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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H3C6 (H3 Clustered Histone 6) is a Protein Coding gene. Diseases associated with H3C6 include Childhood Brain Stem Glioma and Brain Stem Cancer. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10949293 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 21636898 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
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.35
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2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
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.60
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4 | Chromatin organization | ||
5 | Mitotic Prophase |
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006325 | chromatin organization | TAS | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0007596 | blood coagulation | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | LOC463171 30 |
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Cow (Bos Taurus) |
Mammalia | LOC523214 30 |
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Mouse (Mus musculus) |
Mammalia | Hist1h3h 30 |
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H3c10 17 |
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Rat (Rattus norvegicus) |
Mammalia | Hist1h2ail 30 |
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Dog (Canis familiaris) |
Mammalia | LOC488306 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732670 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | hist2h3c 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33836 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G75600 30 |
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Rice (Oryza sativa) |
Liliopsida | Os03g0390600 30 |
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Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
nsv1021294 | CNV | loss | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
childhood brain stem glioma |
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brain stem cancer |
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clear cell chondrosarcoma |
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brain stem glioma |
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infratentorial cancer |
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