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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H4C12 (H4 Clustered Histone 12) is a Protein Coding gene. Diseases associated with H4C12 include B-Cell Non-Hodgkin Lymphoma and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H4C5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027828 | Promoter/Enhancer | 2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +0.8 | 764 | 4 | SP1 HNRNPL LEF1 POLR2A BACH1 LARP7 DDX20 MTA2 PHF21A RELA | H4C12 piR-36107-002 ZKSCAN8 ZKSCAN3 ZSCAN12 ZSCAN9 GUSBP2 ZKSCAN4 ZSCAN23 ZNF603P | |
GH06J027834 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | -5.9 | -5881 | 6.7 | ZNF221 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 | H2BC15 H2AC15 ZSCAN12 ZKSCAN8 ZKSCAN3 ZSCAN9 ZSCAN26 ZKSCAN4 PGBD1 GUSBP2 | |
GH06J027821 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.4 | +7.0 | 6963 | 6 | SP1 CREB1 HNRNPL ZNF629 PRDM10 REST LEF1 IKZF1 POLR2A BACH1 | H4C11 lnc-HIST1H4J-1 piR-36107-001 piR-31432-570 piR-40154-159 piR-49732-487 piR-53431-582 piR-54764-539 H2BC15 ZKSCAN4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,TAS | 3035717 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9540062 |
GO:0019904 | protein domain specific binding | IPI | 22368283 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0000786 | nucleosome | TAS | 3035717 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006303 | double-strand break repair via nonhomologous end joining | TAS | -- |
GO:0006334 | nucleosome assembly | IBA,IDA | 20498094 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Hist1h4j 30 |
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H4c11 17 |
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Rat (Rattus norvegicus) |
Mammalia | LOC102551184 30 |
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Cow (Bos Taurus) |
Mammalia | LOC518961 30 |
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Chimpanzee (Pan troglodytes) |
Mammalia | LOC462494 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492878 30 |
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Str.1273 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.17431 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-113a14.21 30 |
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African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012558 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | His4:CG33895 30 |
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Worm (Caenorhabditis elegans) |
Secernentea | his-18 30 |
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Barley (Hordeum vulgare) |
Liliopsida | Hv.12211 30 |
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||
Rice (Oryza sativa) |
Liliopsida | Os.12348 30 |
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Wheat (Triticum aestivum) |
Liliopsida | Ta.25145 30 |
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Corn (Zea mays) |
Liliopsida | Zm.15826 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3608441 | CNV | gain | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
b-cell non-hodgkin lymphoma |
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hyperinsulinemic hypoglycemia, familial, 1 |
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hyperinsulinemic hypoglycemia, familial, 2 |
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hyperinsulinemic hypoglycemia, familial, 3 |
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meier-gorlin syndrome 1 |
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