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Aliases for H2BFWT Gene

Aliases for H2BFWT Gene

  • H2B Histone Family Member W, Testis Specific 2 3 5
  • H2B Histone Family, Member W, Testis-Specific 2
  • H2B Histone Family Member W Testis-Specific 4

External Ids for H2BFWT Gene

Previous GeneCards Identifiers for H2BFWT Gene

  • GC0XM102038
  • GC0XM103071
  • GC0XM103153
  • GC0XM103265
  • GC0XM092921

Summaries for H2BFWT Gene

Entrez Gene Summary for H2BFWT Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]

GeneCards Summary for H2BFWT Gene

H2BFWT (H2B Histone Family Member W, Testis Specific) is a Protein Coding gene. Diseases associated with H2BFWT include Male Infertility. Among its related pathways are Viral carcinogenesis and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2BFM.

UniProtKB/Swiss-Prot for H2BFWT Gene

  • Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.

Additional gene information for H2BFWT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2BFWT Gene

Genomics for H2BFWT Gene

GeneHancer (GH) Regulatory Elements for H2BFWT Gene

Promoters and enhancers for H2BFWT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI104013 Promoter 0.5 EPDnew 550.8 0.0 -41 0.1 H2BFWT GC0XP104018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around H2BFWT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the H2BFWT gene promoter:

Genomic Locations for H2BFWT Gene

Genomic Locations for H2BFWT Gene
2,541 bases
Minus strand

Genomic View for H2BFWT Gene

Genes around H2BFWT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BFWT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BFWT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BFWT Gene

Proteins for H2BFWT Gene

  • Protein details for H2BFWT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H2B type W-T
    Protein Accession:
    Secondary Accessions:
    • B1AK72
    • Q147W3

    Protein attributes for H2BFWT Gene

    175 amino acids
    Molecular mass:
    19618 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.
    • Ortholog in primates, but not in rodents.

neXtProt entry for H2BFWT Gene

Post-translational modifications for H2BFWT Gene

No Post-translational modifications

Other Protein References for H2BFWT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BFWT Gene

Domains & Families for H2BFWT Gene

Gene Families for H2BFWT Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H2BFWT Gene

Suggested Antigen Peptide Sequences for H2BFWT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the histone H2B family.
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BFWT: view

Function for H2BFWT Gene

Molecular function for H2BFWT Gene

UniProtKB/Swiss-Prot Function:
Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.

Gene Ontology (GO) - Molecular Function for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BFWT: view

Phenotypes for H2BFWT Gene

GenomeRNAi human phenotypes for H2BFWT:
genes like me logo Genes that share phenotypes with H2BFWT: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BFWT Gene

Localization for H2BFWT Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BFWT Gene

Nucleus membrane. Chromosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2BFWT gene
Compartment Confidence
nucleus 4
mitochondrion 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0016020 membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with H2BFWT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H2BFWT Gene

Pathways & Interactions for H2BFWT Gene

genes like me logo Genes that share pathways with H2BFWT: view

Pathways by source for H2BFWT Gene

Gene Ontology (GO) - Biological Process for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA --
genes like me logo Genes that share ontologies with H2BFWT: view

No data available for SIGNOR curated interactions for H2BFWT Gene

Drugs & Compounds for H2BFWT Gene

No Compound Related Data Available

Transcripts for H2BFWT Gene

mRNA/cDNA for H2BFWT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H2BFWT Gene

H2B histone family, member W, testis-specific:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BFWT Gene

No ASD Table

Relevant External Links for H2BFWT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for H2BFWT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for H2BFWT Gene

mRNA differential expression in normal tissues according to GTEx for H2BFWT Gene

This gene is overexpressed in Testis (x40.7).

Protein differential expression in normal tissues from HIPED for H2BFWT Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for H2BFWT Gene

Protein tissue co-expression partners for H2BFWT Gene

NURSA nuclear receptor signaling pathways regulating expression of H2BFWT Gene:


SOURCE GeneReport for Unigene cluster for H2BFWT Gene:


mRNA Expression by UniProt/SwissProt for H2BFWT Gene:

Tissue specificity: Testis-specific. Present in sperm cells (at protein level).
genes like me logo Genes that share expression patterns with H2BFWT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BFWT Gene

Orthologs for H2BFWT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for H2BFWT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia H2BFWT 34
  • 97 (a)
LOC473712 33
  • 96.38 (n)
(Canis familiaris)
Mammalia H2BFWT 33
  • 68.78 (n)
-- 34
  • 55 (a)
(Bos Taurus)
Mammalia LOC523458 33
  • 67.59 (n)
-- 34
  • 49 (a)
-- 34
  • 44 (a)
-- 34
  • 43 (a)
-- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 39 (a)
-- 34
  • 37 (a)
-- 34
  • 34 (a)
-- 34
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
(Mus musculus)
Mammalia H2bfm 34
  • 25 (a)
(Gallus gallus)
Aves -- 34
  • 42 (a)
(Danio rerio)
Actinopterygii si:ch211-190p8.2 34
  • 45 (a)
zgc:92591 34
  • 45 (a)
si:dkey-108k21.11 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG17949 34
  • 44 (a)
His2B:CG33868 34
  • 44 (a)
His2B:CG33870 34
  • 44 (a)
His2B:CG33872 34
  • 44 (a)
His2B:CG33874 34
  • 44 (a)
His2B:CG33876 34
  • 44 (a)
His2B:CG33878 34
  • 44 (a)
His2B:CG33880 34
  • 44 (a)
His2B:CG33882 34
  • 44 (a)
His2B:CG33884 34
  • 44 (a)
His2B:CG33886 34
  • 44 (a)
His2B:CG33888 34
  • 44 (a)
His2B:CG33890 34
  • 44 (a)
His2B:CG33892 34
  • 44 (a)
His2B:CG33894 34
  • 44 (a)
His2B:CG33896 34
  • 44 (a)
His2B:CG33898 34
  • 44 (a)
His2B:CG33902 34
  • 44 (a)
His2B:CG33904 34
  • 44 (a)
His2B:CG33906 34
  • 44 (a)
His2B:CG33908 34
  • 44 (a)
(Caenorhabditis elegans)
Secernentea his-39 34
  • 44 (a)
his-11 34
  • 43 (a)
his-15 34
  • 43 (a)
his-29 34
  • 43 (a)
his-34 34
  • 43 (a)
his-44 34
  • 43 (a)
his-48 34
  • 42 (a)
his-58 34
  • 42 (a)
his-62 34
  • 42 (a)
his-66 34
  • 42 (a)
his-20 34
  • 41 (a)
his-22 34
  • 41 (a)
his-4 34
  • 41 (a)
his-41 34
  • 41 (a)
his-52 34
  • 41 (a)
his-8 34
  • 41 (a)
his-54 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTB1 34
  • 34 (a)
HTB2 34
  • 34 (a)
Species where no ortholog for H2BFWT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for H2BFWT Gene

Gene Tree for H2BFWT (if available)
Gene Tree for H2BFWT (if available)

Paralogs for H2BFWT Gene

Variants for H2BFWT Gene

Sequence variations from dbSNP and Humsavar for H2BFWT Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000081745 -- 104,014,665(-) A/G upstream_transcript_variant
rs1003947912 -- 104,015,626(-) G/A upstream_transcript_variant
rs1003980744 -- 104,015,348(-) G/A upstream_transcript_variant
rs1014156760 -- 104,014,201(-) C/A upstream_transcript_variant
rs1015277200 -- 104,014,907(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for H2BFWT Gene

Variant ID Type Subtype PubMed ID
nsv7453 OTHER inversion 18451855
nsv519626 CNV gain 19592680
nsv469772 CNV gain 16826518
nsv208 OTHER inversion 15895083
nsv1129090 CNV duplication 24896259
esv3577033 CNV gain 25503493
esv3577013 CNV gain 25503493
esv32549 CNV loss 17666407
esv2758880 CNV gain 17122850
esv22275 CNV gain 19812545
esv1007027 OTHER inversion 20482838
dgv63n47 OTHER inversion 21111241
dgv5n1 OTHER inversion 15895083
dgv2356e212 CNV gain 25503493

Variation tolerance for H2BFWT Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H2BFWT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2BFWT Gene

Disorders for H2BFWT Gene

MalaCards: The human disease database

(1) MalaCards diseases for H2BFWT Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for H2BFWT

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with H2BFWT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H2BFWT Gene

Publications for H2BFWT Gene

  1. Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome. (PMID: 15475252) Churikov D … Zalensky A (Genomics 2004) 2 3 4 58
  2. Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility. (PMID: 19583817) Lee J … Lee S (Journal of cellular and molecular medicine 2009) 3 44 58
  3. The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes. (PMID: 16449661) Boulard M … Dimitrov S (Molecular and cellular biology 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers. (PMID: 25731851) Shaytan AK … Panchenko AR (Current opinion in structural biology 2015) 3 58

Products for H2BFWT Gene

Sources for H2BFWT Gene

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