Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H2BC14 Gene
Aliases for H2BC14 Gene
External Ids for H2BC14 Gene
- HGNC: 4750
- Entrez Gene: 8342
- Ensembl: ENSG00000273703
- OMIM: 602802
- UniProtKB: Q99879
Previous HGNC Symbols for H2BC14 Gene
- H2BFE
- HIST1H2BM
Summaries for H2BC14 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2BC14 Gene
H2BC14 (H2B Clustered Histone 14) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H2BC7.
UniProtKB/Swiss-Prot Summary for H2BC14 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H2BC14 Gene
- Monarch Initiative
- Search for H2BC14 at DataMed
- Search for H2BC14 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC14 Gene
Genomics for H2BC14 Gene
GeneHancer (GH) Regulatory Elements for H2BC14 Gene
Promoters and enhancers for H2BC14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H2BC14 on UCSC Golden Path with GeneCards custom track
Genomic Locations for H2BC14 Gene
Genomic Locations for H2BC14 Gene
- chr6:27,815,044-27,815,489
- (GRCh38/hg38)
- Size:
- 446 bases
- Orientation:
- Plus strand
- chr6:27,782,822-27,783,267
- (GRCh37/hg19)
- Size:
- 446 bases
- Orientation:
- Plus strand
Genomic View for H2BC14 Gene
Genes around H2BC14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
H2BC14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H2BC14 Gene
Proteins for H2BC14 Gene
-
Protein details for H2BC14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99879-H2B1M_HUMAN
- Recommended name:
- Histone H2B type 1-M
- Protein Accession:
- Q99879
- Q6NWQ3
Protein attributes for H2BC14 Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13989 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H2BC14 Gene
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- ADP-ribosylated on Ser-7 in response to DNA damage.
-
Glycosylation at Ser113
- NX_Q99879 (NX_Q99879-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H2BC14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for H2BC14 (AFLGC-HIST1H2BM)
- antibodies-online: Show 5 available Histone H2B Type 1-M Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for H2BC14
- Search Origene for MassSpec and Protein Over-expression Lysates for H2BC14
- Origene Custom Protein Services for H2BC14
- Novus Biologicals lysates for H2BC14
No data available for DME Specific Peptides for H2BC14 Gene
Domains & Families for H2BC14 Gene
Gene Families for H2BC14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for H2BC14 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for H2BC14 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone H2B.e (H2B1M_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99879- Family:
-
- Belongs to the histone H2B family.
Function for H2BC14 Gene
Molecular function for H2BC14 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H2BC14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS,IBA | 9439656 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H2BC14 Gene
- GenomeRNAi human phenotypes for H2BC14:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H2BC14 - Select products 50% OFF >
- * H2BC14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * H2BC14 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for H2BC14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC14
- genomics-online: gRNA clones - Search results for available Histone H2B Type 1-M gene related products
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for H2BC14
- Browse OriGene Inhibitory RNA Products For H2BC14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14
- genomics-online: shRNA clones - Search results for available Histone H2B Type 1-M gene related products
Clone Products
- Applied Biological Materials (abm): Clones for H2BC14 - Select products 50% OFF >
- * H2BC14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * H2BC14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for H2BC14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC14
- genomics-online: cdna clones - Search results for available Histone H2B Type 1-M gene related products
- orf clones - Search results for available Histone H2B Type 1-M gene related products
Cell Line Products
-
Horizon Cell Lines for H2BC14
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BC14 Gene
Localization for H2BC14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H2BC14 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | NAS | 9439656 |
| GO:0005634 | nucleus | IEA,IDA | 16319397 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for H2BC14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for H2BC14 Gene
68 Reactome pathways for H2BC14 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for H2BC14 Gene
1 GeneGo (Thomson Reuters) pathway for H2BC14 Gene
Interacting Proteins for H2BC14 Gene
GPS-Prot Interaction Network for H2BC14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IBA,NAS | 9439656 |
| GO:0016567 | protein ubiquitination | TAS | -- |
No data available for SIGNOR curated interactions for H2BC14 Gene
Transcripts for H2BC14 Gene
mRNA/cDNA for H2BC14 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (20) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000621112 381 bps (ENST00000621112.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H2BC14 - Select products 50% OFF >
