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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H3C6 Gene
Aliases for H3C6 Gene
- H3 Clustered Histone 6 2 3 5
- Histone Cluster 1 H3 Family Member E 2 3
- H3 Histone Family, Member D 2 3
- Histone Cluster 1, H3e 2 3
- Histone 1, H3e 2 3
- Histone H3.1 3 4
- Histone H3/D 3 4
- HIST1H3E 3 4
- H3.1 2 3
- H3/D 2 3
- H3FD 3 4
- H3FC HIST1H3C 4
- Histone H3/A 4
- Histone H3/B 4
- Histone H3/C 4
- Histone H3/F 4
- Histone H3/H 4
- Histone H3/I 4
- Histone H3/J 4
- Histone H3/K 4
- Histone H3/L 4
- HIST1H3A 4
- HIST1H3B 4
External Ids for H3C6 Gene
- HGNC: 4769
- NCBI Entrez Gene: 8353
- Ensembl: ENSG00000274750
- OMIM®: 602813
- UniProtKB/Swiss-Prot: P68431
Previous HGNC Symbols for H3C6 Gene
- H3FD
- HIST1H3E
Previous GeneCards Identifiers for H3C6 Gene
- GC06P027677
- GC06P028387
- GC06P028904
- GC06P049186
Summaries for H3C6 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for H3C6 Gene
H3C6 (H3 Clustered Histone 6) is a Protein Coding gene. Diseases associated with H3C6 include Childhood Brain Stem Glioma and Brain Stem Cancer. Among its related pathways are Cellular Senescence (REACTOME) and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H3C2.
UniProtKB/Swiss-Prot Summary for H3C6 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H3C6 Gene
- HGNC (4769)
- NCBI Entrez Gene (8353)
- Ensembl (ENSG00000274750)
- OMIM® (602813)
- UniProtKB/Swiss-Prot (P68431)
- Open Targets Platform(ENSG00000274750)
- Alliance of Genome Resources
- Search for H3C6 at DataMed
- Search for H3C6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H3C6 Gene
Genomics for H3C6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H3C6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H3C6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H3C6
Genomic Locations for H3C6 Gene
Latest Assembly
- chr6:26,224,178-26,227,473
- (GRCh38/hg38)
- Size:
- 3,296 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:26,224,406-26,227,701
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,296 bases
- Orientation:
- Plus strand
Genomic View for H3C6 Gene
Genes around H3C6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H3C6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H3C6 Gene
Proteins for H3C6 Gene
-
Protein details for H3C6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68431-H31_HUMAN
- Recommended name:
- Histone H3.1
- Protein Accession:
- P68431
- A0PJT7
- A5PLR1
- P02295
- P02296
- P16106
- Q6ISV8
- Q6NWP8
- Q6NWP9
- Q6NXU4
- Q71DJ3
- Q93081
Protein attributes for H3C6 Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15404 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
Post-translational modifications for H3C6 Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
- Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
- Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
- Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes (PubMed:29211711). It gives a specific tag for epigenetic transcription activation (PubMed:29211711). Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair (PubMed:27436229).
- Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:30257210). Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac) (PubMed:30257210).
-
Glycosylation at Ser11
- NX_P68431 (NX_P68431-1)
-
Ubiquitination at Lys116
- NX_P68431 (NX_P68431-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- H31_HUMAN (2886)
Other Protein References for H3C6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for H3C6
- antibodies-online: Show 7 available HIST1H3E Antibodies ranked by validation data
- Compare Top HIST1H3E Antibodies
-
Quality Products:
Protein products for research
-
OriGene Purified Proteins for H3C6
- Search Origene for MassSpec and Protein Over-expression Lysates for H3C6
- Origene Custom Protein Services for H3C6
Assay products for research
No data available for DME Specific Peptides for H3C6 Gene
Domains & Families for H3C6 Gene
Gene Families for H3C6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for H3C6 Gene
- InterPro:
Graphical View of Domain Structure for InterPro Entry
P68431- Family:
-
- Belongs to the histone H3 family.
