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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H2BC7 (H2B Clustered Histone 7) is a Protein Coding gene. Diseases associated with H2BC7 include Ehrlich Tumor Carcinoma. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2BC6.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J026193 | Promoter/Enhancer | 2.1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +1.3 | 1276 | 14.6 | ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629 | H2AC7 H2BC7 H3C4 ENSG00000282988 RPS10P1 ABT1 BTN2A2 BTN2A1 HMGN4 BTN2A3P |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,NAS | 422550 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0042802 | identical protein binding | IPI | 25954010 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | NAS | 422550 |
GO:0005615 | extracellular space | IDA | 12860195 |
GO:0005634 | nucleus | IEA,HDA | 21630459 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
GO:0006334 | nucleosome assembly | IBA,NAS | 422550 |
GO:0016567 | protein ubiquitination | TAS | -- |
GO:0019731 | antibacterial humoral response | IDA | 12860195 |
GO:0042742 | defense response to bacterium | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | LOC100856099 30 |
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Mouse (Mus musculus) |
Mammalia | Hist1h2be 30 |
|
||
H2bc6 17 |
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||||
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471880 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | LOC100365043 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC618012 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv375n21 | CNV | loss | 19592680 |
dgv5926n100 | CNV | gain | 25217958 |
esv3608397 | CNV | loss | 21293372 |
esv3608398 | CNV | loss | 21293372 |
esv3608399 | CNV | gain | 21293372 |
nsv1021294 | CNV | loss | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
nsv969356 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ehrlich tumor carcinoma |
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