Aliases for H3C12 Gene
External Ids for H3C12 Gene
Previous HGNC Symbols for H3C12 Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H3C12 Gene
H3C12 (H3 Clustered Histone 12) is a Protein Coding gene. Diseases associated with H3C12 include Corneal Dystrophy, Posterior Polymorphous, 1 and Brain Stem Glioma. Among its related pathways are Cellular Senescence (REACTOME) and Meiosis. An important paralog of this gene is H3C7.
UniProtKB/Swiss-Prot Summary for H3C12 Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.