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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H3C7 (H3 Clustered Histone 7) is a Protein Coding gene. Diseases associated with H3C7 include Childhood Brain Stem Glioma and Adult Infiltrating Astrocytic Neoplasm. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J026248 | Promoter/Enhancer | 2.2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -4.7 | -4677 | 13 | CEBPG SP1 GATAD2A CTCF HNRNPL TEAD4 PRDM10 IKZF1 POLR2A BACH1 | LOC105374986 ABT1 ZNF322 GUSBP2 H2AC9P H4C8 LARP1P1 BTN2A2 H4C3 ENSG00000272462 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10949293 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 21636898 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Chromatin organization | ||
5 | Mitotic Prophase |
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006325 | chromatin organization | TAS | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0007596 | blood coagulation | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Hist1h3i 30 |
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H3c11 17 |
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Rat (Rattus norvegicus) |
Mammalia | LOC682330 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497984 30 |
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African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012559 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33818 30 |
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Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7493 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
nsv601173 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
childhood brain stem glioma |
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adult infiltrating astrocytic neoplasm |
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brain stem cancer |
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brain stem glioma |
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tonsil squamous cell carcinoma |
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