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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
H2AC20 (H2A Clustered Histone 20) is a Protein Coding gene. Diseases associated with H2AC20 include Riddle Syndrome and Xeroderma Pigmentosum Group E. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2AC18.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IEA,IDA | 16319397 |
GO:0005694 | chromosome | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Chromosome Maintenance | ||
4 | Cell Cycle, Mitotic |
.83
|
.60
|
5 | Chromatin organization |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IBA | 21873635 |
GO:0006342 | chromatin silencing | IBA | 21873635 |
GO:0008150 | biological_process | ND | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIST2H2AC 31 |
|
OneToOne | |
LOC457261 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | HIST2H2AC 31 |
|
OneToOne | |
LOC100855593 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | HIST2H2AC 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HIST3H2A 31 |
|
ManyToMany | |
HIST2H2AC 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Hist2h2ac 30 31 |
|
OneToOne | |
H2ac20 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Hist2h2ac 30 |
|
||
Chicken (Gallus gallus) |
Aves | H2A-VII 31 |
|
ManyToMany | |
LOC101749238 30 |
|
||||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486672 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | his-47 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0721900 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
riddle syndrome |
|
|
xeroderma pigmentosum group e |
|
|
angelman syndrome |
|
|
hyperinsulinemic hypoglycemia, familial, 2 |
|
|
hyperoxaluria, primary, type i |
|
|