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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H3C11 (H3 Clustered Histone 11) is a Protein Coding gene. Diseases associated with H3C11 include Adult Infiltrating Astrocytic Neoplasm and Childhood Brain Stem Glioma. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. An important paralog of this gene is H3C4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027862 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +3.7 | 3678 | 12.7 | SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 IKZF1 POLR2A | H1-5 MN298282 piR-37468 piR-57285-002 piR-45037 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZNF603P |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10949293 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 20498094 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,IDA | 21636898 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Chromatin organization | ||
5 | Mitotic Prophase |
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0006325 | chromatin organization | TAS | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006335 | DNA replication-dependent nucleosome assembly | IDA | 14718166 |
GO:0007596 | blood coagulation | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | LOC488307 30 |
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Rat (Rattus norvegicus) |
Mammalia | LOC684819 30 |
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Mouse (Mus musculus) |
Mammalia | Hist1h3e 30 |
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H3c6 17 |
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Chimpanzee (Pan troglodytes) |
Mammalia | LOC471876 30 |
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Cow (Bos Taurus) |
Mammalia | LOC517139 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486113 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC100000930 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33866 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1057519904 | Likely Pathogenic: Brainstem glioma; Squamous cell carcinoma of the head and neck | 27,872,233(-) | T/A | MISSENSE_VARIANT | |
rs1057519905 | Likely Pathogenic: Brainstem glioma; Squamous cell carcinoma of the head and neck | 27,872,234(-) | T/C | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
adult infiltrating astrocytic neoplasm |
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childhood brain stem glioma |
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brain stem cancer |
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glioma |
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tonsil squamous cell carcinoma |
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