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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H3C12 (H3 Clustered Histone 12) is a Protein Coding gene. Diseases associated with H3C12 include Adult Infiltrating Astrocytic Neoplasm and Childhood Brain Stem Glioma. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10949293 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 21636898 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Chromatin organization | ||
5 | Mitotic Prophase |
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006325 | chromatin organization | TAS | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0007596 | blood coagulation | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H3J 31 |
|
OneToOne | |
LOC471875 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | LOC540148 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LOC488277 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hist1h3g 30 |
|
||
H3c8 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | LOC680498 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732029 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100004914 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33830 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | his-2 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CSE4 33 |
|
|
|
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G40030 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0130900 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
adult infiltrating astrocytic neoplasm |
|
|
childhood brain stem glioma |
|
|
brain stem cancer |
|
|
brain stem glioma |
|
|
tonsil squamous cell carcinoma |
|
|