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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015]
H3-3B (H3.3 Histone B) is a Protein Coding gene. Diseases associated with H3-3B include Chondroblastoma and Clear Cell Chondrosarcoma. Among its related pathways are Transcriptional misregulation in cancer and Signaling by GPCR. An important paralog of this gene is H3-3A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19633671 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IDA | 19633671 |
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19494831 |
GO:0031492 | nucleosomal DNA binding | IDA | 19633671 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000784 | nuclear chromosome, telomeric region | IDA | 20110566 |
GO:0000786 | nucleosome | IEA,IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 19633671 |
GO:0001740 | Barr body | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Mitotic Prophase |
.57
|
|
5 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Development Notch Signaling Pathway
.55
Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
|
Transcription Sin3 and NuRD in transcription regulation
.31
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0001649 | osteoblast differentiation | IEA | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
GO:0006997 | nucleus organization | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | H3f3a 17 31 |
|
OneToOne | |
H3f3b 30 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | H3F3B 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | H3F3A 31 |
|
OneToOne | |
H3F3B 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | H3F3B 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | H3F3C 31 |
|
OneToOne | |
H3F3B 30 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | H3f3b 30 |
|
||
Dog (Canis familiaris) |
Mammalia | H3F3B 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | H3-IX 31 |
|
OneToOne | |
H3F3B 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101730642 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | h3f3a 31 |
|
OneToMany | |
H3F3B (1 of 3) 31 |
|
OneToMany | |||
H3F3B (3 of 3) 31 |
|
OneToMany | |||
LOC565028 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | His3.3A 31 |
|
OneToOne | |
His3:CG33857 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | his-71 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHT2 31 |
|
ManyToMany | |
HHT1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1064 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1555585486 | Uncertain Significance: Inborn genetic diseases | 75,779,056(-) | T/C | MISSENSE_VARIANT | |
rs1555585522 | Uncertain Significance: Inborn genetic diseases | 75,779,152(-) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
chondroblastoma |
|
|
clear cell chondrosarcoma |
|
|
bone giant cell sarcoma |
|
|
malignant giant cell tumor |
|
|
childhood brain stem glioma |
|
|