Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...

Aliases for H2BC14 Gene

Aliases for H2BC14 Gene

  • H2B Clustered Histone 14 2 3
  • Histone Cluster 1 H2B Family Member M 2 3 5
  • H2B Histone Family, Member E 2 3
  • Histone Cluster 1, H2bm 2 3
  • Histone H2B Type 1-M 3 4
  • Histone 1, H2bm 2 3
  • Histone H2B.E 3 4
  • HIST1H2BM 3 5
  • H2BFE 3 4
  • H2B/E 3 4
  • DJ160A22.3 3

External Ids for H2BC14 Gene

Previous HGNC Symbols for H2BC14 Gene

  • H2BFE
  • HIST1H2BM

Summaries for H2BC14 Gene

Entrez Gene Summary for H2BC14 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for H2BC14 Gene

H2BC14 (H2B Clustered Histone 14) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME). An important paralog of this gene is H2BC7.

UniProtKB/Swiss-Prot Summary for H2BC14 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for H2BC14 Gene

Additional gene information for H2BC14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC14 Gene

Genomics for H2BC14 Gene

GeneHancer (GH) Regulatory Elements for H2BC14 Gene

Promoters and enhancers for H2BC14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J027834 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +22.4 22397 6.7 PPP1R10 E2F8 ZNF785 ZBTB40 SP1 FOXA1 MLX SMARCE1 RBPJ POLR2A H2BC15 H2AC15 ZKSCAN8 ZKSCAN3 ZSCAN12 ZSCAN9 ZKSCAN4 GUSBP2 ZNF204P HNRNPA1P1
GH06J027887 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.4 +78.4 78437 11.9 GTF3C2 E2F8 ZNF24 SP1 ZBTB40 CTCF SREBF1 ZBTB6 MLX RBPJ H2AC17 H2BC17 H3C12 piR-39028 piR-38252 piR-56252 piR-51953-002 ZKSCAN8 ZKSCAN3 ZKSCAN4
GH06J027805 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.5 -2.9 -2929 12.7 PPP1R10 SIN3A ZNF24 SP1 CTCF SREBF1 ZBTB6 MLX SMARCE1 RBPJ Z46261-004 piR-57462 ZKSCAN8 ZKSCAN3 ZKSCAN4 ZSCAN9 ZNF603P ZSCAN26 ZSCAN12 ZNF192P1
GH06J027819 Enhancer 0.6 ENCODE 0.6 +4.8 4778 1.6 ZNF24 CTCF L3MBTL2 RAD21 MLLT1 TRIM22 ZNF316 PAX8 SMARCA5 SMC3 ZNF603P H2BC14 H4C11 RF00017-5385
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H2BC14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for H2BC14 Gene

Genomic Locations for H2BC14 Gene
chr6:27,815,044-27,815,489
(GRCh38/hg38)
Size:
446 bases
Orientation:
Plus strand
chr6:27,782,822-27,783,267
(GRCh37/hg19)
Size:
446 bases
Orientation:
Plus strand

Genomic View for H2BC14 Gene

Genes around H2BC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BC14 Gene

Proteins for H2BC14 Gene

  • Protein details for H2BC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99879-H2B1M_HUMAN
    Recommended name:
    Histone H2B type 1-M
    Protein Accession:
    Q99879
    Secondary Accessions:
    • Q6NWQ3

    Protein attributes for H2BC14 Gene

    Size:
    126 amino acids
    Molecular mass:
    13989 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for H2BC14 Gene

Post-translational modifications for H2BC14 Gene

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • ADP-ribosylated on Ser-7 in response to DNA damage.
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for H2BC14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BC14 Gene

Domains & Families for H2BC14 Gene

Gene Families for H2BC14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H2BC14 Gene

Suggested Antigen Peptide Sequences for H2BC14 Gene

GenScript: Design optimal peptide antigens:
  • Histone H2B.e (H2B1M_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99879

UniProtKB/Swiss-Prot:

H2B1M_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BC14: view

Function for H2BC14 Gene

Molecular function for H2BC14 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for H2BC14 Gene

Gene Ontology (GO) - Molecular Function for H2BC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS,IBA 9439656
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BC14: view
genes like me logo Genes that share phenotypes with H2BC14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BC14 Gene

Localization for H2BC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BC14 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2BC14 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for H2BC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 9439656
GO:0005634 nucleus IEA,IDA 16319397
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with H2BC14: view

Pathways & Interactions for H2BC14 Gene

PathCards logo

SuperPathways for H2BC14 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with H2BC14: view

Gene Ontology (GO) - Biological Process for H2BC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA,NAS 9439656
GO:0016567 protein ubiquitination TAS --
genes like me logo Genes that share ontologies with H2BC14: view

No data available for SIGNOR curated interactions for H2BC14 Gene

Drugs & Compounds for H2BC14 Gene

No Compound Related Data Available

Transcripts for H2BC14 Gene

mRNA/cDNA for H2BC14 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC14

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BC14 Gene

No ASD Table

Relevant External Links for H2BC14 Gene

GeneLoc Exon Structure for
H2BC14
ECgene alternative splicing isoforms for
H2BC14

Expression for H2BC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of H2BC14 Gene:

H2BC14

SOURCE GeneReport for Unigene cluster for H2BC14 Gene:

Hs.182432

Evidence on tissue expression from TISSUES for H2BC14 Gene

  • Nervous system(4.3)
  • Intestine(2.7)
genes like me logo Genes that share expression patterns with H2BC14: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC14 Gene

Orthologs for H2BC14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for H2BC14 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h2bn 32
  • 88.36 (n)
H2bc15 17
dog
(Canis familiaris)
Mammalia LOC100683643 32
  • 87.6 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC748505 32
  • 85.71 (n)
cow
(Bos Taurus)
Mammalia HIST1H2BB 32
  • 84.39 (n)
Species where no ortholog for H2BC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H2BC14 Gene

ENSEMBL:
Gene Tree for H2BC14 (if available)
TreeFam:
Gene Tree for H2BC14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H2BC14: view image

Paralogs for H2BC14 Gene

Variants for H2BC14 Gene

Sequence variations from dbSNP and Humsavar for H2BC14 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_036205 A colorectal cancer sample p.His110Tyr
rs1003588463 -- 27,813,983(+) C/T upstream_transcript_variant
rs1004068522 -- 27,814,159(+) C/G upstream_transcript_variant
rs1004900989 -- 27,815,510(+) G/A downstream_transcript_variant
rs1005229686 -- 27,814,266(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for H2BC14 Gene

Variant ID Type Subtype PubMed ID
nsv1017057 CNV gain 25217958
nsv830618 CNV gain 17160897
nsv970094 CNV duplication 23825009

Variation tolerance for H2BC14 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H2BC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2BC14 Gene

Disorders for H2BC14 Gene

No disorders were found for H2BC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for H2BC14 Gene

Publications for H2BC14 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 56
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 56
  3. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R … Reinberg D (Cell 2006) 3 4 56
  4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N … Pesavento JJ (Journal of proteome research 2006) 3 4 56
  5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PMID: 16307923) Zhu B … Reinberg D (Molecular cell 2005) 3 4 56

Products for H2BC14 Gene

Sources for H2BC14 Gene