
  • H4/B 4
  • H4FB 4
  • H4/J 4
  • H4FJ 4
  • H4/C 4
  • H4FC 4
  • H4/H 4
  • H4FH 4
  • H4/M 4
  • H4FM 4
  • H4/E 4
  • H4FE 4
  • H4/D 4
  • H4FD 4
  • H4/K 4
  • H4FK 4
  • H4/N 4
  • H4F2 4
  • H4FN 4
  • H4/O 4
  • H4FO 4

External Ids for H4C2 Gene

Previous HGNC Symbols for H4C2 Gene

  • H4FI
  • HIST1H4B

Summaries for H4C2 Gene

Entrez Gene Summary for H4C2 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for H4C2 Gene

H4C2 (H4 Clustered Histone 2) is a Protein Coding gene. Diseases associated with H4C2 include Hyperinsulinemic Hypoglycemia, Familial, 2 and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H4C5.

UniProtKB/Swiss-Prot Summary for H4C2 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for H4C2 Gene

Additional gene information for H4C2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4C2 Gene

Genomics for H4C2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for H4C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J026015 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.8 1843 20.5 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 H4C2 ABT1 BTN2A2 BTN2A1 HMGN4 BTN2A3P ZNF322 ENSG00000272462 GUSBP2 BTN3A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H4C2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H4C2

Genomic Locations for H4C2 Gene

Genomic Locations for H4C2 Gene
chr6:26,026,815-26,027,283
(GRCh38/hg38)
Size:
469 bases
Orientation:
Minus strand
chr6:26,027,124-26,027,480
(GRCh37/hg19)
Size:
357 bases
Orientation:
Minus strand

Genomic View for H4C2 Gene

Genes around H4C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H4C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H4C2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for H4C2 Gene

Proteins for H4C2 Gene

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  • Protein details for H4C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for H4C2 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for H4C2 Gene

neXtProt entry for H4C2 Gene

Post-translational modifications for H4C2 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882). Monomethylation is performed by SET8 (PubMed:15964846). Dimethylation and trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity).
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for H4C2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H4C2 Gene

Domains & Families for H4C2 Gene

Gene Families for H4C2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for H4C2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with H4C2: view

No data available for Suggested Antigen Peptide Sequences for H4C2 Gene

Function for H4C2 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for H4C2 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for H4C2 Gene

Gene Ontology (GO) - Molecular Function for H4C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,TAS 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H4C2: view
genes like me logo Genes that share phenotypes with H4C2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H4C2 Gene

Localization for H4C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H4C2 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H4C2 gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for H4C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with H4C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H4C2 Gene

Pathways & Interactions for H4C2 Gene

PathCards logo

SuperPathways for H4C2 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
DNA methylation
.88
RNA Polymerase I Promoter Opening
.88
B-WICH complex positively regulates rRNA expression
.86
Positive epigenetic regulation of rRNA expression
.86
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
.86
SIRT1 negatively regulates rRNA Expression
.84
NoRC negatively regulates rRNA expression
.83
RNA Polymerase I Chain Elongation
.83
PRC2 methylates histones and DNA
.83
RNA Polymerase I Transcription
.81
Negative epigenetic regulation of rRNA expression
.81
RNA Polymerase I Promoter Clearance
.81
Condensation of Prophase Chromosomes
.78
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
.76
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
.75
Epigenetic regulation of gene expression
.73
RHO GTPases activate PKNs
.72
Formation of the beta-catenin-TCF transactivating complex
.64
HDACs deacetylate histones
.60
Amyloid fiber formation
.55
Activation of anterior HOX genes in hindbrain development during early embryogenesis
.50
Activation of HOX genes during differentiation
.50
Systemic lupus erythematosus
.43
RMTs methylate histone arginines
.39
Alcoholism
.35
HDMs demethylate histones
.32
2 DNA Double-Strand Break Repair
DNA Double-Strand Break Repair
.83
Homology Directed Repair
.83
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
.79
Processing of DNA double-strand break ends
.74
G2/M DNA damage checkpoint
.74
DNA Repair
.53
3 Cellular Senescence (REACTOME)
Cellular Senescence
.64
Oxidative Stress Induced Senescence
.64
Senescence-Associated Secretory Phenotype (SASP)
.56
Cellular responses to stress
.44
4 Chromosome Maintenance
Chromosome Maintenance
.75
Telomere Maintenance
.75
Deposition of new CENPA-containing nucleosomes at the centromere
.66
Nucleosome assembly
.66
5 Cell Cycle, Mitotic
Cell Cycle
.83
Cell Cycle, Mitotic
.83
M Phase
.60
genes like me logo Genes that share pathways with H4C2: view

