Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for H4-16 Gene

Aliases for H4-16 Gene

  • H4 Histone 16 2 3
  • Histone Cluster 4 H4 2 3 5
  • HIST4H4 3 4 5
  • Histone 4, H4 2 3
  • Histone H4 3 4
  • Histone Cluster 4, H4 2
  • HIST1H4A 4
  • HIST1H4B 4
  • HIST1H4C 4
  • HIST1H4D 4
  • HIST1H4E 4
  • HIST1H4F 4
  • HIST1H4H 4
  • HIST1H4I 4
  • HIST1H4J 4
  • HIST1H4K 4
  • HIST1H4L 4
  • HIST2H4A 4
  • HIST2H4B 4
  • HIST2H4 4
  • H4C11 3
  • H4C12 3
  • H4C13 3
  • H4C14 3
  • H4C15 3
  • H4/P 3
  • H4C1 3
  • H4C2 3
  • H4C3 3
  • H4C4 3
  • H4C5 3
  • H4C6 3
  • H4C8 3
  • H4C9 3
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for H4-16 Gene

Previous HGNC Symbols for H4-16 Gene

  • HIST4H4

Summaries for H4-16 Gene

Entrez Gene Summary for H4-16 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for H4-16 Gene

H4-16 (H4 Histone 16) is a Protein Coding gene. Diseases associated with H4-16 include B-Cell Non-Hodgkin Lymphoma and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Signaling by Wnt and Chromatin organization. An important paralog of this gene is H4C15.

UniProtKB/Swiss-Prot Summary for H4-16 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for H4-16 Gene

Additional gene information for H4-16 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4-16 Gene

Genomics for H4-16 Gene

GeneHancer (GH) Regulatory Elements for H4-16 Gene

Promoters and enhancers for H4-16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J014767 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.5 -1537 9.9 RXRA ZBTB40 ZNF217 CTCF ZSCAN5C TCF12 SIN3A POLR2G SP1 JUND H2AJ H4-16 lnc-HIST4H4-4 C12orf60 ENSG00000261324 ATF7IP ERP27 LOC105369669 lnc-HIST4H4-5 piR-43887
GH12J014945 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -184.2 -184183 19.1 ZBTB40 EP300 TCF12 SIN3A SP1 GTF2E2 JUND FOS ZBTB11 RFX1 ARHGDIB ERP27 PDE6H WBP11 ART4 H2AJ H4-16 SMCO3 C12orf60 ENSG00000256339
GH12J014883 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 -113.8 -113840 3.2 ZNF217 REST CTBP1 BCL11A CBFB MBD2 NBN GATA3 JUND EBF1 MGP lnc-ERP27-1 ENSG00000256339 ERP27 PDE6H ART4 SMCO3 ARHGDIB H2AJ H4-16
GH12J014937 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 10.3 -167.9 -167939 3.9 EP300 CTCF SMC3 BCL6 RAD21 NFATC1 SPI1 POLR2A ZNF143 ERP27 ARHGDIB PDE6H H4-16 ENSG00000256339 MGP C12orf60
GH12J014553 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 10 +216.6 216578 1.9 CTCF NFIC POLR2A SPI1 RAD21 RN7SKP134 RF00100-029 lnc-GUCY2C-1 H4-16 GUCY2C ERP27 PLBD1 PLBD1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H4-16 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H4-16

Genomic Locations for H4-16 Gene

Genomic Locations for H4-16 Gene
chr12:14,767,999-14,771,131
(GRCh38/hg38)
Size:
3,133 bases
Orientation:
Minus strand
chr12:14,920,933-14,924,065
(GRCh37/hg19)
Size:
3,133 bases
Orientation:
Minus strand

Genomic View for H4-16 Gene

Genes around H4-16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H4-16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H4-16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H4-16 Gene

Proteins for H4-16 Gene

  • Protein details for H4-16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for H4-16 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for H4-16 Gene

neXtProt entry for H4-16 Gene

Post-translational modifications for H4-16 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882). Monomethylation is performed by SET8 (PubMed:15964846). Dimethylation and trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity).
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for H4-16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for H4-16 Gene

Domains & Families for H4-16 Gene

Gene Families for H4-16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for H4-16 Gene

Suggested Antigen Peptide Sequences for H4-16 Gene

GenScript: Design optimal peptide antigens:
  • Histone H4 (H4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with H4-16: view

