Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...

Aliases for H2BC10 Gene

Aliases for H2BC10 Gene

  • H2B Clustered Histone 10 2 3
  • Histone Cluster 1 H2B Family Member I 2 3 5
  • HIST1H2BI 3 4 5
  • H2B Histone Family, Member K 2 3
  • Histone Cluster 1, H2bi 2 3
  • Histone H2B.1 A 3 4
  • Histone 1, H2bi 2 3
  • Histone H2B.K 3 4
  • H2BFK 3 4
  • H2B/K 3 4
  • Histone H2B Type 1-C/E/F/G/I 3
  • Histone H2B.A 4
  • Histone H2B.G 4
  • Histone H2B.H 4
  • Histone H2B.L 4
  • HIST1H2BC 4
  • HIST1H2BE 4
  • HIST1H2BF 4
  • HIST1H2BG 4
  • H2BC4 3
  • H2BC6 3
  • H2BC7 3
  • H2BC8 3
  • H2B/A 4
  • H2B/G 4
  • H2B/H 4
  • H2B/L 4
  • H2BFA 4
  • H2BFG 4
  • H2BFH 4
  • H2BFL 4

External Ids for H2BC10 Gene

Previous HGNC Symbols for H2BC10 Gene

  • H2BFK
  • HIST1H2BI

Previous GeneCards Identifiers for H2BC10 Gene

  • GC06P027651

Summaries for H2BC10 Gene

Entrez Gene Summary for H2BC10 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for H2BC10 Gene

H2BC10 (H2B Clustered Histone 10) is a Protein Coding gene. Diseases associated with H2BC10 include Ehrlich Tumor Carcinoma. Among its related pathways are Metabolism of proteins and Signaling by Wnt. An important paralog of this gene is H2BC4.

UniProtKB/Swiss-Prot Summary for H2BC10 Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for H2BC10 Gene

Additional gene information for H2BC10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2BC10 Gene

Genomics for H2BC10 Gene

GeneHancer (GH) Regulatory Elements for H2BC10 Gene

Promoters and enhancers for H2BC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J026268 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.0 -1049 6.5 ZBTB40 ZNF217 TCF12 SIN3A SP1 FOS TEAD4 ZFX ZIC2 POLR2A ENSG00000218690 H2AC10P H2BC10 H3C8 lnc-HIST1H2BI-1 ABT1 ENSG00000272462 H4C8 BTN3A2 BTN2A3P
GH06J026275 Enhancer 0.5 dbSUPER 0.7 +3.8 3768 2.9 OSR2 ZKSCAN1 POLR2A GATA1 ZNF157 ZNF766 SCRT2 H4C8 H2BC10 LOC105374985
GH06J026282 Enhancer 0.7 CraniofacialAtlas dbSUPER 0.4 +9.6 9597 0.4 ADNP ZSCAN29 YY1 EGR1 PHF21A HDGF POLR2A HDAC1 H4C8 LOC105374985 H2BC10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H2BC10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2BC10

Genomic Locations for H2BC10 Gene

Genomic Locations for H2BC10 Gene
chr6:26,272,976-26,273,412
(GRCh38/hg38)
Size:
437 bases
Orientation:
Plus strand
chr6:26,273,144-26,273,640
(GRCh37/hg19)
Size:
497 bases
Orientation:
Plus strand

Genomic View for H2BC10 Gene

Genes around H2BC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BC10 Gene

Proteins for H2BC10 Gene

  • Protein details for H2BC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62807-H2B1C_HUMAN
    Recommended name:
    Histone H2B type 1-C/E/F/G/I
    Protein Accession:
    P62807
    Secondary Accessions:
    • P02278
    • Q3B872
    • Q4VB69
    • Q93078
    • Q93080

    Protein attributes for H2BC10 Gene

    Size:
    126 amino acids
    Molecular mass:
    13906 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for H2BC10 Gene

neXtProt entry for H2BC10 Gene

Post-translational modifications for H2BC10 Gene

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for H2BC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BC10 Gene

