Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H2BC15 Gene
Aliases for H2BC15 Gene
External Ids for H2BC15 Gene
- HGNC: 4749
- NCBI Entrez Gene: 8341
- Ensembl: ENSG00000233822
- OMIM®: 602801
- UniProtKB/Swiss-Prot: Q99877
Previous HGNC Symbols for H2BC15 Gene
- H2BFD
- HIST1H2BN
Previous GeneCards Identifiers for H2BC15 Gene
- GC06P027922
- GC06P028140
- GC06P028804
- GC06P029412
Summaries for H2BC15 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2BC15 Gene
H2BC15 (H2B Clustered Histone 15) is a Protein Coding gene. Diseases associated with H2BC15 include Diamond-Blackfan Anemia 1. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H2BC4.
UniProtKB/Swiss-Prot Summary for H2BC15 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H2BC15 Gene
- HGNC (4749)
- NCBI Entrez Gene (8341)
- Ensembl (ENSG00000233822)
- OMIM® (602801)
- UniProtKB/Swiss-Prot (Q99877)
- Open Targets Platform(ENSG00000233822)
- Alliance of Genome Resources
- Search for H2BC15 at DataMed
- Search for H2BC15 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC15 Gene
Genomics for H2BC15 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H2BC15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H2BC15 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2BC15
Genomic Locations for H2BC15 Gene
Latest Assembly
- chr6:27,837,760-27,855,709
- (GRCh38/hg38)
- Size:
- 17,950 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:27,806,347-27,806,888
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 542 bases
- Orientation:
- Plus strand
Genomic View for H2BC15 Gene
Genes around H2BC15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
H2BC15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H2BC15 Gene
Proteins for H2BC15 Gene
-
Protein details for H2BC15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99877-H2B1N_HUMAN
- Recommended name:
- Histone H2B type 1-N
- Protein Accession:
- Q99877
- B2R5L4
- Q494S8
- Q96FB7
Protein attributes for H2BC15 Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13922 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H2BC15 Gene
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
-
Glycosylation at Ser113
- NX_Q99877 (NX_Q99877-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H2BC15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Invitrogen Antibodies for H2BC15 (AFLGC-H2BC15)
- antibodies-online: Show 8 available Histone H2B Type 1-N Antibodies ranked by validation data
Protein products for research
-
OriGene Purified Proteins for H2BC15
- Search Origene for MassSpec and Protein Over-expression Lysates for H2BC15
- Origene Custom Protein Services for H2BC15
Assay products for research
No data available for DME Specific Peptides for H2BC15 Gene
Domains & Families for H2BC15 Gene
Gene Families for H2BC15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for H2BC15 Gene
- InterPro:
Suggested Antigen Peptide Sequences for H2BC15 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone H2B.d (H2B1N_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99877- Family:
-
- Belongs to the histone H2B family.
Function for H2BC15 Gene
Molecular function for H2BC15 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H2BC15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA,NAS | 9439656 |
| GO:0005515 | protein binding | IPI | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H2BC15 Gene
- GenomeRNAi human phenotypes for H2BC15:
-
- no effect
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased NF-kappaB reporter expression
- Increased IL-8 secretion
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H2BC15 - Starting at $85 >
- * H2BC15 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H2BC15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC15
miRNA for H2BC15 Gene
- miRTarBase miRNAs that target H2BC15
-
- hsa-miR-6788-5p (MIRT677900)
- hsa-miR-30c-2-3p (MIRT677901)
- hsa-miR-30c-1-3p (MIRT677902)
- hsa-miR-7703 (MIRT677903)
- hsa-miR-6720-5p (MIRT677904)
- hsa-miR-6512-3p (MIRT677905)
- hsa-miR-8085 (MIRT677906)
- hsa-miR-6731-5p (MIRT677907)
- hsa-miR-6878-5p (MIRT677908)
- hsa-miR-139-3p (MIRT677909)
- hsa-miR-661 (MIRT677910)
- hsa-miR-4252 (MIRT677911)
- hsa-miR-3192-5p (MIRT677912)
- hsa-miR-4793-3p (MIRT677913)
- hsa-miR-766-3p (MIRT677914)
- hsa-miR-1292-3p (MIRT677915)
- hsa-miR-6849-3p (MIRT677916)
- hsa-miR-1273g-3p (MIRT677917)
- hsa-miR-508-5p (MIRT677918)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2BC15
- Browse OriGene Inhibitory RNA Products For H2BC15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC15
Clone products for research
- Applied Biological Materials (abm): Clones for H2BC15 - Starting at $45 >
- * H2BC15 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H2BC15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC15
Cell Lines for research
-
Horizon Cell Lines for H2BC15
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2BC15 Gene
Localization for H2BC15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H2BC15 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA,NAS | 9439656 |
| GO:0005634 | nucleus | IEA,IDA | 16319397 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for H2BC15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for H2BC15 Gene
1 BioSystems pathway for H2BC15 Gene
