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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H3C4 (H3 Clustered Histone 4) is a Protein Coding gene. Diseases associated with H3C4 include Childhood Brain Stem Glioma and Brain Stem Cancer. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10949293 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 21636898 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Chromatin organization | ||
5 | Mitotic Prophase |
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006325 | chromatin organization | TAS | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0007596 | blood coagulation | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Hist1h3i 31 |
|
ManyToMany | |
Hist1h3a 30 |
|
||||
H3c1 17 |
|
||||
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
ManyToMany | |
LOC462506 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
LOC525511 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
LOC100684574 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | LOC691496 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487139 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100329422 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33848 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CSE4 33 |
|
|
|
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10591 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15445 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv375n21 | CNV | loss | 19592680 |
dgv5926n100 | CNV | gain | 25217958 |
esv3608397 | CNV | loss | 21293372 |
esv3608398 | CNV | loss | 21293372 |
esv3608399 | CNV | gain | 21293372 |
nsv1021294 | CNV | loss | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
childhood brain stem glioma |
|
|
brain stem cancer |
|
|
glioblastoma multiforme |
|
|
brain stem glioma |
|
|
clear cell chondrosarcoma |
|
|