Domains & Families for H2BC10 Gene

Gene Families for H2BC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for H2BC10 Gene

Suggested Antigen Peptide Sequences for H2BC10 Gene

GenScript: Design optimal peptide antigens:
  • Histone H2B.l (H2B1C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62807

UniProtKB/Swiss-Prot:

H2B1C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BC10: view

Function for H2BC10 Gene

Molecular function for H2BC10 Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Phenotypes From GWAS Catalog for H2BC10 Gene

Gene Ontology (GO) - Molecular Function for H2BC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS,IBA 422550
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25954010
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BC10: view
genes like me logo Genes that share phenotypes with H2BC10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2BC10 Gene

Localization for H2BC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BC10 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2BC10 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for H2BC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 422550
GO:0005615 extracellular space IDA 12860195
GO:0005634 nucleus IEA,HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H2BC10: view

Pathways & Interactions for H2BC10 Gene

PathCards logo

SuperPathways for H2BC10 Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with H2BC10: view

Gene Ontology (GO) - Biological Process for H2BC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006334 nucleosome assembly IBA,NAS 422550
GO:0016567 protein ubiquitination TAS --
GO:0019731 antibacterial humoral response IDA 12860195
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with H2BC10: view

No data available for SIGNOR curated interactions for H2BC10 Gene

Drugs & Compounds for H2BC10 Gene

No Compound Related Data Available

Transcripts for H2BC10 Gene

mRNA/cDNA for H2BC10 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2BC10

Alternative Splicing Database (ASD) splice patterns (SP) for H2BC10 Gene

No ASD Table

Relevant External Links for H2BC10 Gene

GeneLoc Exon Structure for
H2BC10

Expression for H2BC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2BC10

SOURCE GeneReport for Unigene cluster for H2BC10 Gene:

Hs.553506

Evidence on tissue expression from TISSUES for H2BC10 Gene

  • Spleen(4.6)
  • Lung(4.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with H2BC10: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BC10 Gene

Orthologs for H2BC10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for H2BC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471888 30
  • 100 (n)
mouse
(Mus musculus)
Mammalia Hist1h2bc 30
  • 92.33 (n)
H2bc4 17
cow
(Bos Taurus)
Mammalia LOC616776 30
  • 92.06 (n)
dog
(Canis familiaris)
Mammalia LOC100856186 30
  • 91.8 (n)
rat
(Rattus norvegicus)
Mammalia Hist1h2bh 30
  • 89.15 (n)
Species where no ortholog for H2BC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H2BC10 Gene

ENSEMBL:
Gene Tree for H2BC10 (if available)
TreeFam:
Gene Tree for H2BC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H2BC10: view image

Paralogs for H2BC10 Gene

genes like me logo Genes that share paralogs with H2BC10: view

Variants for H2BC10 Gene

Additional dbSNP identifiers (rs#s) for H2BC10 Gene

Structural Variations from Database of Genomic Variants (DGV) for H2BC10 Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
nsv1023453 CNV gain 25217958
nsv428137 CNV loss 18775914
nsv601173 CNV loss 21841781

Variation tolerance for H2BC10 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H2BC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2BC10 Gene

Disorders for H2BC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for H2BC10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ehrlich tumor carcinoma
  • ehrlich's tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with H2BC10: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for H2BC10 Gene

Publications for H2BC10 Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 54
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4 54
  3. Antimicrobial peptides in the first line defence of human colon mucosa. (PMID: 12860195) Tollin M … Agerberth B (Peptides 2003) 3 4 54
  4. Human spleen histone H2B. Isolation and amino acid sequence. (PMID: 422550) Ohe Y … Iwai K (Journal of biochemistry 1979) 3 4 54
  5. Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. (PMID: 31542297) Bao X … Li XD (Molecular cell 2019) 4 54

Products for H2BC10 Gene

Sources for H2BC10 Gene