Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for H4-16 Gene

Aliases for H4-16 Gene

  • H4 Histone 16 2 3 5
  • Histone Cluster 4 H4 2 3
  • Histone 4, H4 2 3
  • Histone H4 3 4
  • HIST4H4 3 4
  • Histone Cluster 4, H4 2
  • MGC24116 2
  • HIST1H4A 4
  • HIST1H4B 4
  • HIST1H4C 4
  • HIST1H4D 4
  • HIST1H4E 4
  • HIST1H4F 4
  • HIST1H4H 4
  • HIST1H4I 4
  • HIST1H4J 4
  • HIST1H4K 4
  • HIST1H4L 4
  • HIST2H4A 4
  • HIST2H4B 4
  • HIST2H4 4
  • H4C11 3
  • H4C12 3
  • H4C13 3
  • H4C14 3
  • H4C15 3
  • H4-16 5
  • H4/P 3
  • H4C1 3
  • H4C2 3
  • H4C3 3
  • H4C4 3
  • H4C5 3
  • H4C6 3
  • H4C8 3
  • H4C9 3
  • H4/A 4
  • H4FA 4
  • H4/I 4
  • H4FI 4
  • H4/G 4
  • H4FG 4
  • H4/B 4
  • H4FB 4
  • H4/J 4
  • H4FJ 4
  • H4/C 4
  • H4FC 4
  • H4/H 4
  • H4FH 4
  • H4/M 4
  • H4FM 4
  • H4/E 4
  • H4FE 4
  • H4/D 4
  • H4FD 4
  • H4/K 4
  • H4FK 4
  • H4/N 4
  • H4F2 4
  • H4FN 4
  • H4/O 4
  • H4FO 4

External Ids for H4-16 Gene

Previous HGNC Symbols for H4-16 Gene

  • HIST4H4

Previous GeneCards Identifiers for H4-16 Gene

  • GC12M014768
  • GC12M014871

Summaries for H4-16 Gene

Entrez Gene Summary for H4-16 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

GeneCards Summary for H4-16 Gene

H4-16 (H4 Histone 16) is a Protein Coding gene. Diseases associated with H4-16 include Hyperinsulinemic Hypoglycemia, Familial, 1 and Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H4C2.

UniProtKB/Swiss-Prot Summary for H4-16 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for H4-16 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H4-16 Gene

Genomics for H4-16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for H4-16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H4-16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H4-16

Genomic Locations for H4-16 Gene

Latest Assembly
chr12:14,767,999-14,771,131
(GRCh38/hg38)
Size:
3,133 bases
Orientation:
Minus strand

Previous Assembly
chr12:14,923,654-14,924,065
(GRCh37/hg19 by Entrez Gene)
Size:
412 bases
Orientation:
Minus strand

chr12:14,920,933-14,924,065
(GRCh37/hg19 by Ensembl)
Size:
3,133 bases
Orientation:
Minus strand

Genomic View for H4-16 Gene

Genes around H4-16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H4-16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H4-16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H4-16 Gene

Proteins for H4-16 Gene

  • Protein details for H4-16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for H4-16 Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for H4-16 Gene

neXtProt entry for H4-16 Gene

Post-translational modifications for H4-16 Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882). Monomethylation is performed by KMT5A/SET8 (PubMed:15964846). Dimethylation and trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526).
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
  • Ubiquitination at Lys32, Lys60, Lys78, and Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for H4-16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for H4-16 Gene

Domains & Families for H4-16 Gene

Gene Families for H4-16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for H4-16 Gene

Suggested Antigen Peptide Sequences for H4-16 Gene

GenScript: Design optimal peptide antigens:
  • Histone H4 (H4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with H4-16: view

Function for H4-16 Gene

Molecular function for H4-16 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for H4-16 Gene

Gene Ontology (GO) - Molecular Function for H4-16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,TAS 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H4-16: view
genes like me logo Genes that share phenotypes with H4-16: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4-16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H4-16 Gene

