Aliases for H2BS1 Gene
External Ids for H2BS1 Gene
Previous HGNC Symbols for H2BS1 Gene
GeneCards Summary for H2BS1 Gene
H2BS1 (H2B.S Histone 1) is a Protein Coding gene. Diseases associated with H2BS1 include Autosomal Recessive Alport Syndrome and Endometrial Stromal Sarcoma. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA Damage/Telomere Stress Induced Senescence. An important paralog of this gene is LOC102724334.
UniProtKB/Swiss-Prot Summary for H2BS1 Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.