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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...
Aliases for H2BC8 Gene
Aliases for H2BC8 Gene
- H2B Clustered Histone 8 2 3 5
- H2B/A 2 3 4
- Histone Cluster 1 H2B Family Member G 2 3
- H2B Histone Family, Member A 2 3
- Histone H2B Type 1-C/E/F/G/I 3 4
- Histone Cluster 1, H2bg 2 3
- Histone 1, H2bg 2 3
- Histone H2B.1 A 3 4
- Histone H2B.A 3 4
- HIST1H2BG 3 4
- H2B.1A 2 3
- H2BFA 3 4
- Histone H2B.G 4
- Histone H2B.H 4
- Histone H2B.K 4
- Histone H2B.L 4
- DJ221C16.8 3
External Ids for H2BC8 Gene
- HGNC: 4746
- NCBI Entrez Gene: 8339
- Ensembl: ENSG00000273802
- OMIM®: 602798
- UniProtKB/Swiss-Prot: P62807
Previous HGNC Symbols for H2BC8 Gene
- H2BFA
- HIST1H2BG
Previous GeneCards Identifiers for H2BC8 Gene
- GC06M026832
- GC06M027057
- GC06M027316
- GC06M027823
Summaries for H2BC8 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2BC8 Gene
H2BC8 (H2B Clustered Histone 8) is a Protein Coding gene. Diseases associated with H2BC8 include Ehrlich Tumor Carcinoma. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H2BC4.
UniProtKB/Swiss-Prot Summary for H2BC8 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
-
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Additional gene information for H2BC8 Gene
- HGNC (4746)
- NCBI Entrez Gene (8339)
- Ensembl (ENSG00000273802)
- OMIM® (602798)
- UniProtKB/Swiss-Prot (P62807)
- Open Targets Platform(ENSG00000273802)
- Alliance of Genome Resources
- Search for H2BC8 at DataMed
- Search for H2BC8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC8 Gene
Genomics for H2BC8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H2BC8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J026214 | Promoter/Enhancer | 2.1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | -0.6 | -598 | 7 | BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SSRP1 ZNF592 ZMYM3 | H2AC8 H2BC8 H3C5P piR-54826 ABT1 BTN2A1 BTN2A2 HMGN4 BTN2A3P BTN3A1 | |
| GH06J026211 | Enhancer | 0.7 | Ensembl | 0.7 | +4.7 | 4691 | 1.2 | ARNT ATF1 ZNF318 POLR2A SUPT5H PKNOX1 FOXK2 ZNF384 NR2F6 MEIS2 | HSALNG0048742 MK280607-054 LARP1P1 H2BC5 H1-4 H4C8 H2AC10P H2BC8 H4C5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H2BC8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2BC8
Genomic Locations for H2BC8 Gene
Latest Assembly
- chr6:26,215,159-26,216,692
- (GRCh38/hg38)
- Size:
- 1,534 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:26,216,428-26,216,916
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 489 bases
- Orientation:
- Minus strand
Genomic View for H2BC8 Gene
Genes around H2BC8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H2BC8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H2BC8 Gene
Proteins for H2BC8 Gene
-
Protein details for H2BC8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62807-H2B1C_HUMAN
- Recommended name:
- Histone H2B type 1-C/E/F/G/I
- Protein Accession:
- P62807
- P02278
- Q3B872
- Q4VB69
- Q93078
- Q93080
Protein attributes for H2BC8 Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13906 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H2BC8 Gene
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
-
Glycosylation at Ser113
- NX_P62807 (NX_P62807-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H2BC8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Invitrogen Antibodies for H2BC8 (AFLGC-H2BC8)
- antibodies-online: Show 9 available HIST1H2BG Antibodies ranked by validation data
-
Biorbyt antibodies for H2BC8
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for H2BC8
- Origene Custom Protein Services for H2BC8
Assay products for research
No data available for DME Specific Peptides for H2BC8 Gene
Domains & Families for H2BC8 Gene
Gene Families for H2BC8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for H2BC8 Gene
- InterPro:
Suggested Antigen Peptide Sequences for H2BC8 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone H2B (B2R4S9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62807- Family:
-
- Belongs to the histone H2B family.
