H2BC14 Gene (Protein Coding)

H2B Clustered Histone 14

GC06P051796
GIFtS:
27
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...

Aliases for H2BC14 Gene

Aliases for H2BC14 Gene

  • H2B Clustered Histone 14 2 3 5
  • H2B/E 2 3 4
  • Histone Cluster 1 H2B Family Member M 2 3
  • H2B Histone Family, Member E 2 3
  • Histone Cluster 1, H2bm 2 3
  • Histone H2B Type 1-M 3 4
  • Histone 1, H2bm 2 3
  • Histone H2B.E 3 4
  • DJ160A22.3 2 3
  • HIST1H2BM 3 4
  • H2BFE 3 4
  • H2BC14 5

External Ids for H2BC14 Gene

Previous HGNC Symbols for H2BC14 Gene

  • H2BFE
  • HIST1H2BM

Previous GeneCards Identifiers for H2BC14 Gene

  • GC06P027906
  • GC06P028120
  • GC06P028800
  • GC06P029399

Summaries for H2BC14 Gene

Entrez Gene Summary for H2BC14 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for H2BC14 Gene

H2BC14 (H2B Clustered Histone 14) is a Protein Coding gene. Diseases associated with H2BC14 include Tonsil Squamous Cell Carcinoma and Luminal Breast Carcinoma A. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H2BC3.

UniProtKB/Swiss-Prot Summary for H2BC14 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for H2BC14 Gene

Additional gene information for H2BC14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC14 Gene

Genomics for H2BC14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for H2BC14 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J027805 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 253.5 -1.8 -1829 14.9 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC IKZF1 ZNF600 SSRP1 JUND H2BC14 H2AC14 piR-45268-005 piR-54008 piR-57462 ZSCAN9 ZKSCAN4 ZKSCAN8 ZKSCAN3 ZSCAN12
GH06J027834 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +22.3 22319 6.5 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 JUND ZNF580 ZNF592 ATF2 H2BC15 H2AC15 HSALNG0048914 ZSCAN12 ZKSCAN3 ZSCAN9 ZKSCAN8 ZKSCAN4 ZSCAN26 PGBD1
GH06J027887 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.4 +78.5 78459 11.9 BCLAF1 SP1 MYC ZNF600 NCOR1 IKZF1 ZNF654 SSRP1 JUND ZNF592 H2BC17 H2AC17 H3C12 HSALNG0048927 piR-38252 piR-39028 piR-51953-002 piR-56252 ZKSCAN8 ZSCAN9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H2BC14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2BC14

Genomic Locations for H2BC14 Gene

Latest Assembly
chr6:27,815,022-27,815,489
(GRCh38/hg38)
Size:
468 bases
Orientation:
Plus strand

Previous Assembly
chr6:27,782,800-27,783,267
(GRCh37/hg19 by Entrez Gene)
Size:
468 bases
Orientation:
Plus strand

Genomic View for H2BC14 Gene

Genes around H2BC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BC14 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for H2BC14 Gene

Proteins for H2BC14 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for H2BC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99879-H2B1M_HUMAN
    Recommended name:
    Histone H2B type 1-M
    Protein Accession:
    Q99879
    Secondary Accessions:
    • Q6NWQ3

    Protein attributes for H2BC14 Gene

    Size:
    126 amino acids
    Molecular mass:
    13989 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for H2BC14 Gene

Post-translational modifications for H2BC14 Gene

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • ADP-ribosylated on Ser-7 in response to DNA damage.
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for H2BC14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BC14 Gene

Domains & Families for H2BC14 Gene

Gene Families for H2BC14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H2BC14 Gene

InterPro:

Suggested Antigen Peptide Sequences for H2BC14 Gene

GenScript: Design optimal peptide antigens:
  • Histone H2B.e (H2B1M_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99879

UniProtKB/Swiss-Prot:

H2B1M_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BC14: view

Function for H2BC14 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for H2BC14 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for H2BC14 Gene

Gene Ontology (GO) - Molecular Function for H2BC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,NAS 9439656
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BC14: view
genes like me logo Genes that share phenotypes with H2BC14: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BC14 Gene

Localization for H2BC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BC14 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2BC14 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for H2BC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 9439656
GO:0005634 nucleus IEA,IDA 16319397
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with H2BC14: view

