Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histon... See more...

Aliases for H4C15 Gene

Aliases for H4C15 Gene

  • H4 Clustered Histone 15 2 3
  • Histone Cluster 2 H4 Family Member B 2 3 5
  • HIST2H4B 3 4 5
  • Histone Cluster 2, H4b 2 3
  • Histone 2, H4b 2 3
  • Histone H4 3 4
  • H4/O 3 4
  • HIST1H4A 4
  • HIST1H4B 4
  • HIST1H4C 4
  • HIST1H4D 4
  • HIST1H4E 4
  • HIST1H4F 4
  • HIST1H4H 4
  • HIST1H4I 4
  • HIST1H4J 4
  • HIST1H4K 4
  • HIST1H4L 4
  • HIST2H4A 4
  • HIST2H4 4
  • HIST4H4 4
  • H4-16 3
  • H4C11 3
  • H4C12 3
  • H4C13 3
  • H4C14 3
  • H4C1 3
  • H4C2 3
  • H4C3 3
  • H4C4 3
  • H4C5 3
  • H4C6 3
  • H4C8 3
  • H4C9 3
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for H4C15 Gene

Previous HGNC Symbols for H4C15 Gene

  • HIST2H4B

Previous GeneCards Identifiers for H4C15 Gene

  • GC01M149877

Summaries for H4C15 Gene

Entrez Gene Summary for H4C15 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]

GeneCards Summary for H4C15 Gene

H4C15 (H4 Clustered Histone 15) is a Protein Coding gene. Diseases associated with H4C15 include Hyperinsulinemic Hypoglycemia, Familial, 1 and Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are Signaling by Wnt and Chromatin organization. An important paralog of this gene is H4C6.

UniProtKB/Swiss-Prot Summary for H4C15 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Additional gene information for H4C15 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4C15 Gene

Genomics for H4C15 Gene

GeneHancer (GH) Regulatory Elements for H4C15 Gene

Promoters and enhancers for H4C15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J149859 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 500.7 +0.4 409 5.6 ENSG00000264207 H4C15 H3C15
GH01J149846 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +10.3 10251 8.1 ZSCAN5C AFF1 ZBTB26 MYC CHD1 POLR2A MXI1 OSR2 NCOR1 SIN3A H2BC20P H2AC19 H3C15 lnc-HIST2H2AA3-1 lnc-HIST2H4B-1 piR-45268-002 PRPF3 SF3B4 UBE2D3P3 ENSG00000220323
GH01J149856 Promoter/Enhancer 0.5 Ensembl dbSUPER 0.7 +4.3 4309 1.8 H3C15 H4C15
GH01J149855 Promoter/Enhancer 0.5 Ensembl dbSUPER 0.4 +5.6 5609 0.4 H3C15 H4C15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H4C15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H4C15

Genomic Locations for H4C15 Gene

Genomic Locations for H4C15 Gene
chr1:149,854,045-149,861,210
(GRCh38/hg38)
Size:
7,166 bases
Orientation:
Minus strand
chr1:149,825,607-149,832,725
(GRCh37/hg19)
Size:
7,119 bases
Orientation:
Minus strand

Genomic View for H4C15 Gene

Genes around H4C15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H4C15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H4C15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H4C15 Gene

Proteins for H4C15 Gene

  • Protein details for H4C15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for H4C15 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for H4C15 Gene

neXtProt entry for H4C15 Gene

Post-translational modifications for H4C15 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882). Monomethylation is performed by SET8 (PubMed:15964846). Dimethylation and trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity).
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for H4C15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H4C15 Gene

Domains & Families for H4C15 Gene

Gene Families for H4C15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for H4C15 Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with H4C15: view

No data available for Suggested Antigen Peptide Sequences for H4C15 Gene

Function for H4C15 Gene

Molecular function for H4C15 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for H4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H4C15: view
genes like me logo Genes that share phenotypes with H4C15: view

Animal Model Products

CRISPR Products

miRNA for H4C15 Gene

miRTarBase miRNAs that target H4C15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C15

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H4C15 Gene

Localization for H4C15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H4C15 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H4C15 gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for H4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with H4C15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H4C15 Gene

Pathways & Interactions for H4C15 Gene

PathCards logo

SuperPathways for H4C15 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with H4C15: view

Pathways by source for H4C15 Gene

4 GeneGo (Thomson Reuters) pathways for H4C15 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • Signal transduction Activin A signaling regulation
  • Transcription Sin3 and NuRD in transcription regulation
1 GeneTex pathway for H4C15 Gene

Gene Ontology (GO) - Biological Process for H4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IBA,IDA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with H4C15: view

No data available for SIGNOR curated interactions for H4C15 Gene

Drugs & Compounds for H4C15 Gene

No Compound Related Data Available

Transcripts for H4C15 Gene

mRNA/cDNA for H4C15 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4C15

Alternative Splicing Database (ASD) splice patterns (SP) for H4C15 Gene

No ASD Table

Relevant External Links for H4C15 Gene

GeneLoc Exon Structure for
H4C15

Expression for H4C15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H4C15

SOURCE GeneReport for Unigene cluster for H4C15 Gene:

Hs.55468

Evidence on tissue expression from TISSUES for H4C15 Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Eye(4.2)
  • Blood(2.4)
  • Lung(2.1)
  • Intestine(2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4C15 Gene

Orthologs for H4C15 Gene

This gene was present in the common ancestor of animals.

Orthologs for H4C15 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h4a 30
  • 86.41 (n)
H4c1 17
chimpanzee
(Pan troglodytes)
Mammalia LOC737496 30
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912418 30
  • 83.5 (n)
cow
(Bos Taurus)
Mammalia LOC525863 30
  • 81.55 (n)
chicken
(Gallus gallus)
Aves HIST1H46L1 30
  • 85.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732103 30
  • 81.88 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:165555 30
  • 81.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33869 30
  • 76.7 (n)
Species where no ortholog for H4C15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for H4C15 Gene

ENSEMBL:
Gene Tree for H4C15 (if available)
TreeFam:
Gene Tree for H4C15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H4C15: view image

Paralogs for H4C15 Gene

Paralogs for H4C15 Gene

genes like me logo Genes that share paralogs with H4C15: view

Variants for H4C15 Gene

Additional dbSNP identifiers (rs#s) for H4C15 Gene

Structural Variations from Database of Genomic Variants (DGV) for H4C15 Gene

Variant ID Type Subtype PubMed ID
esv1007634 OTHER inversion 20482838
nsv46 OTHER inversion 15895083
nsv469694 CNV loss 16826518
nsv499132 OTHER inversion 21111241
nsv547843 CNV loss 21841781
nsv7182 OTHER inversion 18451855
nsv824564 CNV gain 20364138
nsv831503 CNV gain 17160897
nsv831525 CNV gain 17160897
nsv946379 CNV duplication 23825009
nsv946381 CNV duplication 23825009

Additional Variant Information for H4C15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H4C15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for H4C15 Gene

Disorders for H4C15 Gene

MalaCards: The human disease database

(6) MalaCards diseases for H4C15 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search H4C15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for H4C15

genes like me logo Genes that share disorders with H4C15: view

No data available for Genatlas for H4C15 Gene

Publications for H4C15 Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad CD … Stein GS (Gene 2004) 2 3 4 54
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 3 4 54
  3. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4 54
  4. Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. (PMID: 31542297) Bao X … Li XD (Molecular cell 2019) 4 54
  5. DNA damage detection in nucleosomes involves DNA register shifting. (PMID: 31142837) Matsumoto S … Thomä NH (Nature 2019) 3 54

Products for H4C15 Gene

Sources for H4C15 Gene