Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...

Aliases for H2BC21 Gene

Aliases for H2BC21 Gene

  • H2B Clustered Histone 21 2 3
  • Histone Cluster 2 H2B Family Member E 2 3 5
  • H2B Histone Family, Member Q 2 3
  • Histone Cluster 2, H2be 2 3
  • Histone H2B Type 2-E 3 4
  • Histone H2B-GL105 3 4
  • Histone 2, H2be 2 3
  • Histone H2B.Q 3 4
  • HIST2H2BE 3 5
  • H2BFQ 3 4
  • H2BGL105 3
  • GL105 3
  • H2B.1 3
  • H2B/Q 4
  • H2BQ 3
  • H2B 3

External Ids for H2BC21 Gene

Previous HGNC Symbols for H2BC21 Gene

  • H2B
  • H2BFQ
  • HIST2H2BE

Previous GeneCards Identifiers for H2BC21 Gene

  • GC01M149885

Summaries for H2BC21 Gene

Entrez Gene Summary for H2BC21 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]

GeneCards Summary for H2BC21 Gene

H2BC21 (H2B Clustered Histone 21) is a Protein Coding gene. Diseases associated with H2BC21 include Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked and Vaccinia. Among its related pathways are Metabolism of proteins and Signaling by Wnt. An important paralog of this gene is H2BC6.

UniProtKB/Swiss-Prot Summary for H2BC21 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for H2BC21 Gene

Additional gene information for H2BC21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC21 Gene

Genomics for H2BC21 Gene

GeneHancer (GH) Regulatory Elements for H2BC21 Gene

Promoters and enhancers for H2BC21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H2BC21 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2BC21

Genomic Locations for H2BC21 Gene

Genomic Locations for H2BC21 Gene
chr1:149,884,459-149,886,682
(GRCh38/hg38)
Size:
2,224 bases
Orientation:
Minus strand
chr1:149,856,010-149,858,232
(GRCh37/hg19)
Size:
2,223 bases
Orientation:
Minus strand

Genomic View for H2BC21 Gene

Genes around H2BC21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BC21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BC21 Gene

Proteins for H2BC21 Gene

  • Protein details for H2BC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16778-H2B2E_HUMAN
    Recommended name:
    Histone H2B type 2-E
    Protein Accession:
    Q16778
    Secondary Accessions:
    • A3KMC7
    • A8K110
    • Q4KMY1
    • Q5QNX0
    • Q9UE88

    Protein attributes for H2BC21 Gene

    Size:
    126 amino acids
    Molecular mass:
    13920 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for H2BC21 Gene

neXtProt entry for H2BC21 Gene

Post-translational modifications for H2BC21 Gene

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for H2BC21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for H2BC21

No data available for DME Specific Peptides for H2BC21 Gene

Domains & Families for H2BC21 Gene

Gene Families for H2BC21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H2BC21 Gene

Suggested Antigen Peptide Sequences for H2BC21 Gene

GenScript: Design optimal peptide antigens:
  • Histone H2B.q (H2B2E_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16778

UniProtKB/Swiss-Prot:

H2B2E_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BC21: view

Function for H2BC21 Gene

Molecular function for H2BC21 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Phenotypes From GWAS Catalog for H2BC21 Gene

Gene Ontology (GO) - Molecular Function for H2BC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS,IBA 1469070
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BC21: view
genes like me logo Genes that share phenotypes with H2BC21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BC21 Gene

Localization for H2BC21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BC21 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2BC21 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 3
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for H2BC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 1469070
GO:0005615 extracellular space IDA 12860195
GO:0005634 nucleus IDA,IEA 16319397
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H2BC21: view

Pathways & Interactions for H2BC21 Gene

PathCards logo

SuperPathways for H2BC21 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with H2BC21: view

Pathways by source for H2BC21 Gene

Gene Ontology (GO) - Biological Process for H2BC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006334 nucleosome assembly IBA,NAS 1469070
GO:0019731 antibacterial humoral response IDA 12860195
GO:0042742 defense response to bacterium IEA --
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with H2BC21: view

No data available for SIGNOR curated interactions for H2BC21 Gene

Drugs & Compounds for H2BC21 Gene

(1) Drugs for H2BC21 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for H2BC21 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with H2BC21: view

