Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H3C8 (H3 Clustered Histone 8) is a Protein Coding gene. Diseases associated with H3C8 include Childhood Brain Stem Glioma and Brain Stem Cancer. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J026268 | Promoter/Enhancer | 1.9 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.1 | -112 | 6.5 | SP1 CREB1 GATAD2A TEAD4 POLR2A BACH1 FOS JUND LARP7 STAT3 | H2AC10P H2BC10 H3C8 lnc-HIST1H2BI-1 ABT1 GUSBP2 ZNF322 ENSG00000272462 H4C8 BTN3A2 | |
GH06J026248 | Promoter/Enhancer | 2.2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | +16.5 | 16503 | 13 | CEBPG SP1 GATAD2A CTCF HNRNPL TEAD4 PRDM10 IKZF1 POLR2A BACH1 | LOC105374986 ABT1 ZNF322 GUSBP2 H2AC9P H4C8 LARP1P1 BTN2A2 H4C3 ENSG00000272462 | |
GH06J026266 | Enhancer | 0.2 | FANTOM5 | 0.4 | +5.2 | 5177 | 0.2 | H3C8 lnc-HIST1H2BH-1 H2BC9 | ||
GH06J026264 | Enhancer | 0.2 | Ensembl | 0.4 | +7.0 | 7014 | 0.8 | H4C8 BTN3A2 H3C8 lnc-HIST1H2BH-1 H2BC9 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10949293 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 21636898 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Chromatin organization | ||
5 | Mitotic Prophase |
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006325 | chromatin organization | TAS | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0007596 | blood coagulation | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | LOC611519 30 |
|
||
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471907 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC788250 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hist2h3c2 30 |
|
||
H3c15 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Hist2h3c2 30 |
|
||
Chicken (Gallus gallus) |
Aves | LOC769809 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100493100 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100334933 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33845 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
nsv601173 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
childhood brain stem glioma |
|
|
brain stem cancer |
|
|
brain stem glioma |
|
|
retinitis pigmentosa 18 |
|
|
infratentorial cancer |
|
|