Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histon... See more...
Aliases for H3C7 Gene
Aliases for H3C7 Gene
- H3 Clustered Histone 7 2 3 5
- Histone Cluster 1 H3 Family Member F 2 3
- H3 Histone Family, Member I 2 3
- Histone Cluster 1, H3f 2 3
- Histone 1, H3f 2 3
- Histone H3.1 3 4
- Histone H3/I 3 4
- HIST1H3F 3 4
- H3/I 2 3
- H3FI 3 4
- H3FC HIST1H3C 4
- Histone H3/A 4
- Histone H3/B 4
- Histone H3/C 4
- Histone H3/D 4
- Histone H3/F 4
- Histone H3/H 4
- Histone H3/J 4
- Histone H3/K 4
- Histone H3/L 4
- HIST1H3A 4
- HIST1H3B 4
- HIST1H3D 4
External Ids for H3C7 Gene
- HGNC: 4773
- Entrez Gene: 8968
- Ensembl: ENSG00000277775
- OMIM: 602816
- UniProtKB: P68431
Previous HGNC Symbols for H3C7 Gene
- H3FI
- HIST1H3F
Previous GeneCards Identifiers for H3C7 Gene
- GC06M026838
- GC06M027059
Summaries for H3C7 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H3C7 Gene
H3C7 (H3 Clustered Histone 7) is a Protein Coding gene. Diseases associated with H3C7 include Childhood Brain Stem Glioma and Adult Infiltrating Astrocytic Neoplasm. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C4.
UniProtKB/Swiss-Prot Summary for H3C7 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H3C7 Gene
- HGNC(4773)
- Entrez Gene(8968)
- Ensembl(ENSG00000277775)
- OMIM(602816)
- UniProtKB(P68431)
- Open Targets Platform(ENSG00000277775)
- Search for H3C7 at DataMed
- Search for H3C7 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H3C7 Gene
Genomics for H3C7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H3C7 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J026248 | Promoter/Enhancer | 2.2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -4.7 | -4677 | 13 | CEBPG SP1 GATAD2A CTCF HNRNPL TEAD4 PRDM10 IKZF1 POLR2A BACH1 | LOC105374986 ABT1 ZNF322 GUSBP2 H2AC9P H4C8 LARP1P1 BTN2A2 H4C3 ENSG00000272462 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H3C7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H3C7
Genomic Locations for H3C7 Gene
Genomic Locations for H3C7 Gene
- chr6:26,250,142-26,250,635
- (GRCh38/hg38)
- Size:
- 494 bases
- Orientation:
- Minus strand
- chr6:26,250,370-26,250,835
- (GRCh37/hg19)
- Size:
- 466 bases
- Orientation:
- Minus strand
Genomic View for H3C7 Gene
Genes around H3C7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H3C7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H3C7 Gene
Proteins for H3C7 Gene
-
Protein details for H3C7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68431-H31_HUMAN
- Recommended name:
- Histone H3.1
- Protein Accession:
- P68431
- A0PJT7
- A5PLR1
- P02295
- P02296
- P16106
- Q6ISV8
- Q6NWP8
- Q6NWP9
- Q6NXU4
- Q71DJ3
- Q93081
Protein attributes for H3C7 Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15404 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
Post-translational modifications for H3C7 Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
- Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
- Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes (PubMed:29211711). It gives a specific tag for epigenetic transcription activation (PubMed:29211711). Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair (PubMed:27436229).
- Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:30257210). Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac) (PubMed:30257210).
-
Ubiquitination at Lys116
- NX_P68431 (NX_P68431-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H3C7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for H3C7 (AFLGC-H3C7)
- antibodies-online: Show 4 available HTR12 Antibodies ranked by validation data
- Compare Top HTR12 Antibodies
-
Quality Products:
Protein Products
-
OriGene Purified Proteins for H3C7
- Search Origene for MassSpec and Protein Over-expression Lysates for H3C7
- Origene Custom Protein Services for H3C7
- antibodies-online: Show 2 available HTR12 Proteins ranked by validation data
- Compare Top HTR12 Proteins
-
Quality Products:
No data available for DME Specific Peptides for H3C7 Gene
Domains & Families for H3C7 Gene
Gene Families for H3C7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for H3C7 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P68431- Family:
-
- Belongs to the histone H3 family.