Pathways by source for H4C2 Gene

4 GeneGo (Thomson Reuters) pathways for H4C2 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • Signal transduction Activin A signaling regulation
  • Transcription Sin3 and NuRD in transcription regulation
2 Qiagen pathways for H4C2 Gene
  • Crosstalk Between CARM1 and ESRs
  • Nuclear Receptor Activation by Vitamin-A
1 GeneTex pathway for H4C2 Gene

Gene Ontology (GO) - Biological Process for H4C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IBA,IDA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with H4C2: view

No data available for SIGNOR curated interactions for H4C2 Gene

Drugs & Compounds for H4C2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for H4C2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for H4C2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C2

Alternative Splicing Database (ASD) splice patterns (SP) for H4C2 Gene

No ASD Table

Relevant External Links for H4C2 Gene

GeneLoc Exon Structure for
H4C2

Expression for H4C2 Gene

Products:

  1. Primer

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H4C2

SOURCE GeneReport for Unigene cluster for H4C2 Gene:

Hs.143080

Evidence on tissue expression from TISSUES for H4C2 Gene

  • Nervous system(4.7)
  • Blood(4.6)
  • Liver(4.6)
  • Eye(4.5)
  • Intestine(3)
  • Kidney(2.8)
  • Lung(2.8)
  • Heart(2.8)
  • Skin(2.6)
  • Pancreas(2.4)
  • Muscle(2.4)
  • Stomach(2.3)
  • Adrenal gland(2.2)
  • Bone(2.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4C2 Gene

Orthologs for H4C2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for H4C2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC462507 30
  • 83.17 (n)
Rat
(Rattus norvegicus)
 Mammalia Hist2h4 30
  • 82.85 (n)
Mouse
(Mus musculus)
 Mammalia Hist4h4 30
  • 81.23 (n)
H4f16 17
Cow
(Bos Taurus)
 Mammalia LOC529647 30
  • 79.94 (n)
Chicken
(Gallus gallus)
 Aves HIST1H46L3 30
  • 82.2 (n)
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100496758 30
  • 80.91 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC100332668 30
  • 80.91 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta His4:CG33871 30
  • 79.29 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HHF1 33
HHF2 33
Species where no ortholog for H4C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for H4C2 Gene

ENSEMBL:
Gene Tree for H4C2 (if available)
TreeFam:
Gene Tree for H4C2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H4C2: view image

Paralogs for H4C2 Gene

Paralogs for H4C2 Gene

genes like me logo Genes that share paralogs with H4C2: view

Variants for H4C2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H4C2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
708918 Benign: not provided 26,026,986(-) G/A SYNONYMOUS_VARIANT
713788 Benign: not provided 26,027,058(-) G/A SYNONYMOUS_VARIANT
722838 Benign: not provided 26,027,247(-) A/T SYNONYMOUS_VARIANT
755407 Likely Benign: not provided 26,027,154(-) C/T SYNONYMOUS_VARIANT
775231 Benign: not provided 26,026,974(-) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for H4C2 Gene

Structural Variations from Database of Genomic Variants (DGV) for H4C2 Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
esv3608392 CNV gain 21293372
nsv1023453 CNV gain 25217958
nsv1026692 CNV loss 25217958
nsv428137 CNV loss 18775914
nsv509122 CNV insertion 20534489

Variation tolerance for H4C2 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H4C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H4C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H4C2 Gene

Disorders for H4C2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for H4C2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hyperinsulinemic hypoglycemia, familial, 2
  • persistent hyperinsulinemic hypoglycemia of infancy; phhi
hyperinsulinemic hypoglycemia, familial, 1
  • hhf1
hyperoxaluria, primary, type i
  • hp1
meier-gorlin syndrome 1
  • eps
carbohydrate metabolic disorder
  • disorder of carbohydrate transport and metabolism
- elite association - COSMIC cancer census association via MalaCards
Search H4C2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for H4C2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with H4C2: view

No data available for Genatlas for H4C2 Gene

Publications for H4C2 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4
  3. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 3 4
  4. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W … Doenecke D (Genomics 1991) 3 4
  5. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4

ExternalLinks

View latest publications for H4C2 gene in Mastermind

Products for H4C2 Gene

  • Signalway ELISA kits for H4C2

Sources for H4C2 Gene