Localization for H4-16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H4-16 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H4-16 gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for H4-16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000781 chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 14585971
genes like me logo Genes that share ontologies with H4-16: view

Pathways & Interactions for H4-16 Gene

PathCards logo

SuperPathways for H4-16 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with H4-16: view

Pathways by source for H4-16 Gene

4 GeneGo (Thomson Reuters) pathways for H4-16 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • Signal transduction Activin A signaling regulation
  • Transcription Sin3 and NuRD in transcription regulation
1 R&D Systems pathway for H4-16 Gene
1 GeneTex pathway for H4-16 Gene

Gene Ontology (GO) - Biological Process for H4-16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IBA,IDA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with H4-16: view

No data available for SIGNOR curated interactions for H4-16 Gene

Drugs & Compounds for H4-16 Gene

(28) Drugs for H4-16 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for H4-16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with H4-16: view

Transcripts for H4-16 Gene

mRNA/cDNA for H4-16 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H4-16

Alternative Splicing Database (ASD) splice patterns (SP) for H4-16 Gene

No ASD Table

Relevant External Links for H4-16 Gene

GeneLoc Exon Structure for
H4-16

Expression for H4-16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H4-16

SOURCE GeneReport for Unigene cluster for H4-16 Gene:

Hs.745457

Evidence on tissue expression from TISSUES for H4-16 Gene

  • Blood(4.6)
  • Liver(4.5)
  • Nervous system(4.5)
  • Eye(4.4)
  • Heart(2.6)
  • Intestine(2.6)
  • Lung(2.6)
  • Kidney(2.6)
  • Skin(2.3)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with H4-16: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H4-16 Gene

Orthologs for H4-16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for H4-16 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia HIST4H4 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia HIST4H4 30
  • 100 (a)
OneToOne
LOC619094 29
  • 81.23 (n)
Chimpanzee
(Pan troglodytes)
Mammalia HIST4H4 30
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HIST4H4 30
  • 100 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC680097 29
  • 84.14 (n)
Mouse
(Mus musculus)
Mammalia Hist1h4i 29
  • 83.5 (n)
H4c9 16
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101734426 29
  • 81.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.17 30
  • 100 (a)
ManyToMany
LOC562770 29
  • 80.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012574 29
  • 80.91 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta His4:CG33903 29
  • 79.61 (n)
Worm
(Caenorhabditis elegans)
Secernentea his-5 29
  • 78.32 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 32
HHF2 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G59690 29
  • 77.35 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0462700 29
  • 81.55 (n)
Species where no ortholog for H4-16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for H4-16 Gene

ENSEMBL:
Gene Tree for H4-16 (if available)
TreeFam:
Gene Tree for H4-16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H4-16: view image
Alliance of Genome Resources:
Additional Orthologs for H4-16

Paralogs for H4-16 Gene

Paralogs for H4-16 Gene

genes like me logo Genes that share paralogs with H4-16: view

Variants for H4-16 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for H4-16 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for H4-16 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H4-16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H4-16
Leiden Open Variation Database (LOVD)
H4-16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for H4-16 Gene

Disorders for H4-16 Gene

MalaCards: The human disease database

(21) MalaCards diseases for H4-16 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search H4-16 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for H4-16

genes like me logo Genes that share disorders with H4-16: view

No data available for Genatlas for H4-16 Gene

Publications for H4-16 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
  2. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (PMID: 21724829) Kang B … Zhang Z (Genes & development 2011) 3 4
  3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q … Shipp MA (Molecular cell 2009) 3 4
  4. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. (PMID: 19410544) Foltz DR … Cleveland DW (Cell 2009) 3 22
  5. Histone H4 is a major component of the antimicrobial action of human sebocytes. (PMID: 19536143) Lee DY … Gallo RL (The Journal of investigative dermatology 2009) 3 22

Products for H4-16 Gene

Sources for H4-16 Gene