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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H2BC3 (H2B Clustered Histone 3) is a Protein Coding gene. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2BC21.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J026042 | Promoter/Enhancer | 2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -1.0 | -978 | 5 | SP1 HNRNPL CREB1 GATAD2A REST TFE3 SOX13 NFKBIZ POLR2A RCOR2 | H2AC5P H2BC3 H3C3 lnc-HIST1H3C-1 ENSG00000272462 ABT1 BTN2A2 HMGN4 BTN2A3P BTN3A2 | |
GH06J026037 | Enhancer | 0.4 | Ensembl dbSUPER | 0.4 | +5.7 | 5712 | 0.8 | TRIM24 | ENSG00000272462 H2AC4 H2BC3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA,NAS | 9439656 |
GO:0005515 | protein binding | IPI | 22720776 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0000786 | nucleosome | NAS | 9439656 |
GO:0005634 | nucleus | IEA,IDA | 16319397 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006334 | nucleosome assembly | IBA,NAS | 9439656 |
GO:0016567 | protein ubiquitination | TAS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Hist1h2bb 30 |
|
||
H2bc3 17 |
|
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Dog (Canis familiaris) |
Mammalia | LOC100855574 30 |
|
||
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2BB 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | LOC102549061 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC614206 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
esv3608392 | CNV | gain | 21293372 |
nsv1023453 | CNV | gain | 25217958 |
nsv1026692 | CNV | loss | 25217958 |
nsv428137 | CNV | loss | 18775914 |
nsv509122 | CNV | insertion | 20534489 |
nsv970081 | CNV | duplication | 23825009 |
No disorders were found for H2BC3 Gene.