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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]
H3-3A (H3.3 Histone A) is a Protein Coding gene. Diseases associated with H3-3A include Glioma Susceptibility 1 and Chondroblastoma. Among its related pathways are Transcriptional misregulation in cancer and Signaling by GPCR. An important paralog of this gene is H3-3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19633671 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IDA | 19633671 |
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19494831 |
GO:0031492 | nucleosomal DNA binding | IDA | 19633671 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 14718166 |
GO:0000784 | nuclear chromosome, telomeric region | IDA | 20110566 |
GO:0000786 | nucleosome | IDA | 21636898 |
GO:0000788 | nuclear nucleosome | IDA | 19633671 |
GO:0001740 | Barr body | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Mitotic Prophase |
.57
|
|
5 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Development Notch Signaling Pathway
.55
Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
|
Transcription Sin3 and NuRD in transcription regulation
.31
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000183 | chromatin silencing at rDNA | TAS | -- |
GO:0001649 | osteoblast differentiation | IEA | -- |
GO:0006334 | nucleosome assembly | IMP | 25615412 |
GO:0006336 | DNA replication-independent nucleosome assembly | IDA | 14718166 |
GO:0006997 | nucleus organization | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H3A 30 |
|
||
H3F3C 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | H3F3A 30 |
|
||
H3F3C 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | H3F3B 30 |
|
||
-- 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | H3f3a 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | LOC100361558 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | H3-IX 31 |
|
OneToOne | |
LOC100859629 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | H3F3A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101730642 30 |
|
||
Str.6553 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8034 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | H3F3A 31 |
|
OneToOne | |
LOC565028 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | His3:CG33857 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | his-71 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HHT2 31 |
|
ManyToMany | |
HHT1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1064 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
690374 | Uncertain Significance: not provided | 226,071,433(+) | C/T | MISSENSE_VARIANT | |
916527 | Uncertain Significance: not provided | 226,065,658(+) | C/T | MISSENSE_VARIANT | |
rs1057519902 | Likely Pathogenic: Adrenocortical carcinoma; Brainstem glioma; Neoplasm of brain; Glioblastoma | 226,064,451(+) | G/C | MISSENSE_VARIANT | |
rs1057519903 | Likely Pathogenic: Astrocytoma; Brainstem glioma. Glioma (GLM) [MIM:137800] | 226,064,434(+) | A/Tp.Lys28Met | MISSENSE_VARIANT | |
rs1131691704 | Uncertain Significance: not provided | 226,064,439(+) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
glioma susceptibility 1 |
|
|
chondroblastoma |
|
|
malignant giant cell tumor |
|
|
clear cell chondrosarcoma |
|
|
spinal cord glioma |
|
|