Aliases for H2BC18 Gene
External Ids for H2BC18 Gene
Previous HGNC Symbols for H2BC18 Gene
Previous GeneCards Identifiers for H2BC18 Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2BC18 Gene
H2BC18 (H2B Clustered Histone 18) is a Protein Coding gene. Diseases associated with H2BC18 include Fetal Akinesia Deformation Sequence 1. Among its related pathways are Chromatin organization and Deubiquitination. An important paralog of this gene is H2BC9.
UniProtKB/Swiss-Prot Summary for H2BC18 Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.