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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...
Aliases for H3-5 Gene
Aliases for H3-5 Gene
External Ids for H3-5 Gene
- HGNC: 33164
- NCBI Entrez Gene: 440093
- Ensembl: ENSG00000188375
- OMIM®: 616134
- UniProtKB/Swiss-Prot: Q6NXT2
Previous HGNC Symbols for H3-5 Gene
- H3F3C
Summaries for H3-5 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]
GeneCards Summary for H3-5 Gene
H3-5 (H3.5 Histone) is a Protein Coding gene. Among its related pathways are Shigellosis and Transcriptional misregulation in cancer. An important paralog of this gene is H3-3A.
UniProtKB/Swiss-Prot Summary for H3-5 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Additional gene information for H3-5 Gene
- HGNC (33164)
- NCBI Entrez Gene (440093)
- Ensembl (ENSG00000188375)
- OMIM® (616134)
- UniProtKB/Swiss-Prot (Q6NXT2)
- Open Targets Platform(ENSG00000188375)
- Search for H3-5 at DataMed
- Search for H3-5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H3-5 Gene
Genomics for H3-5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H3-5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H3-5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H3-5
Genomic Locations for H3-5 Gene
Latest Assembly
- chr12:31,791,185-31,792,298
- (GRCh38/hg38)
- Size:
- 1,114 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:31,944,119-31,945,232
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 1,114 bases
- Orientation:
- Minus strand
- chr12:31,944,123-31,945,175
- (GRCh37/hg19 by Ensembl)
- Size:
- 1,053 bases
- Orientation:
- Minus strand
Genomic View for H3-5 Gene
Genes around H3-5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by HGNC
- 12p11.21 by Entrez Gene
- 12p11.21 by Ensembl
H3-5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H3-5 Gene
Proteins for H3-5 Gene
-
Protein details for H3-5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6NXT2-H3C_HUMAN
- Recommended name:
- Histone H3.3C
- Protein Accession:
- Q6NXT2
- E9P281
Protein attributes for H3-5 Gene
- Size:
- 135 amino acids
- Molecular mass:
- 15214 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H3-5 Gene
- Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-122 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
- Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
- Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
- Methylation at Lys-5 (H3K4me) is linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) requires preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-56 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).
- Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-41 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
- Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity).
- Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
- Succinylated. Desuccinylation at Lys-122 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
- Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for H3-5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for H3-5
- Invitrogen Antibodies for H3-5 (AFLGC-H3-5)
- antibodies-online: Show 36 available Histone H3.3C Antibodies ranked by validation data
Protein products for research
-
OriGene Purified Proteins for H3-5
- Search Origene for MassSpec and Protein Over-expression Lysates for H3-5
- Origene Custom Protein Services for H3-5
- Novus Biologicals lysates for H3-5
Assay products for research
No data available for DME Specific Peptides for H3-5 Gene
Domains & Families for H3-5 Gene
Gene Families for H3-5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for H3-5 Gene
- InterPro:
- Blocks:
-
- Histone H3
- ProtoNet:
Suggested Antigen Peptide Sequences for H3-5 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone variant H3.5 (E9P281_HUMAN)
- Histone H3.3C (H3C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6NXT2- Family:
-
- Belongs to the histone H3 family.