No data available for Suggested Antigen Peptide Sequences for H3C6 Gene
Function for H3C6 Gene
Molecular function for H3C6 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H3C6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10949293 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H3C6 Gene
- GenomeRNAi human phenotypes for H3C6:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H3C6 - Starting at $85 >
- * H3C6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H3C6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3C6
miRNA for H3C6 Gene
- miRTarBase miRNAs that target H3C6
-
- hsa-miR-34a-5p (MIRT025324)
- hsa-miR-1253 (MIRT360284)
- hsa-miR-4251 (MIRT360286)
- hsa-miR-5004-3p (MIRT360288)
- hsa-miR-5197-3p (MIRT360289)
- hsa-miR-7856-5p (MIRT523199)
- hsa-miR-4477b (MIRT523200)
- hsa-miR-8057 (MIRT523201)
- hsa-miR-6822-3p (MIRT523202)
- hsa-miR-1290 (MIRT523203)
- hsa-miR-876-5p (MIRT523204)
- hsa-miR-3167 (MIRT523205)
- hsa-miR-6770-5p (MIRT523206)
- hsa-miR-6761-5p (MIRT523207)
- hsa-miR-4329 (MIRT523208)
- hsa-miR-3921 (MIRT523209)
- hsa-miR-4653-5p (MIRT523210)
- hsa-miR-760 (MIRT523211)
- hsa-miR-372-5p (MIRT529015)
- hsa-miR-371a-5p (MIRT529016)
- hsa-miR-616-5p (MIRT529017)
- hsa-miR-373-5p (MIRT529018)
- hsa-miR-371b-5p (MIRT529019)
- hsa-miR-6827-3p (MIRT529020)
- hsa-miR-340-3p (MIRT529021)
- hsa-miR-4698 (MIRT529022)
- hsa-miR-8063 (MIRT529023)
- hsa-miR-5692a (MIRT544415)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3C6
- Browse OriGene Inhibitory RNA Products For H3C6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3C6
Clone products for research
- Applied Biological Materials (abm): Clones for H3C6 - Starting at $45 >
- * H3C6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H3C6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3C6
Cell Lines for research
-
Horizon Cell Lines for H3C6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H3C6 Gene
Localization for H3C6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H3C6 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 14718166 |
| GO:0000786 | nucleosome | IDA | 20498094 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA,IDA | 21636898 |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H3C6 Gene
Pathways & Interactions for H3C6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Chromatin organization | ||
| 5 | Mitotic Prophase |
.57
|
|
Pathways by source for H3C6 Gene
1 BioSystems pathway for H3C6 Gene
54 Reactome pathways for H3C6 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
5 KEGG pathways for H3C6 Gene
8 Qiagen pathways for H3C6 Gene
- Crosstalk Between CARM1 and ESRs
- ERK Signaling
- Interferon Pathway
- MAPK Family Pathway
- Nuclear Receptor Activation by Vitamin-A
1 GeneTex pathway for H3C6 Gene
Interacting Proteins for H3C6 Gene
Selected Interacting proteins:
P68431-H31_HUMAN
ENSP00000482271
for H3C6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H3C6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0006334 | nucleosome assembly | IMP | 25615412 |
| GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
| GO:0007596 | blood coagulation | TAS | -- |
No data available for SIGNOR curated interactions for H3C6 Gene
Transcripts for H3C6 Gene
mRNA/cDNA for H3C6 Gene
- 2 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000614911 462 nts (view in UCSC)
- ENST00000634733 2679 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H3C6 - Starting at $85 >
- * H3C6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H3C6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3C6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3C6
- Browse OriGene Inhibitory RNA Products For H3C6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3C6
Clone products for research
- Applied Biological Materials (abm): Clones for H3C6 - Starting at $45 >
- * H3C6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H3C6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3C6
Relevant External Links for H3C6 Gene
- GeneLoc Exon Structure for
- H3C6
Expression for H3C6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H3C6
SOURCE GeneReport for Unigene cluster for H3C6 Gene:
Hs.443021Evidence on tissue expression from TISSUES for H3C6 Gene
- Nervous system(4.5)
- Blood(4.4)
- Spleen(4.2)
- Stomach(4.1)
- Kidney(2)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for H3C6
-
OriGene qPCR primer pairs and template standards for H3C6
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H3C6 Gene
Orthologs for H3C6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC463171 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | LOC523214 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hist1h3h 29 |
|
||
| H3c10 16 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Hist1h2ail 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | LOC488306 29 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732670 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hist2h3c 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33836 29 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G75600 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0390600 29 |
|
- Species where no ortholog for H3C6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for H3C6 Gene
- ENSEMBL:
- Gene Tree for H3C6 (if available)
- TreeFam:
- Gene Tree for H3C6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H3C6: view image
- Alliance of Genome Resources:
- Additional Orthologs for H3C6
Paralogs for H3C6 Gene
Variants for H3C6 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1021294 | CNV | loss | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H3C6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H3C6 Gene
Disorders for H3C6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| childhood brain stem glioma |
|
|
| brain stem cancer |
|
|
| diffuse midline glioma, h3 k27m-mutant |
|
|
| clear cell chondrosarcoma |
|
|
| brain stem glioma |
|
|
Search H3C6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
H31_HUMAN- Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269 PubMed:22286216}. Note=The gene represented in this entry is involved in disease pathogenesis. HIST1H3B mutations affecting residue Lys-28 involved in post-translational modifications of histone H3.1 are recurrent in malignant, aggressive gliomas including pediatric non-brain stem glioblastoma and diffuse intrinsic pontine glioma (DIPG) (PubMed:22286216). The mechanism through which mutations lead to tumorigenesis involves altered histone methylation, impaired regulation of Polycomb repressive complex 2 (PRC2) activity, and aberrant epigenetic regulation of gene expression (PubMed:23603901). {ECO:0000269 PubMed:22286216, ECO:0000269 PubMed:23603901}.
- Note=HIST1H3B or HIST1H3C mutations affecting residue Lys-37 of histone H3.1 are involved in the pathogenesis of pediatric undifferentiated soft tissue sarcomas. The mechanism through which mutations lead to tumorigenesis involves altered histones methylation with gain of global H3K27 methylation, altered Polycomb repressive complex 1 (PRC1) activity, aberrant epigenetic regulation of gene expression and impaired differentiation of mesenchimal progenitor cells. {ECO:0000269 PubMed:27174990}.
Additional Disease Information for H3C6
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No data available for Genatlas for H3C6 Gene
Publications for H3C6 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W … Doenecke D (Genomics 1991) 2 3 4
- Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PMID: 16267050) Hake SB … Hunt DF (The Journal of biological chemistry 2006) 3 4
- Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PMID: 16246723) Macdonald N … Mahadevan LC (Molecular cell 2005) 3 4
- Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PMID: 14718166) Tagami H … Nakatani Y (Cell 2004) 3 22
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