Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in ... See more...

Aliases for H2BC20P Gene

Aliases for H2BC20P Gene

  • H2B Clustered Histone 20, Pseudogene 2 3
  • Histone Cluster 2 H2B Family Member C (Pseudogene) 2 3 5
  • Histone Cluster 2, H2bc (Pseudogene) 2 3
  • Histone 2, H2bc 2 3
  • HIST2H2BC 3 5
  • Histone Cluster 2, H2bc 2
  • Histone H2B/S 3
  • HIST2H2BD 3
  • H2B/T 3

External Ids for H2BC20P Gene

Previous HGNC Symbols for H2BC20P Gene

  • HIST2H2BC

Summaries for H2BC20P Gene

Entrez Gene Summary for H2BC20P Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for H2BC20P Gene

H2BC20P (H2B Clustered Histone 20, Pseudogene) is a Pseudogene.

Additional gene information for H2BC20P Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC20P Gene

Genomics for H2BC20P Gene

GeneHancer (GH) Regulatory Elements for H2BC20P Gene

Promoters and enhancers for H2BC20P Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H2BC20P on UCSC Golden Path with GeneCards custom track

Genomic Locations for H2BC20P Gene

Genomic Locations for H2BC20P Gene
chr1:149,844,498-149,850,937
(GRCh38/hg38)
Size:
6,440 bases
Orientation:
Minus strand
chr1:149,816,065-149,820,591
(GRCh37/hg19)
Size:
4,527 bases
Orientation:
Minus strand

Genomic View for H2BC20P Gene

Genes around H2BC20P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BC20P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BC20P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BC20P Gene

Proteins for H2BC20P Gene

Post-translational modifications for H2BC20P Gene

No Post-translational modifications

No data available for DME Specific Peptides for H2BC20P Gene

Domains & Families for H2BC20P Gene

Gene Families for H2BC20P Gene

HGNC:

Suggested Antigen Peptide Sequences for H2BC20P Gene

GenScript: Design optimal peptide antigens:
  • Histone H2B.t (H2B2C_HUMAN)
genes like me logo Genes that share domains with H2BC20P: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for H2BC20P Gene

Function for H2BC20P Gene

Phenotypes From GWAS Catalog for H2BC20P Gene

Phenotypes for H2BC20P Gene

genes like me logo Genes that share phenotypes with H2BC20P: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BC20P Gene

Localization for H2BC20P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for H2BC20P Gene

Pathways & Interactions for H2BC20P Gene

PathCards logo

SuperPathways for H2BC20P Gene

No Data Available

Gene Ontology (GO) - Biological Process for H2BC20P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for H2BC20P Gene

Drugs & Compounds for H2BC20P Gene

No Compound Related Data Available

Transcripts for H2BC20P Gene

mRNA/cDNA for H2BC20P Gene

(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BC20P Gene

No ASD Table

Relevant External Links for H2BC20P Gene

GeneLoc Exon Structure for
H2BC20P
ECgene alternative splicing isoforms for
H2BC20P

Expression for H2BC20P Gene

NURSA nuclear receptor signaling pathways regulating expression of H2BC20P Gene:

H2BC20P

SOURCE GeneReport for Unigene cluster for H2BC20P Gene:

Hs.666643
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC20P Gene

Orthologs for H2BC20P Gene

Evolution for H2BC20P Gene

ENSEMBL:
Gene Tree for H2BC20P (if available)
TreeFam:
Gene Tree for H2BC20P (if available)

No data available for Orthologs for H2BC20P Gene

Paralogs for H2BC20P Gene

No data available for Paralogs for H2BC20P Gene

Variants for H2BC20P Gene

Sequence variations from dbSNP and Humsavar for H2BC20P Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1009565784 -- 149,849,706(-) T/G downstream_transcript_variant
rs1013070338 -- 149,850,237(-) T/C non_coding_transcript_variant
rs1013085481 -- 149,850,002(-) T/C downstream_transcript_variant
rs1015153667 -- 149,849,708(-) G/C downstream_transcript_variant
rs1024496342 -- 149,850,255(-) C/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for H2BC20P Gene

Variant ID Type Subtype PubMed ID
esv1007634 OTHER inversion 20482838
nsv46 OTHER inversion 15895083
nsv469694 CNV loss 16826518
nsv499132 OTHER inversion 21111241
nsv7182 OTHER inversion 18451855
nsv831525 CNV gain 17160897
nsv946381 CNV duplication 23825009

Additional Variant Information for H2BC20P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BC20P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for H2BC20P Gene

Disorders for H2BC20P Gene

No disorders were found for H2BC20P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for H2BC20P Gene

Publications for H2BC20P Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad CD … Stein GS (Gene 2004) 2 3 56
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 56
  3. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. (PMID: 27634302) Oliviero G … Cagney G (Molecular & cellular proteomics : MCP 2016) 3 56
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 56
  5. Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line. (PMID: 20194426) González-Romero R … Eirín-López JM (Molecular biology and evolution 2010) 3 56

Products for H2BC20P Gene

Sources for H2BC20P Gene