Function for H3-5 Gene
Molecular function for H3-5 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Phenotypes From GWAS Catalog for H3-5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0031492 | nucleosomal DNA binding | IDA | 21274551 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H3-5 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H3-5 - Starting at $85 >
- * H3-5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H3-5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3-5
miRNA for H3-5 Gene
- miRTarBase miRNAs that target H3-5
-
- hsa-miR-1-3p (MIRT023723)
- hsa-miR-527 (MIRT475863)
- hsa-miR-518a-5p (MIRT475864)
- hsa-miR-548aw (MIRT475865)
- hsa-miR-3613-5p (MIRT475866)
- hsa-miR-1468-3p (MIRT475867)
- hsa-miR-548x-5p (MIRT475868)
- hsa-miR-548g-5p (MIRT475869)
- hsa-miR-548f-5p (MIRT475870)
- hsa-miR-548aj-5p (MIRT475871)
- hsa-miR-3614-5p (MIRT475872)
- hsa-miR-4725-5p (MIRT475873)
- hsa-miR-890 (MIRT475874)
- hsa-miR-6816-3p (MIRT475875)
- hsa-miR-137 (MIRT475876)
- hsa-miR-363-3p (MIRT475877)
- hsa-miR-92a-3p (MIRT475878)
- hsa-miR-92b-3p (MIRT475879)
- hsa-miR-25-3p (MIRT475880)
- hsa-miR-32-5p (MIRT475881)
- hsa-miR-367-3p (MIRT475882)
- hsa-miR-10a-5p (MIRT475883)
- hsa-miR-10b-5p (MIRT475884)
- hsa-miR-4765 (MIRT475885)
- hsa-miR-1200 (MIRT475886)
- hsa-miR-1236-5p (MIRT475887)
- hsa-miR-544b (MIRT475888)
- hsa-miR-4324 (MIRT475889)
- hsa-miR-4793-5p (MIRT475890)
- hsa-miR-5196-3p (MIRT475891)
- hsa-miR-4662b (MIRT475892)
- hsa-miR-4647 (MIRT475893)
- hsa-miR-4426 (MIRT475894)
- hsa-miR-206 (MIRT475895)
- hsa-miR-613 (MIRT475896)
- hsa-miR-4328 (MIRT493690)
- hsa-miR-3591-5p (MIRT557380)
- hsa-miR-4777-5p (MIRT557381)
- hsa-miR-526a (MIRT557382)
- hsa-miR-523-5p (MIRT557383)
- hsa-miR-522-5p (MIRT557384)
- hsa-miR-520c-5p (MIRT557385)
- hsa-miR-519c-5p (MIRT557386)
- hsa-miR-519b-5p (MIRT557387)
- hsa-miR-519a-5p (MIRT557388)
- hsa-miR-518f-5p (MIRT557389)
- hsa-miR-518e-5p (MIRT557390)
- hsa-miR-518d-5p (MIRT557391)
- hsa-miR-340-5p (MIRT557392)
- hsa-miR-142-3p (MIRT557393)
- hsa-miR-938 (MIRT557394)
- hsa-miR-1233-3p (MIRT557395)
- hsa-miR-520g-5p (MIRT557396)
- hsa-miR-361-3p (MIRT557397)
- hsa-miR-3163 (MIRT557398)
- hsa-miR-4255 (MIRT557399)
- hsa-miR-129-2-3p (MIRT557400)
- hsa-miR-129-1-3p (MIRT557401)
- hsa-miR-605-5p (MIRT557402)
- hsa-miR-5692a (MIRT557403)
- hsa-miR-4668-3p (MIRT557404)
- hsa-miR-6801-5p (MIRT572015)
- hsa-miR-3171 (MIRT572016)
- hsa-miR-499b-5p (MIRT572017)
- hsa-miR-4494 (MIRT572018)
- hsa-miR-27b-3p (MIRT572019)
- hsa-miR-27a-3p (MIRT572020)
- hsa-miR-128-3p (MIRT572021)
- hsa-miR-3681-3p (MIRT572022)
- hsa-miR-216a-3p (MIRT572023)
- hsa-miR-5003-3p (MIRT749389)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3-5
- Browse OriGene Inhibitory RNA Products For H3-5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3-5
Clone products for research
- Applied Biological Materials (abm): Clones for H3-5 - Starting at $45 >
- * H3-5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H3-5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3-5
Cell Lines for research
-
Horizon Cell Lines for H3-5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H3-5 Gene
Localization for H3-5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H3-5 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000791 | euchromatin | IDA | 21274551 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H3-5 Gene
Pathways & Interactions for H3-5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
|
| 2 | Shigellosis | ||
| 3 | Transcriptional misregulation in cancer | ||
Pathways by source for H3-5 Gene
5 KEGG pathways for H3-5 Gene
Interacting Proteins for H3-5 Gene
Selected Interacting proteins:
Q6NXT2-H3C_HUMAN
ENSP00000339835
for H3-5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H3-5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030307 | positive regulation of cell growth | IMP | 21274551 |
No data available for SIGNOR curated interactions for H3-5 Gene
Transcripts for H3-5 Gene
mRNA/cDNA for H3-5 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000340398 1114 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H3-5 - Starting at $85 >