No data available for Suggested Antigen Peptide Sequences for H3C7 Gene
Function for H3C7 Gene
Molecular function for H3C7 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H3C7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10949293 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H3C7 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H3C7 - Select products 50% OFF >
- * H3C7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H3C7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3C7
miRNA for H3C7 Gene
- miRTarBase miRNAs that target H3C7
-
- hsa-miR-34a-5p (MIRT025559)
- hsa-miR-760 (MIRT392097)
- hsa-miR-6822-3p (MIRT392102)
- hsa-miR-5693 (MIRT511637)
- hsa-miR-659-3p (MIRT511638)
- hsa-miR-29b-2-5p (MIRT511639)
- hsa-miR-8057 (MIRT511640)
- hsa-miR-299-5p (MIRT511641)
- hsa-miR-9-5p (MIRT511642)
- hsa-miR-4766-5p (MIRT511643)
- hsa-miR-146a-3p (MIRT511644)
- hsa-miR-1276 (MIRT511645)
- hsa-miR-382-5p (MIRT523197)
- hsa-miR-495-5p (MIRT523198)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3C7
- Browse OriGene Inhibitory RNA Products For H3C7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3C7
Clone Products
- Applied Biological Materials (abm): Clones for H3C7 - Select products 50% OFF >
- * H3C7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H3C7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3C7
Cell Line Products
-
Horizon Cell Lines for H3C7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H3C7 Gene
Localization for H3C7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H3C7 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000786 | nucleosome | IDA | 21636898 |
| GO:0000788 | nuclear nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IBA,IDA | 21636898 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H3C7 Gene
Pathways & Interactions for H3C7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Chromatin organization | ||
| 5 | Mitotic Prophase |
.57
|
|
Pathways by source for H3C7 Gene
1 BioSystems pathway for H3C7 Gene
54 Reactome pathways for H3C7 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
4 KEGG pathways for H3C7 Gene
8 Qiagen pathways for H3C7 Gene
- Crosstalk Between CARM1 and ESRs
- ERK Signaling
- Interferon Pathway
- MAPK Family Pathway
- Nuclear Receptor Activation by Vitamin-A
1 GeneTex pathway for H3C7 Gene
Interacting Proteins for H3C7 Gene
Selected Interacting proteins:
P68431-H31_HUMAN
ENSP00000484095
for H3C7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H3C7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0006334 | nucleosome assembly | IMP | 25615412 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0007596 | blood coagulation | TAS | -- |
No data available for SIGNOR curated interactions for H3C7 Gene
Transcripts for H3C7 Gene
mRNA/cDNA for H3C7 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000618052 494 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H3C7 - Select products 50% OFF >
- * H3C7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H3C7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3C7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3C7
- Browse OriGene Inhibitory RNA Products For H3C7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3C7
Clone Products
- Applied Biological Materials (abm): Clones for H3C7 - Select products 50% OFF >
- * H3C7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H3C7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3C7
Relevant External Links for H3C7 Gene
- GeneLoc Exon Structure for
- H3C7
Expression for H3C7 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H3C7
SOURCE GeneReport for Unigene cluster for H3C7 Gene:
Hs.247814Evidence on tissue expression from TISSUES for H3C7 Gene
- Nervous system(4.5)
- Blood(4.4)
- Spleen(4.2)
- Stomach(4.1)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for H3C7
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H3C7 Gene
Orthologs for H3C7 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Mouse (Mus musculus) |
Mammalia | Hist1h3i 30 |
|
||
| H3c11 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | LOC682330 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497984 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012559 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33818 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7493 30 |
|
- Species where no ortholog for H3C7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for H3C7 Gene
- ENSEMBL:
- Gene Tree for H3C7 (if available)
- TreeFam:
- Gene Tree for H3C7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H3C7: view image
Paralogs for H3C7 Gene
Variants for H3C7 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv601173 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.29;
6.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H3C7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H3C7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H3C7 Gene
Disorders for H3C7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| childhood brain stem glioma |
|
|
| adult infiltrating astrocytic neoplasm |
|
|
| brain stem cancer |
|
|
| brain stem glioma |
|
|
| tonsil squamous cell carcinoma |
|
|
Search H3C7 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
H31_HUMAN- Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269 PubMed:22286216}. Note=The gene represented in this entry is involved in disease pathogenesis. HIST1H3B mutations affecting residue Lys-28 involved in post-translational modifications of histone H3.1 are recurrent in malignant, aggressive gliomas including pediatric non-brain stem glioblastoma and diffuse intrinsic pontine glioma (DIPG) (PubMed:22286216). The mechanism through which mutations lead to tumorigenesis involves altered histone methylation, impaired regulation of Polycomb repressive complex 2 (PRC2) activity, and aberrant epigenetic regulation of gene expression (PubMed:23603901). {ECO:0000269 PubMed:22286216, ECO:0000269 PubMed:23603901}.
- Note=HIST1H3B or HIST1H3C mutations affecting residue Lys-37 of histone H3.1 are involved in the pathogenesis of pediatric undifferentiated soft tissue sarcomas. The mechanism through which mutations lead to tumorigenesis involves altered histones methylation with gain of global H3K27 methylation, altered Polycomb repressive complex 1 (PRC1) activity, aberrant epigenetic regulation of gene expression and impaired differentiation of mesenchimal progenitor cells. {ECO:0000269 PubMed:27174990}.
Additional Disease Information for H3C7
No data available for Genatlas for H3C7 Gene
Publications for H3C7 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4
- Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PMID: 16267050) Hake SB … Hunt DF (The Journal of biological chemistry 2006) 3 4
- Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PMID: 16246723) Macdonald N … Mahadevan LC (Molecular cell 2005) 3 4
- Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. (PMID: 11242053) Lachner M … Jenuwein T (Nature 2001) 3 4
ExternalLinks
Products for H3C7 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for H3C7
- Search Origene for MassSpec and Protein Over-expression Lysates for H3C7
- Origene Custom Protein Services for H3C7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3C7
- Browse OriGene Inhibitory RNA Products For H3C7
- OriGene qPCR primer pairs for H3C7
- OriGene CRISPR knockouts for H3C7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For H3C7
- Sino Biological Human cDNA Clone for H3C7
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for H3C7 (AFLGC-H3C7)
- VectorBuilder Custom and pre-made DNA vectors for H3C7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H3C7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for H3C7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for H3C7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H3C7
- antibodies-online: Show 4 available HTR12 Antibodies ranked by validation data
- Compare Top HTR12 Antibodies
- Quality Products:
- antibodies-online: Search results for available HTR12 related products ranked by validation data
- antibodies-online: Show 2 available HTR12 Proteins ranked by validation data
- Compare Top HTR12 Proteins
- Quality Products:
- Horizon Cell Lines for H3C7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3C7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3C7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H3C7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3C7
Sources for H3C7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB