Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in ... See more...

Aliases for H3-2 Gene

Aliases for H3-2 Gene

  • H3.2 Histone (Putative) 2 3 13
  • Histone Cluster 2 H3 Pseudogene 2 2 3 5
  • HIST2H3PS2 3 5 13
  • Histone 2, H3, Pseudogene 2 2 3
  • Histone Cluster 2, H3, Pseudogene 2 2
  • Histone H3 13
  • P06 3

External Ids for H3-2 Gene

Previous HGNC Symbols for H3-2 Gene

  • HIST2H3PS2

Summaries for H3-2 Gene

Entrez Gene Summary for H3-2 Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a member of the H3 family, but is found outside of the histone cluster. There is evidence that it is transcribed and has an intact CDS, but residue changes in the protein suggest that it may be on its way to becoming a psuedogene. [provided by RefSeq, Aug 2019]

GeneCards Summary for H3-2 Gene

H3-2 (H3.2 Histone (Putative)) is a Protein Coding gene. Diseases associated with H3-2 include Asymmetric Motor Neuropathy and Chromosome 16P13.3 Deletion Syndrome, Proximal. An important paralog of this gene is H3C2.

Gene Wiki entry for H3-2 Gene

Additional gene information for H3-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H3-2 Gene

Genomics for H3-2 Gene

GeneHancer (GH) Regulatory Elements for H3-2 Gene

Promoters and enhancers for H3-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J143903 Promoter/Enhancer 1 Ensembl ENCODE CraniofacialAtlas 500.7 +1.6 1566 4.8 CTCF ZBTB33 ENSG00000230186 ENSG00000234571 H2BP2 H3-2 NONHSAG002609.2 lnc-HIST2H3PS2-4 piR-30912-002
GH01J143899 Enhancer 0.2 Ensembl 0.4 +6.2 6165 0.4 ENSG00000234571 NONHSAG002609.2 H3-2 lnc-HIST2H3PS2-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H3-2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H3-2

Genomic Locations for H3-2 Gene

Genomic Locations for H3-2 Gene
chr1:143,894,544-143,905,966
(GRCh38/hg38)
Size:
11,423 bases
Orientation:
Minus strand
chr1:149,398,877-149,400,540
(GRCh37/hg19)
Size:
1,664 bases
Orientation:
Minus strand

Genomic View for H3-2 Gene

Genes around H3-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H3-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H3-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H3-2 Gene

Proteins for H3-2 Gene

  • Protein details for H3-2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A590UJL8-A0A590UJL8_HUMAN
    Recommended name:
    H3.2 histone (putative)
    Protein Accession:
    A0A590UJL8

    Protein attributes for H3-2 Gene

    Size:
    79 amino acids
    Molecular mass:
    9155 Da
    Quaternary structure:
    No Data Available
  • Protein details for H3-2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q5TEC6-Q5TEC6_HUMAN
    Recommended name:
    Histone H3
    Protein Accession:
    Q5TEC6

    Protein attributes for H3-2 Gene

    Size:
    136 amino acids
    Molecular mass:
    15430 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for H3-2 Gene

neXtProt entry for H3-2 Gene

Post-translational modifications for H3-2 Gene

No Post-translational modifications

Other Protein References for H3-2 Gene

No data available for DME Specific Peptides for H3-2 Gene

Domains & Families for H3-2 Gene

Gene Families for H3-2 Gene

Unknown:
  • Belongs to the histone H3 family.
  • Belongs to the histone H3 family.
HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H3-2 Gene

genes like me logo Genes that share domains with H3-2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for H3-2 Gene

Function for H3-2 Gene

Gene Ontology (GO) - Molecular Function for H3-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H3-2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3-2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H3-2 Gene

Localization for H3-2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H3-2 gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 3
cytoskeleton 3
mitochondrion 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for H3-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H3-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for H3-2 Gene

Pathways & Interactions for H3-2 Gene

PathCards logo

SuperPathways for H3-2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for H3-2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for H3-2 Gene

Drugs & Compounds for H3-2 Gene

No Compound Related Data Available

Transcripts for H3-2 Gene

mRNA/cDNA for H3-2 Gene

3 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H3-2

Alternative Splicing Database (ASD) splice patterns (SP) for H3-2 Gene

No ASD Table

Relevant External Links for H3-2 Gene

GeneLoc Exon Structure for
H3-2

Expression for H3-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H3-2

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H3-2 Gene

Orthologs for H3-2 Gene

Evolution for H3-2 Gene

ENSEMBL:
Gene Tree for H3-2 (if available)
TreeFam:
Gene Tree for H3-2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H3-2: view image

No data available for Orthologs for H3-2 Gene

Paralogs for H3-2 Gene

genes like me logo Genes that share paralogs with H3-2: view

Variants for H3-2 Gene

Additional dbSNP identifiers (rs#s) for H3-2 Gene

Variation tolerance for H3-2 Gene

Gene Damage Index Score: 2.86; 48.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H3-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H3-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for H3-2 Gene

Disorders for H3-2 Gene

MalaCards: The human disease database

(29) MalaCards diseases for H3-2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
asymmetric motor neuropathy
chromosome 16p13.3 deletion syndrome, proximal
  • rsts
kleefstra syndrome 1
  • klefs1
weaver syndrome
  • wvs
alpha thalassemia-x-linked intellectual disability syndrome
  • alpha-thalassemia/mental retardation syndrome, nondeletion type
- elite association - COSMIC cancer census association via MalaCards
Search H3-2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for H3-2

genes like me logo Genes that share disorders with H3-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H3-2 Gene

Publications for H3-2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 13 54
  2. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54

Products for H3-2 Gene

Sources for H3-2 Gene