Transcripts for H2BC21 Gene

mRNA/cDNA for H2BC21 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC21

Alternative Splicing Database (ASD) splice patterns (SP) for H2BC21 Gene

No ASD Table

Relevant External Links for H2BC21 Gene

GeneLoc Exon Structure for
H2BC21

Expression for H2BC21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2BC21

SOURCE GeneReport for Unigene cluster for H2BC21 Gene:

Hs.2178

Evidence on tissue expression from TISSUES for H2BC21 Gene

  • Nervous system(4.9)
  • Blood(4.7)
  • Liver(4.5)
  • Lung(4.5)
  • Spleen(3.3)
  • Bone marrow(2.8)
  • Heart(2.5)
  • Skin(2.5)
  • Lymph node(2.4)
  • Pancreas(2.2)
  • Kidney(2.1)
  • Muscle(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC21 Gene

Orthologs for H2BC21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for H2BC21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST2H2BE 31
  • 100 (a)
OneToOne
HIST1H2BD 30
  • 99.47 (n)
oppossum
(Monodelphis domestica)
Mammalia HIST2H2BE 31
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST2H2BE 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H2B 31
  • 99 (a)
ManyToMany
LOC512612 30
  • 88.62 (n)
dog
(Canis familiaris)
Mammalia LOC483170 30
  • 94.71 (n)
-- 31
  • 93 (a)
OneToMany
-- 31
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves H2B-I 31
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 94 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1950 30
zebrafish
(Danio rerio)
Actinopterygii zgc:112234 31 31 31 31 31
  • 94 (a)
ManyToMany
zgc:194989 31
  • 94 (a)
ManyToMany
wu:fe11b02 31 31 31 31 31 31 31 31
  • 94 (a)
ManyToMany
zgc:171759 31 31 31 31 31 31 31 31 31 31
  • 94 (a)
ManyToMany
ano9a 31 31
  • 94 (a)
ManyToMany
si:dkey-261m9.19 31
  • 87 (a)
ManyToMany
zgc:173587 31
  • 87 (a)
ManyToMany
si:dkey-261m9.6 31
  • 87 (a)
ManyToMany
CABZ01086354.1 31
  • 86 (a)
ManyToMany
LOC560748 30
  • 85.22 (n)
-- 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11306 30
wheat
(Triticum aestivum)
Liliopsida Ta.27708 30
rice
(Oryza sativa)
Liliopsida Os.47714 30
Species where no ortholog for H2BC21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for H2BC21 Gene

ENSEMBL:
Gene Tree for H2BC21 (if available)
TreeFam:
Gene Tree for H2BC21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H2BC21: view image

Paralogs for H2BC21 Gene

Pseudogenes.org Pseudogenes for H2BC21 Gene

genes like me logo Genes that share paralogs with H2BC21: view

Variants for H2BC21 Gene

Additional dbSNP identifiers (rs#s) for H2BC21 Gene

Structural Variations from Database of Genomic Variants (DGV) for H2BC21 Gene

Variant ID Type Subtype PubMed ID
nsv7182 OTHER inversion 18451855
nsv831525 CNV gain 17160897
nsv831537 CNV loss 17160897
nsv946382 CNV duplication 23825009

Variation tolerance for H2BC21 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H2BC21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BC21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2BC21 Gene

Disorders for H2BC21 Gene

MalaCards: The human disease database

(14) MalaCards diseases for H2BC21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alpha-thalassemia/mental retardation syndrome, x-linked
  • atrx
vaccinia
lupus erythematosus
  • systemic lupus erythematosus
alpha-thalassemia
  • thalassemia, alpha-
connective tissue disease
  • connective tissue disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for H2BC21

genes like me logo Genes that share disorders with H2BC21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H2BC21 Gene

Publications for H2BC21 Gene

  1. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PMID: 1469070) Collart D … Stein GS (Journal of cellular biochemistry 1992) 2 3 4 23 54
  2. Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck HC … Jensen ON (Molecular & cellular proteomics : MCP 2006) 3 4 23 54
  3. Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N … Pesavento JJ (Journal of proteome research 2006) 3 4 23 54
  4. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 54
  5. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PMID: 23824326) Zhang Z … Wang H (Genes & development 2013) 3 4 54

Products for H2BC21 Gene

  • Signalway ELISA kits for H2BC21
  • Signalway Proteins for H2BC21

Sources for H2BC21 Gene