Function for H2BC8 Gene
Molecular function for H2BC8 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- UniProtKB/Swiss-Prot Function:
- Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Phenotypes From GWAS Catalog for H2BC8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA,NAS | 422550 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042802 | identical protein binding | IPI | 25954010 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H2BC8 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H2BC8 - Starting at $85 >
- * H2BC8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H2BC8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC8
miRNA for H2BC8 Gene
- miRTarBase miRNAs that target H2BC8
-
- hsa-miR-98-5p (MIRT027529)
- hsa-miR-615-3p (MIRT040271)
- hsa-miR-760 (MIRT396023)
- hsa-miR-6822-3p (MIRT396024)
- hsa-miR-5693 (MIRT450572)
- hsa-miR-6790-5p (MIRT450573)
- hsa-miR-4658 (MIRT450574)
- hsa-miR-4758-5p (MIRT450575)
- hsa-miR-1238-5p (MIRT450576)
- hsa-miR-3672 (MIRT450577)
- hsa-miR-6864-3p (MIRT450578)
- hsa-miR-4745-5p (MIRT450579)
- hsa-miR-4481 (MIRT450580)
- hsa-miR-4501 (MIRT450581)
- hsa-miR-873-3p (MIRT450582)
- hsa-miR-6796-3p (MIRT450583)
- hsa-miR-8081 (MIRT511711)
- hsa-miR-8057 (MIRT511712)
- hsa-miR-9-3p (MIRT511713)
- hsa-miR-4766-5p (MIRT511714)
- hsa-miR-146a-3p (MIRT511715)
- hsa-miR-1276 (MIRT511716)
- hsa-miR-7151-3p (MIRT626910)
- hsa-miR-5095 (MIRT626911)
- hsa-miR-150-5p (MIRT626912)
- hsa-miR-186-3p (MIRT626913)
- hsa-miR-520h (MIRT626914)
- hsa-miR-520g-3p (MIRT626915)
- hsa-miR-6504-3p (MIRT626916)
- hsa-miR-3159 (MIRT626917)
- hsa-miR-520e (MIRT626918)
- hsa-miR-520d-3p (MIRT626919)
- hsa-miR-520c-3p (MIRT626920)
- hsa-miR-520b (MIRT626921)
- hsa-miR-520a-3p (MIRT626922)
- hsa-miR-373-3p (MIRT626923)
- hsa-miR-372-3p (MIRT626924)
- hsa-miR-302e (MIRT626925)
- hsa-miR-302d-3p (MIRT626926)
- hsa-miR-302c-3p (MIRT626927)
- hsa-miR-302b-3p (MIRT626928)
- hsa-miR-302a-3p (MIRT626929)
- hsa-miR-93-5p (MIRT626930)
- hsa-miR-526b-3p (MIRT626931)
- hsa-miR-519d-3p (MIRT626932)
- hsa-miR-20b-5p (MIRT626933)
- hsa-miR-20a-5p (MIRT626934)
- hsa-miR-17-5p (MIRT626935)
- hsa-miR-106b-5p (MIRT626936)
- hsa-miR-106a-5p (MIRT626937)
- hsa-miR-1273f (MIRT783303)
- hsa-miR-143-3p (MIRT783802)
- hsa-miR-4708-5p (MIRT786473)
- hsa-miR-4712-3p (MIRT786503)
- hsa-miR-4770 (MIRT786687)
- hsa-miR-4775 (MIRT786722)
- hsa-miR-548a-3p (MIRT787390)
- hsa-miR-548ar-3p (MIRT787466)
- hsa-miR-548az-3p (MIRT787487)
- hsa-miR-548e-3p (MIRT787518)
- hsa-miR-548f-3p (MIRT787523)
- hsa-miR-548g-3p (MIRT787530)
- hsa-miR-590-3p (MIRT787953)
- hsa-miR-6088 (MIRT788029)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2BC8
- Browse OriGene Inhibitory RNA Products For H2BC8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC8
Clone products for research
- Applied Biological Materials (abm): Clones for H2BC8 - Starting at $45 >
- * H2BC8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H2BC8
- Addgene plasmids for H2BC8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC8
Cell Lines for research
-
Horizon Cell Lines for H2BC8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2BC8 Gene
Localization for H2BC8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H2BC8 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | NAS | 422550 |
| GO:0005615 | extracellular space | IDA | 12860195 |
| GO:0005634 | nucleus | IEA,HDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for H2BC8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for H2BC8 Gene
68 Reactome pathways for H2BC8 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
4 KEGG pathways for H2BC8 Gene
1 GeneGo (Thomson Reuters) pathway for H2BC8 Gene
- Signal transduction Activin A signaling regulation
Interacting Proteins for H2BC8 Gene
Selected Interacting proteins:
P62807-H2B1C_HUMAN
ENSP00000445633
for H2BC8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H2BC8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
| GO:0006334 | nucleosome assembly | IBA,NAS | 422550 |
| GO:0016567 | protein ubiquitination | TAS | -- |
| GO:0019731 | antibacterial humoral response | IDA | 12860195 |
| GO:0042742 | defense response to bacterium | IEA | -- |
No data available for SIGNOR curated interactions for H2BC8 Gene
Transcripts for H2BC8 Gene
