Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
H2BC12 (H2B Clustered Histone 12) is a Protein Coding gene. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2BC7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0005615 | extracellular space | IDA | 12860195 |
GO:0005634 | nucleus | IEA,IDA | 16319397 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Cellular Senescence (REACTOME) | ||
4 | Chromosome Maintenance | ||
5 | Cell Cycle, Mitotic |
.83
|
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
GO:0006334 | nucleosome assembly | IBA | 21873635 |
GO:0016567 | protein ubiquitination | TAS | -- |
GO:0019731 | antibacterial humoral response | IDA | 12860195 |
GO:0031640 | killing of cells of other organism | IDA | 15019208 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | HIST1H2BK 31 |
|
OneToOne | |
LOC488303 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | HIST1H2BK 31 |
|
OneToOne | |
HIST1H2BM 30 |
|
||||
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2BK 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hist1h2bk 30 31 |
|
OneToOne | |
H2bc12 17 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Hist1h2bk 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780599 | Benign: not provided | 27,139,614(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1029124 | CNV | loss | 25217958 |
nsv970091 | CNV | duplication | 23825009 |
No disorders were found for H2BC12 Gene.