68 Reactome pathways for H2BC15 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
4 KEGG pathways for H2BC15 Gene
1 GeneGo (Thomson Reuters) pathway for H2BC15 Gene
- Signal transduction Activin A signaling regulation
Interacting Proteins for H2BC15 Gene
GPS-Prot Interaction Network for H2BC15
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IBA,NAS | 9439656 |
| GO:0016567 | protein ubiquitination | TAS | -- |
No data available for SIGNOR curated interactions for H2BC15 Gene
Transcripts for H2BC15 Gene
mRNA/cDNA for H2BC15 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000449538 715 nts (view in UCSC)
- ENST00000606613 4137 nts (view in UCSC)
- ENST00000612898 1723 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H2BC15 - Starting at $85 >
- * H2BC15 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H2BC15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC15
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2BC15
- Browse OriGene Inhibitory RNA Products For H2BC15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC15
Clone products for research
- Applied Biological Materials (abm): Clones for H2BC15 - Starting at $45 >
- * H2BC15 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H2BC15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC15
Relevant External Links for H2BC15 Gene
- GeneLoc Exon Structure for
- H2BC15
Expression for H2BC15 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2BC15
SOURCE GeneReport for Unigene cluster for H2BC15 Gene:
Hs.673851Evidence on tissue expression from TISSUES for H2BC15 Gene
- Eye(4.2)
- Blood(2.3)
- Intestine(2.3)
- Spleen(2.2)
- Liver(2.2)
- Bone marrow(2.2)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for H2BC15
-
OriGene qPCR primer pairs and template standards for H2BC15
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC15 Gene
Orthologs for H2BC15 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2BN 30 |
|
OneToOne | |
| LOC462508 29 |
|
||||
| Cow (Bos Taurus) |
Mammalia | H2B 30 |
|
OneToOne | |
| LOC787269 29 |
|
||||
| Dog (Canis familiaris) |
Mammalia | LOC478743 29 |
|
||
| -- 30 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Hist1h2bm 29 |
|
||
| H2bc14 16 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Hist1h2bd 29 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.12831 29 |
|
- Species where no ortholog for H2BC15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for H2BC15 Gene
- ENSEMBL:
- Gene Tree for H2BC15 (if available)
- TreeFam:
- Gene Tree for H2BC15 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H2BC15: view image
- Alliance of Genome Resources:
- Additional Orthologs for H2BC15
Paralogs for H2BC15 Gene
Variants for H2BC15 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3608441 | CNV | gain | 21293372 |
| nsv969367 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H2BC15 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2BC15 Gene
Disorders for H2BC15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diamond-blackfan anemia 1 |
|
|
Search H2BC15 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for H2BC15
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for H2BC15 Gene
Publications for H2BC15 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4
- Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck HC … Jensen ON (Molecular & cellular proteomics : MCP 2006) 3 4
- Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. (PMID: 16319397) Bonenfant D … van Oostrum J (Molecular & cellular proteomics : MCP 2006) 3 4
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R … Reinberg D (Cell 2006) 3 4
ExternalLinks
Products for H2BC15 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for H2BC15
- Search Origene for MassSpec and Protein Over-expression Lysates for H2BC15
- Origene Custom Protein Services for H2BC15
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2BC15
- Browse OriGene Inhibitory RNA Products For H2BC15
- OriGene qPCR primer pairs for H2BC15
- OriGene qPCR primer pairs and template standards for H2BC15
- OriGene CRISPR knockouts for H2BC15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For H2BC15
- Sino Biological Human cDNA Clone for H2BC15
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals proteins and lysates for H2BC15
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for H2BC15 (AFLGC-H2BC15)
- VectorBuilder Custom and pre-made DNA vectors for H2BC15 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H2BC15 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for H2BC15 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for H2BC15 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H2BC15
- antibodies-online: Show 8 available Histone H2B Type 1-N Antibodies ranked by validation data
- antibodies-online: Search results for available Histone H2B Type 1-N related products ranked by validation data
- antibodies-online: Search results for available Histone H2B Type 1-N related products ranked by validation data
- Horizon Cell Lines for H2BC15
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC15
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H2BC15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC15
Sources for H2BC15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources