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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H2BC6 (H2B Clustered Histone 6) is a Protein Coding gene. Diseases associated with H2BC6 include Ehrlich Tumor Carcinoma. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2BC7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,NAS | 422550 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0042802 | identical protein binding | IPI | 25954010 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | NAS | 422550 |
GO:0005615 | extracellular space | IDA | 12860195 |
GO:0005634 | nucleus | IEA,HDA | 21630459 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
GO:0006334 | nucleosome assembly | IBA,NAS | 422550 |
GO:0016567 | protein ubiquitination | TAS | -- |
GO:0019731 | antibacterial humoral response | IDA | 12860195 |
GO:0042742 | defense response to bacterium | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Hist1h2bl 30 |
|
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H2bc13 17 |
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Dog (Canis familiaris) |
Mammalia | LOC100856116 30 |
|
||
Cow (Bos Taurus) |
Mammalia | HIST1H2BL 30 |
|
||
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471883 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv375n21 | CNV | loss | 19592680 |
dgv5926n100 | CNV | gain | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
nsv970084 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ehrlich tumor carcinoma |
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