- * H3-5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H3-5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H3-5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H3-5
- Browse OriGene Inhibitory RNA Products For H3-5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3-5
Clone products for research
- Applied Biological Materials (abm): Clones for H3-5 - Starting at $45 >
- * H3-5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H3-5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H3-5
Relevant External Links for H3-5 Gene
- GeneLoc Exon Structure for
- H3-5
Expression for H3-5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H3-5
SOURCE GeneReport for Unigene cluster for H3-5 Gene:
Hs.448697mRNA Expression by UniProt/SwissProt for H3-5 Gene:
Q6NXT2-H3C_HUMAN
Tissue specificity:
Specifically expressed in the seminiferous tubules of testis.
Evidence on tissue expression from TISSUES for H3-5 Gene
- Nervous system(4.2)
- Pancreas(3.4)
- Skin(3)
- Blood(2.9)
- Spleen(2.6)
- Eye(2.3)
- Lung(2.2)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for H3-5
-
OriGene qPCR primer pairs and template standards for H3-5
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for H3-5 Gene
Orthologs for H3-5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | H3F3C 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | H3F3A 31 |
|
OneToOne | |
| LOC100297725 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | H3f3b 31 |
|
ManyToMany | |
| Gm12657 30 17 |
|
||||
| Dog (Canis familiaris) |
Mammalia | H3F3C 31 |
|
OneToOne | |
| LOC612779 30 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | H3-IX 31 |
|
ManyToMany | |
| H3F3C 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731074 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | h3f3a 31 |
|
OneToOne | |
| h3f3c 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | His3.3B 31 |
|
ManyToMany | |
| His3:CG33839 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | his-71 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHT2 31 |
|
ManyToMany | |
| HHT1 30 31 |
|
ManyToMany | |||
| CSE4 33 |
|
|
|||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER013W 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1064 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01635 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hht2 30 |
|
- Species where no ortholog for H3-5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for H3-5 Gene
- ENSEMBL:
- Gene Tree for H3-5 (if available)
- TreeFam:
- Gene Tree for H3-5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H3-5: view image
Paralogs for H3-5 Gene
Variants for H3-5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H3-5 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3759295 | - |
p.His39Arg |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3580219 | CNV | loss | 25503493 |
| nsv519112 | CNV | loss | 19592680 |
| nsv522362 | CNV | loss | 19592680 |
| nsv523907 | CNV | loss | 19592680 |
| nsv558100 | CNV | gain | 21841781 |
| nsv558101 | CNV | gain | 21841781 |
| nsv558138 | CNV | loss | 21841781 |
| nsv663 | CNV | deletion | 18451855 |
| nsv8940 | CNV | gain | 18304495 |
| nsv983306 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.73;
73.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H3-5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H3-5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H3-5 Gene
Disorders for H3-5 Gene
Additional Disease Information for H3-5
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for H3-5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H3-5 Gene
Publications for H3-5 Gene
- H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes. (PMID: 21274551) Schenk R … Postberg J (Chromosoma 2011) 2 3 4
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for H3-5 Gene
- Custom Antibody ServicesOriGene Antibodies for H3-5
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- Invitrogen Antibodies for H3-5 (AFLGC-H3-5)
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Sources for H3-5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB