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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015]
H3-3B (H3.3 Histone B) is a Protein Coding gene. Diseases associated with H3-3B include Chondroblastoma and Bone Giant Cell Sarcoma. Among its related pathways are Cellular Senescence (REACTOME) and Meiosis. An important paralog of this gene is H3-3A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IDA | 19633671 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | 19633671 |
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19494831 |
GO:0031492 | nucleosomal DNA binding | IDA,IBA | 19633671 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000784 | nuclear chromosome, telomeric region | IDA | 20110566 |
GO:0000786 | nucleosome | IDA,IEA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 19633671 |
GO:0001740 | Barr body | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Mitotic Prophase |
.57
|
|
5 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0001649 | osteoblast differentiation | IEA | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
GO:0006997 | nucleus organization | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
cow (Bos Taurus) |
Mammalia | H3F3A 33 |
|
OneToOne | |
H3F3B 32 |
|
||||
mouse (Mus musculus) |
Mammalia | H3f3a 33 |
|
OneToOne | |
H3f3b 17 32 |
|
||||
chimpanzee (Pan troglodytes) |
Mammalia | H3F3C 33 |
|
OneToOne | |
H3F3B 32 |
|
||||
oppossum (Monodelphis domestica) |
Mammalia | H3F3B 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | H3F3B 33 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | H3f3b 32 |
|
||
dog (Canis familiaris) |
Mammalia | H3F3B 33 32 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | H3-IX 33 |
|
OneToOne | |
H3F3B 32 |
|
||||
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101730642 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | h3f3a 33 |
|
OneToMany | |
H3F3B (1 of 3) 33 |
|
OneToMany | |||
H3F3B (3 of 3) 33 |
|
OneToMany | |||
LOC565028 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | His3.3A 33 |
|
OneToOne | |
His3:CG33857 32 |
|
||||
worm (Caenorhabditis elegans) |
Secernentea | his-71 33 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHT2 33 |
|
ManyToMany | |
HHT1 33 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1064 33 |
|
OneToOne |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1555585486 | uncertain-significance, Inborn genetic diseases | 75,779,056(-) | T/C | coding_sequence_variant, missense_variant | |
rs1555585522 | uncertain-significance, Inborn genetic diseases | 75,779,152(-) | G/A | coding_sequence_variant, missense_variant | |
rs1000160446 | -- | 75,778,942(-) | T/C/G | coding_sequence_variant, synonymous_variant | |
rs1000377083 | -- | 75,781,318(-) | G/A | upstream_transcript_variant | |
rs1000757772 | -- | 75,776,676(-) | T/A | 3_prime_UTR_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
chondroblastoma |
|
|
bone giant cell sarcoma |
|
|
brain stem cancer |
|
|
malignant giant cell tumor |
|
|
adult oligodendroglioma |
|
|