- * H2BC14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * H2BC14 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for H2BC14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC14
- genomics-online: gRNA clones - Search results for available Histone H2B Type 1-M gene related products
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for H2BC14
- Browse OriGene Inhibitory RNA Products For H2BC14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14
- genomics-online: shRNA clones - Search results for available Histone H2B Type 1-M gene related products
Clone Products
- Applied Biological Materials (abm): Clones for H2BC14 - Select products 50% OFF >
- * H2BC14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * H2BC14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for H2BC14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC14
- genomics-online: cdna clones - Search results for available Histone H2B Type 1-M gene related products
- orf clones - Search results for available Histone H2B Type 1-M gene related products
Expression for H2BC14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
NURSA nuclear receptor signaling pathways regulating expression of H2BC14 Gene:
H2BC14SOURCE GeneReport for Unigene cluster for H2BC14 Gene:
Hs.182432Evidence on tissue expression from TISSUES for H2BC14 Gene
- Nervous system(4.3)
- Intestine(2.7)
Primer Products
-
OriGene qPCR primer pairs for H2BC14
- genomics-online: primer clones - Search results for available Histone H2B Type 1-M gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC14 Gene
Orthologs for H2BC14 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h2bn 32 |
|
||
| H2bc15 17 |
|
||||
| dog (Canis familiaris) |
Mammalia | LOC100683643 32 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC748505 32 |
|
||
| cow (Bos Taurus) |
Mammalia | HIST1H2BB 32 |
|
- Species where no ortholog for H2BC14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for H2BC14 Gene
- ENSEMBL:
- Gene Tree for H2BC14 (if available)
- TreeFam:
- Gene Tree for H2BC14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H2BC14: view image
Paralogs for H2BC14 Gene
Paralogs for H2BC14 Gene
Pseudogenes.org Pseudogenes for H2BC14 Gene
Variants for H2BC14 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036205 | A colorectal cancer sample | p.His110Tyr | |||
| rs1003588463 | -- | 27,813,983(+) | C/T | upstream_transcript_variant | |
| rs1004068522 | -- | 27,814,159(+) | C/G | upstream_transcript_variant | |
| rs1004900989 | -- | 27,815,510(+) | G/A | downstream_transcript_variant | |
| rs1005229686 | -- | 27,814,266(+) | G/A | upstream_transcript_variant |
Residual Variation Intolerance Score:
43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H2BC14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H2BC14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2BC14 Gene
Disorders for H2BC14 Gene
No disorders were found for H2BC14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for H2BC14 Gene
Publications for H2BC14 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 56
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 56
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R … Reinberg D (Cell 2006) 3 4 56
- Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N … Pesavento JJ (Journal of proteome research 2006) 3 4 56
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PMID: 16307923) Zhu B … Reinberg D (Molecular cell 2005) 3 4 56
ExternalLinks
Products for H2BC14 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for H2BC14
- Search Origene for MassSpec and Protein Over-expression Lysates for H2BC14
- Origene Custom Protein Services for H2BC14
- Origene sirna, shrna, and RNAi products in human, mouse, rat for H2BC14
- Browse OriGene Inhibitory RNA Products For H2BC14
- OriGene qPCR primer pairs for H2BC14
- OriGene CRISPR knockouts for H2BC14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For H2BC14
- Sino Biological Human cDNA Clone for H2BC14
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals lysates for H2BC14
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for H2BC14 (AFLGC-HIST1H2BM)
- antibodies-online: Show 5 available Histone H2B Type 1-M Antibodies ranked by validation data
- antibodies-online: Search results for available Histone H2B Type 1-M related products ranked by validation data
- antibodies-online: Search results for available Histone H2B Type 1-M related products ranked by validation data
- Horizon Cell Lines for H2BC14
- genomics-online: cdna clones - Search results for available Histone H2B Type 1-M gene related products
- orf clones - Search results for available Histone H2B Type 1-M gene related products
- genomics-online: gRNA clones - Search results for available Histone H2B Type 1-M gene related products
- genomics-online: primer clones - Search results for available Histone H2B Type 1-M gene related products
- genomics-online: shRNA clones - Search results for available Histone H2B Type 1-M gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2BC14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2BC14
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H2BC14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14
Sources for H2BC14 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource