Aliases for H3.Y Gene
Previous GeneCards Identifiers for H3.Y Gene
GeneCards Summary for H3.Y Gene
H3.Y (Histone Cluster 2, H3c Pseudogene) is a Protein Coding gene. An important paralog of this gene is ENSG00000268799.
UniProtKB/Swiss-Prot for H3.Y Gene
Primate-specific variant histone H3, which constitutes a core component of nucleosomes (PubMed:20819935, PubMed:27016736). Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access (PubMed:27016736). Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes (PubMed:27016736). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable).