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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H2BC8 (H2B Clustered Histone 8) is a Protein Coding gene. Diseases associated with H2BC8 include Ehrlich Tumor Carcinoma. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2BC7.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J026214 | Promoter/Enhancer | 2.1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.6 | -597 | 7 | ARHGAP35 SP1 HNRNPL CREB1 CTCF TEAD4 REST TFE3 ZNF512 LEF1 | H2AC8 H2BC8 H3C5P piR-54826 ABT1 BTN2A1 BTN2A2 HMGN4 BTN2A3P GUSBP2 | |
GH06J026211 | Enhancer | 0.7 | Ensembl | 0.7 | +4.7 | 4691 | 1.2 | CREB1 PKNOX1 NR2C1 CTCF NCOR1 ARNT ZNF318 PBX2 POLR2A MNT | HSALNG0048742 LARP1P1 H2BC5 H1-4 H4C8 H2AC10P H2BC8 piR-54826 H4C5 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,NAS | 422550 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0042802 | identical protein binding | IPI | 25954010 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | NAS | 422550 |
GO:0005615 | extracellular space | IDA | 12860195 |
GO:0005634 | nucleus | IEA,HDA | 21630459 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
GO:0006334 | nucleosome assembly | IBA,NAS | 422550 |
GO:0016567 | protein ubiquitination | TAS | -- |
GO:0019731 | antibacterial humoral response | IDA | 12860195 |
GO:0042742 | defense response to bacterium | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC100610052 30 |
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Mouse (Mus musculus) |
Mammalia | Hist1h2bf 30 |
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||
H2bc7 17 |
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||||
Dog (Canis familiaris) |
Mammalia | LOC611482 30 |
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||
Rat (Rattus norvegicus) |
Mammalia | Hist1h2bf 30 |
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||
Cow (Bos Taurus) |
Mammalia | LOC787465 30 |
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||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL002W 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
nsv1021294 | CNV | loss | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ehrlich tumor carcinoma |
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