Pathways & Interactions for H2BC14 Gene

PathCards logo

SuperPathways for H2BC14 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
DNA methylation
.88
RNA Polymerase I Promoter Opening
.88
B-WICH complex positively regulates rRNA expression
.86
Positive epigenetic regulation of rRNA expression
.86
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
.86
SIRT1 negatively regulates rRNA Expression
.84
NoRC negatively regulates rRNA expression
.83
RNA Polymerase I Chain Elongation
.83
PRC2 methylates histones and DNA
.83
RNA Polymerase I Transcription
.81
Negative epigenetic regulation of rRNA expression
.81
RNA Polymerase I Promoter Clearance
.81
Condensation of Prophase Chromosomes
.78
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
.76
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
.75
Epigenetic regulation of gene expression
.73
RHO GTPases activate PKNs
.72
Formation of the beta-catenin-TCF transactivating complex
.64
HDACs deacetylate histones
.60
Amyloid fiber formation
.55
Activation of anterior HOX genes in hindbrain development during early embryogenesis
.50
Activation of HOX genes during differentiation
.50
Systemic lupus erythematosus
.43
Neutrophil extracellular trap formation
.38
Alcoholism
.35
2 DNA Double-Strand Break Repair
DNA Double-Strand Break Repair
.83
Homology Directed Repair
.83
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
.79
Processing of DNA double-strand break ends
.74
G2/M DNA damage checkpoint
.74
DNA Repair
.53
3 Cellular Senescence (REACTOME)
Cellular Senescence
.64
Oxidative Stress Induced Senescence
.64
Senescence-Associated Secretory Phenotype (SASP)
.56
Cellular responses to stress
.44
4 Chromosome Maintenance
Chromosome Maintenance
.75
Telomere Maintenance
.75
Deposition of new CENPA-containing nucleosomes at the centromere
.66
Nucleosome assembly
.66
5 Cell Cycle, Mitotic
Cell Cycle
.83
Cell Cycle, Mitotic
.83
M Phase
.60
genes like me logo Genes that share pathways with H2BC14: view

Gene Ontology (GO) - Biological Process for H2BC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA,NAS 9439656
GO:0016567 protein ubiquitination TAS --
genes like me logo Genes that share ontologies with H2BC14: view

No data available for SIGNOR curated interactions for H2BC14 Gene

Drugs & Compounds for H2BC14 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for H2BC14 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for H2BC14 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14

Alternative Splicing Database (ASD) splice patterns (SP) for H2BC14 Gene

No ASD Table

Relevant External Links for H2BC14 Gene

GeneLoc Exon Structure for
H2BC14

Expression for H2BC14 Gene

Products:

  1. Primer products for research

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2BC14

SOURCE GeneReport for Unigene cluster for H2BC14 Gene:

Hs.182432

Evidence on tissue expression from TISSUES for H2BC14 Gene

  • Nervous system(4.4)
  • Intestine(2.7)
genes like me logo Genes that share expression patterns with H2BC14: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC14 Gene

Orthologs for H2BC14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for H2BC14 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
 Mammalia Hist1h2bn 29
  • 88.36 (n)
H2bc15 16
Dog
(Canis familiaris)
 Mammalia LOC100683643 29
  • 87.6 (n)
Chimpanzee
(Pan troglodytes)
 Mammalia LOC748505 29
  • 85.71 (n)
Cow
(Bos Taurus)
 Mammalia HIST1H2BB 29
  • 84.39 (n)
Species where no ortholog for H2BC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for H2BC14 Gene

ENSEMBL:
Gene Tree for H2BC14 (if available)
TreeFam:
Gene Tree for H2BC14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H2BC14: view image
Alliance of Genome Resources:
Additional Orthologs for H2BC14

Paralogs for H2BC14 Gene

Variants for H2BC14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2BC14 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
VAR_036205 A colorectal cancer sample p.His110Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for H2BC14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for H2BC14 Gene

Variant ID Type Subtype PubMed ID
nsv1017057 CNV gain 25217958
nsv830618 CNV gain 17160897
nsv970094 CNV duplication 23825009

Variation tolerance for H2BC14 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H2BC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BC14
Leiden Open Variation Database (LOVD)
H2BC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2BC14 Gene

Disorders for H2BC14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for H2BC14 Gene - From: COP

Disorder Aliases PubMed IDs
tonsil squamous cell carcinoma
  • tonsillar squamous cell carcinoma
luminal breast carcinoma a
  • breast tumor luminal
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for H2BC14

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with H2BC14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H2BC14 Gene

Publications for H2BC14 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4
  3. Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N … Pesavento JJ (Journal of proteome research 2006) 3 4
  4. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R … Reinberg D (Cell 2006) 3 4
  5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PMID: 16307923) Zhu B … Reinberg D (Molecular cell 2005) 3 4

ExternalLinks

View latest publications for H2BC14 gene in Mastermind

Products for H2BC14 Gene

Sources for H2BC14 Gene