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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]
H3-5 (H3.5 Histone) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H3-3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0031492 | nucleosomal DNA binding | IDA | 21274551 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005694 | chromosome | IEA | -- |
GO:0005719 | nuclear euchromatin | IDA | 21274551 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030307 | positive regulation of cell growth | IMP | 21274551 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | H3F3C 30 |
|
||
Cow (Bos Taurus) |
Mammalia | H3F3A 31 |
|
OneToOne | |
LOC100297725 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | H3f3b 31 |
|
ManyToMany | |
Gm12657 30 17 |
|
||||
Dog (Canis familiaris) |
Mammalia | H3F3C 31 |
|
OneToOne | |
LOC612779 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | H3-IX 31 |
|
ManyToMany | |
H3F3C 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731074 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | h3f3a 31 |
|
OneToOne | |
h3f3c 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | His3.3B 31 |
|
ManyToMany | |
His3:CG33839 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | his-71 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHT2 31 |
|
ManyToMany | |
HHT1 30 31 |
|
ManyToMany | |||
CSE4 33 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER013W 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1064 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01635 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hht2 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3759295 | - | p.His39Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3580219 | CNV | loss | 25503493 |
nsv519112 | CNV | loss | 19592680 |
nsv522362 | CNV | loss | 19592680 |
nsv523907 | CNV | loss | 19592680 |
nsv558100 | CNV | gain | 21841781 |
nsv558101 | CNV | gain | 21841781 |
nsv558138 | CNV | loss | 21841781 |
nsv663 | CNV | deletion | 18451855 |
nsv8940 | CNV | gain | 18304495 |
nsv983306 | CNV | duplication | 23825009 |
No disorders were found for H3-5 Gene.