Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in ... See more...

Aliases for H2BC20P Gene

Aliases for H2BC20P Gene

  • H2B Clustered Histone 20, Pseudogene 2 3 5
  • H2B/T 2 3 4
  • Histone Cluster 2 H2B Family Member C (Pseudogene) 2 3
  • Histone Cluster 2, H2bc (Pseudogene) 2 3
  • Histone 2, H2bc 2 3
  • HIST2H2BC 3 4
  • H2B-Clustered Histone 20 Pseudogene 4
  • Putative Histone H2B Type 2-C 4
  • Histone Cluster 2, H2bc 2
  • Histone H2B/S 3
  • Histone H2B.T 4
  • HIST2H2BD 3
  • H2BC20P 5

External Ids for H2BC20P Gene

Previous HGNC Symbols for H2BC20P Gene

  • HIST2H2BC

Previous GeneCards Identifiers for H2BC20P Gene

  • GC01M149872
  • GC01M149916

Summaries for H2BC20P Gene

Entrez Gene Summary for H2BC20P Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for H2BC20P Gene

H2BC20P (H2B Clustered Histone 20, Pseudogene) is a Pseudogene.

UniProtKB/Swiss-Prot Summary for H2BC20P Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Additional gene information for H2BC20P Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC20P Gene

Genomics for H2BC20P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for H2BC20P Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H2BC20P on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for H2BC20P Gene

Genomic Locations for H2BC20P Gene
chr1:149,844,498-149,850,937
(GRCh38/hg38)
Size:
6,440 bases
Orientation:
Minus strand
chr1:149,816,065-149,820,591
(GRCh37/hg19)
Size:
4,527 bases
Orientation:
Minus strand

Genomic View for H2BC20P Gene

Genes around H2BC20P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BC20P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BC20P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BC20P Gene

Proteins for H2BC20P Gene

  • Protein details for H2BC20P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DN03-H2B2C_HUMAN
    Recommended name:
    Putative histone H2B type 2-C
    Protein Accession:
    Q6DN03
    Secondary Accessions:
    • B7Z677

    Protein attributes for H2BC20P Gene

    Size:
    193 amino acids
    Molecular mass:
    21472 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Miscellaneous:
    • The mouse orthologous protein seems not to exist.

neXtProt entry for H2BC20P Gene

Post-translational modifications for H2BC20P Gene

  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for H2BC20P Gene

Domains & Families for H2BC20P Gene

Gene Families for H2BC20P Gene

HGNC:

Protein Domains for H2BC20P Gene

Suggested Antigen Peptide Sequences for H2BC20P Gene

GenScript: Design optimal peptide antigens:
  • Histone H2B.t (H2B2C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6DN03

UniProtKB/Swiss-Prot:

H2B2C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BC20P: view

Function for H2BC20P Gene

Molecular function for H2BC20P Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for H2BC20P Gene

Phenotypes for H2BC20P Gene

genes like me logo Genes that share phenotypes with H2BC20P: view

Animal Model Products

CRISPR Products

miRNA for H2BC20P Gene

miRTarBase miRNAs that target H2BC20P

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2BC20P Gene

Localization for H2BC20P Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BC20P Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for H2BC20P Gene

Pathways & Interactions for H2BC20P Gene

PathCards logo

SuperPathways for H2BC20P Gene

No Data Available

Interacting Proteins for H2BC20P Gene

Selected Interacting proteins: Q6DN03-H2B2C_HUMAN for H2BC20P Gene via IID

Symbol External ID(s) Details
JUN
MCM5

Gene Ontology (GO) - Biological Process for H2BC20P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for H2BC20P Gene

Drugs & Compounds for H2BC20P Gene

No Compound Related Data Available

Transcripts for H2BC20P Gene

mRNA/cDNA for H2BC20P Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BC20P Gene

No ASD Table

Relevant External Links for H2BC20P Gene

GeneLoc Exon Structure for
H2BC20P

Expression for H2BC20P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2BC20P

SOURCE GeneReport for Unigene cluster for H2BC20P Gene:

Hs.666643
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC20P Gene

Orthologs for H2BC20P Gene

Evolution for H2BC20P Gene

ENSEMBL:
Gene Tree for H2BC20P (if available)
TreeFam:
Gene Tree for H2BC20P (if available)

No data available for Orthologs for H2BC20P Gene

Paralogs for H2BC20P Gene

No data available for Paralogs for H2BC20P Gene

Variants for H2BC20P Gene

Structural Variations from Database of Genomic Variants (DGV) for H2BC20P Gene

Variant ID Type Subtype PubMed ID
esv1007634 OTHER inversion 20482838
nsv46 OTHER inversion 15895083
nsv469694 CNV loss 16826518
nsv499132 OTHER inversion 21111241
nsv7182 OTHER inversion 18451855
nsv831525 CNV gain 17160897
nsv946381 CNV duplication 23825009

Additional Variant Information for H2BC20P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BC20P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for H2BC20P Gene

Disorders for H2BC20P Gene

Additional Disease Information for H2BC20P

No disorders were found for H2BC20P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H2BC20P Gene

Publications for H2BC20P Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad CD … Stein GS (Gene 2004) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
  3. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F … Kasprzak KS (Molecular and cellular biochemistry 2005) 3 4
  4. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung WL … Allis CD (Cell 2003) 3 4
  5. Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. (PMID: 31542297) Bao X … Li XD (Molecular cell 2019) 4

Products for H2BC20P Gene

Sources for H2BC20P Gene