Function for H4-16 Gene

Molecular function for H4-16 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for H4-16 Gene

Gene Ontology (GO) - Molecular Function for H4-16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,TAS 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H4-16: view
genes like me logo Genes that share phenotypes with H4-16: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for H4-16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H4-16 Gene

Localization for H4-16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H4-16 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H4-16 gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for H4-16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with H4-16: view

Pathways & Interactions for H4-16 Gene

PathCards logo

SuperPathways for H4-16 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with H4-16: view

Pathways by source for H4-16 Gene

4 GeneGo (Thomson Reuters) pathways for H4-16 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • Signal transduction Activin A signaling regulation
  • Transcription Sin3 and NuRD in transcription regulation
1 R&D Systems pathway for H4-16 Gene
1 GeneTex pathway for H4-16 Gene

Gene Ontology (GO) - Biological Process for H4-16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with H4-16: view

No data available for SIGNOR curated interactions for H4-16 Gene

Drugs & Compounds for H4-16 Gene

(29) Drugs for H4-16 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(20) Additional Compounds for H4-16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with H4-16: view

Transcripts for H4-16 Gene

mRNA/cDNA for H4-16 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for H4-16

Alternative Splicing Database (ASD) splice patterns (SP) for H4-16 Gene

No ASD Table

Relevant External Links for H4-16 Gene

GeneLoc Exon Structure for
H4-16

Expression for H4-16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H4-16

SOURCE GeneReport for Unigene cluster for H4-16 Gene:

Hs.745457

Evidence on tissue expression from TISSUES for H4-16 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Eye(4.2)
  • Blood(2.4)
  • Kidney(2.3)
  • Lung(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with H4-16: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4-16 Gene

Orthologs for H4-16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for H4-16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST4H4 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIST4H4 31
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST4H4 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIST4H4 31
  • 100 (a)
OneToOne
LOC619094 30
  • 81.23 (n)
rat
(Rattus norvegicus)
Mammalia LOC680097 30
  • 84.14 (n)
mouse
(Mus musculus)
Mammalia Hist1h4i 30
  • 83.5 (n)
H4c9 17
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734426 30
  • 81.23 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.17 31
  • 100 (a)
ManyToMany
LOC562770 30
  • 80.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012574 30
  • 80.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33903 30
  • 79.61 (n)
worm
(Caenorhabditis elegans)
Secernentea his-5 30
  • 78.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF2 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59690 30
  • 77.35 (n)
rice
(Oryza sativa)
Liliopsida Os05g0462700 30
  • 81.55 (n)
Species where no ortholog for H4-16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for H4-16 Gene

ENSEMBL:
Gene Tree for H4-16 (if available)
TreeFam:
Gene Tree for H4-16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H4-16: view image

Paralogs for H4-16 Gene

Paralogs for H4-16 Gene

genes like me logo Genes that share paralogs with H4-16: view

Variants for H4-16 Gene

Additional dbSNP identifiers (rs#s) for H4-16 Gene

Variation tolerance for H4-16 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H4-16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H4-16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for H4-16 Gene

Disorders for H4-16 Gene

MalaCards: The human disease database

(14) MalaCards diseases for H4-16 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
b-cell non-hodgkin lymphoma
  • b-cell nhl
hyperinsulinemic hypoglycemia, familial, 1
  • hhf1
hyperinsulinemic hypoglycemia, familial, 2
  • persistent hyperinsulinemic hypoglycemia of infancy; phhi
colon adenoma
  • adenomatous polyp of colon
neuronal ceroid lipofuscinosis
  • batten disease
- elite association - COSMIC cancer census association via MalaCards
Search H4-16 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for H4-16

genes like me logo Genes that share disorders with H4-16: view

No data available for Genatlas for H4-16 Gene

Publications for H4-16 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 54
  2. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PMID: 21724829) Kang B … Zhang Z (Genes & development 2011) 3 4 54
  3. Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E … Ogryzko V (Proteomics 2009) 3 23 54
  4. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. (PMID: 19667075) Glover-Cutter K … Bentley DL (Molecular and cellular biology 2009) 3 23 54
  5. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q … Shipp MA (Molecular cell 2009) 3 4 54

Products for H4-16 Gene

Sources for H4-16 Gene