mRNA/cDNA for H2BC8 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000541790 1534 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H2BC8 - Starting at $85 >
- * H2BC8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H2BC8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2BC8
- Browse OriGene Inhibitory RNA Products For H2BC8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC8
Clone products for research
- Applied Biological Materials (abm): Clones for H2BC8 - Starting at $45 >
- * H2BC8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H2BC8
- Addgene plasmids for H2BC8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC8
Relevant External Links for H2BC8 Gene
- GeneLoc Exon Structure for
- H2BC8
Expression for H2BC8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2BC8
SOURCE GeneReport for Unigene cluster for H2BC8 Gene:
Hs.591809Evidence on tissue expression from TISSUES for H2BC8 Gene
- Spleen(4.5)
- Lung(4.4)
- Intestine(2.4)
- Nervous system(2.3)
- Blood(2.3)
Primer products for research
-
OriGene qPCR primer pairs for H2BC8
-
OriGene qPCR primer pairs and template standards for H2BC8
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC8 Gene
Orthologs for H2BC8 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC100610052 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hist1h2bf 29 |
|
||
| H2bc7 16 |
|
||||
| Dog (Canis familiaris) |
Mammalia | LOC611482 29 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Hist1h2bf 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | LOC787465 29 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL002W 29 |
|
- Species where no ortholog for H2BC8 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for H2BC8 Gene
- ENSEMBL:
- Gene Tree for H2BC8 (if available)
- TreeFam:
- Gene Tree for H2BC8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H2BC8: view image
- Alliance of Genome Resources:
- Additional Orthologs for H2BC8
Paralogs for H2BC8 Gene
Variants for H2BC8 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1021294 | CNV | loss | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H2BC8 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2BC8 Gene
Disorders for H2BC8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ehrlich tumor carcinoma |
|
|
Search H2BC8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for H2BC8
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for H2BC8 Gene
Publications for H2BC8 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W … Doenecke D (Genomics 1991) 2 3 4
- Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N … Pesavento JJ (Journal of proteome research 2006) 3 4
- Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck HC … Jensen ON (Molecular & cellular proteomics : MCP 2006) 3 4
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R … Reinberg D (Cell 2006) 3 4
ExternalLinks
Products for H2BC8 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for H2BC8
- Origene Custom Protein Services for H2BC8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2BC8
- Browse OriGene Inhibitory RNA Products For H2BC8
- OriGene qPCR primer pairs for H2BC8
- OriGene qPCR primer pairs and template standards for H2BC8
- OriGene CRISPR knockouts for H2BC8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For H2BC8
- Sino Biological Human cDNA Clone for H2BC8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for H2BC8 (AFLGC-H2BC8)
- VectorBuilder Custom and pre-made DNA vectors for H2BC8 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H2BC8 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for H2BC8 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for H2BC8 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H2BC8
- Addgene plasmids for H2BC8
- antibodies-online: Show 9 available HIST1H2BG Antibodies ranked by validation data
- antibodies-online: Search results for available HIST1H2BG related products ranked by validation data
- antibodies-online: Search results for available HIST1H2BG related products ranked by validation data
- Horizon Cell Lines for H2BC8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H2BC8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC8
- Biorbyt antibodies for H2BC8
Sources for H2BC8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources