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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H4C13 (H4 Clustered Histone 13) is a Protein Coding gene. Diseases associated with H4C13 include B-Cell Non-Hodgkin Lymphoma and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H4C5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027862 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +4.9 | 4866 | 12.7 | SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 IKZF1 POLR2A | H1-5 MN298282 piR-37468 piR-57285-002 piR-45037 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZNF603P | |
GH06J027882 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | -9.1 | -9086 | 1.2 | ESR1 ZBTB33 L3MBTL2 | RF00017-5389 ZNF603P HCG13P H4C13 H3C12 | |
GH06J027877 | Enhancer | 0.3 | Ensembl | 0.7 | -3.6 | -3567 | 0.2 | ZNF24 ZBTB33 | HCG13P H4C13 lnc-HIST1H2BN-2 RF00017-5389 H3C12 | |
GH06J027876 | Enhancer | 0.3 | Ensembl | 0.7 | -3.2 | -3167 | 0.2 | PKNOX1 ZNF384 | H4C13 HCG13P lnc-HIST1H2BN-2 RF00017-5389 H3C12 | |
GH06J027886 | Enhancer | 0.5 | Ensembl dbSUPER | 0.4 | -13.0 | -12967 | 1.8 | ZBTB33 MLLT1 | ZNF603P OR2B8P RF00017-5389 H3C12 piR-56252 H4C13 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,TAS | 3035717 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9540062 |
GO:0019904 | protein domain specific binding | IPI | 22368283 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0000786 | nucleosome | TAS | 3035717 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
GO:0006334 | nucleosome assembly | IBA,IDA | 20498094 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | LOC488260 30 |
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Mouse (Mus musculus) |
Mammalia | Hist1h4n 30 |
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H4c18 17 |
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Chimpanzee (Pan troglodytes) |
Mammalia | LOC735611 30 |
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Rat (Rattus norvegicus) |
Mammalia | LOC100912290 30 |
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Cow (Bos Taurus) |
Mammalia | LOC530773 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485962 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC101882398 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | His4r 30 |
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Disorder | Aliases | PubMed IDs |
---|---|---|
b-cell non-hodgkin lymphoma |
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hyperinsulinemic hypoglycemia, familial, 1 |
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hyperinsulinemic hypoglycemia, familial, 2 |
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meier-gorlin syndrome 1 |
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hyperinsulinemic hypoglycemia, familial, 3 |
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