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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H2AC20 Gene
Aliases for H2AC20 Gene
External Ids for H2AC20 Gene
- HGNC: 4738
- NCBI Entrez Gene: 8338
- Ensembl: ENSG00000184260
- OMIM®: 602797
- UniProtKB/Swiss-Prot: Q16777
Previous HGNC Symbols for H2AC20 Gene
- H2A
- H2AFQ
- HIST2H2AC
Previous GeneCards Identifiers for H2AC20 Gene
- GC01P149893
- GC01P149906
- GC01P149918
- GC01P149933
Summaries for H2AC20 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2AC20 Gene
H2AC20 (H2A Clustered Histone 20) is a Protein Coding gene. Diseases associated with H2AC20 include Riddle Syndrome and Xeroderma Pigmentosum Group E. Among its related pathways are Cellular Senescence (REACTOME) and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H2AJ.
UniProtKB/Swiss-Prot Summary for H2AC20 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H2AC20 Gene
- HGNC (4738)
- NCBI Entrez Gene (8338)
- Ensembl (ENSG00000184260)
- OMIM® (602797)
- UniProtKB/Swiss-Prot (Q16777)
- Open Targets Platform(ENSG00000184260)
- Alliance of Genome Resources
- Search for H2AC20 at DataMed
- Search for H2AC20 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2AC20 Gene
Genomics for H2AC20 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H2AC20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H2AC20 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2AC20
Genomic Locations for H2AC20 Gene
Latest Assembly
- chr1:149,886,918-149,887,411
- (GRCh38/hg38)
- Size:
- 494 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:149,858,468-149,858,961
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 494 bases
- Orientation:
- Plus strand
Genomic View for H2AC20 Gene
Genes around H2AC20 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by HGNC
- 1q21.2 by Entrez Gene
- 1q21.2 by Ensembl
H2AC20 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H2AC20 Gene
Proteins for H2AC20 Gene
-
Protein details for H2AC20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16777-H2A2C_HUMAN
- Recommended name:
- Histone H2A type 2-C
- Protein Accession:
- Q16777
- Q6DRA7
- Q8IUE5
Protein attributes for H2AC20 Gene
- Size:
- 129 amino acids
- Molecular mass:
- 13988 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H2AC20 Gene
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
-
Ubiquitination at Lys16
- NX_Q16777 (NX_Q16777-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H2AC20 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for H2AC20
-
Abcam antibodies for H2AC20
- Invitrogen Antibodies for H2AC20 (AFLGC-H2AC20)
- antibodies-online: Show 12 available HIST2H2AC Antibodies ranked by validation data
-
Biorbyt antibodies for H2AC20
-
Custom Antibody ServicesProSci Antibodies for H2AC20
Protein products for research
-
OriGene Purified Proteins for H2AC20
- Search Origene for MassSpec and Protein Over-expression Lysates for H2AC20
- Origene Custom Protein Services for H2AC20
- Novus Biologicals proteins for H2AC20
-
Abcam proteins for H2AC20
Assay products for research
No data available for DME Specific Peptides for H2AC20 Gene
Domains & Families for H2AC20 Gene
Gene Families for H2AC20 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for H2AC20 Gene
- InterPro:
- Blocks:
-
- Histone H2A
Suggested Antigen Peptide Sequences for H2AC20 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone H2A/q (H2A2C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16777- Family:
-
- Belongs to the histone H2A family.
Function for H2AC20 Gene
Molecular function for H2AC20 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H2AC20 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H2AC20 Gene
- GenomeRNAi human phenotypes for H2AC20:
-
- Increased vaccinia virus (VACV) infection
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased shRNA abundance (Z-score < -2)
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased NF-kappaB reporter expression
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in pancreas lineage
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H2AC20 - Starting at $85 >
- * H2AC20 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H2AC20
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC20
miRNA for H2AC20 Gene
- miRTarBase miRNAs that target H2AC20
-
- hsa-miR-1-3p (MIRT023579)
- hsa-miR-34a-5p (MIRT025241)
- hsa-miR-1301-3p (MIRT035964)
- hsa-miR-92b-3p (MIRT040707)
- hsa-miR-221-3p (MIRT046844)
- hsa-miR-133b (MIRT517422)
- hsa-miR-133a-3p (MIRT517423)
- hsa-miR-6848-3p (MIRT517424)
- hsa-miR-6843-3p (MIRT517425)
- hsa-miR-6741-5p (MIRT517426)
- hsa-miR-6736-5p (MIRT517427)
- hsa-miR-4701-3p (MIRT517428)
- hsa-miR-1262 (MIRT517429)
- hsa-miR-8057 (MIRT517430)
- hsa-miR-4483 (MIRT517431)
- hsa-miR-1293 (MIRT517432)
- hsa-miR-6766-5p (MIRT517433)
- hsa-miR-6756-5p (MIRT517434)
- hsa-miR-6745 (MIRT517435)
- hsa-miR-363-5p (MIRT517436)
- hsa-miR-760 (MIRT517437)
- hsa-miR-6822-3p (MIRT517438)
- hsa-miR-9-5p (MIRT517439)
- hsa-miR-520f-5p (MIRT517440)
- hsa-miR-1276 (MIRT517441)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2AC20
- Browse OriGene Inhibitory RNA Products For H2AC20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC20
Clone products for research
- Applied Biological Materials (abm): Clones for H2AC20 - Starting at $45 >
- * H2AC20 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H2AC20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2AC20
Cell Lines for research
-
Horizon Cell Lines for H2AC20
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2AC20 Gene
Localization for H2AC20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H2AC20 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IBA | -- |
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 16319397 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
Pathways & Interactions for H2AC20 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | Chromosome Maintenance | ||
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | Chromatin organization | ||
Pathways by source for H2AC20 Gene
58 Reactome pathways for H2AC20 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
4 KEGG pathways for H2AC20 Gene
1 GeneGo (Thomson Reuters) pathway for H2AC20 Gene
- Signal transduction Activin A signaling regulation
1 GeneTex pathway for H2AC20 Gene
Interacting Proteins for H2AC20 Gene
GPS-Prot Interaction Network for H2AC20
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006342 | chromatin silencing | IBA | 21873635 |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for H2AC20 Gene
Drugs & Compounds for H2AC20 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium | Nutra | 6959 |
Transcripts for H2AC20 Gene
mRNA/cDNA for H2AC20 Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000331380 494 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for H2AC20 - Starting at $85 >
- * H2AC20 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for H2AC20
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC20
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2AC20
- Browse OriGene Inhibitory RNA Products For H2AC20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC20
Clone products for research
- Applied Biological Materials (abm): Clones for H2AC20 - Starting at $45 >
- * H2AC20 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for H2AC20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2AC20
Relevant External Links for H2AC20 Gene
- GeneLoc Exon Structure for
- H2AC20
Expression for H2AC20 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2AC20
SOURCE GeneReport for Unigene cluster for H2AC20 Gene:
Hs.408067Evidence on tissue expression from TISSUES for H2AC20 Gene
- Blood(4.6)
- Lung(4.5)
- Liver(3)
- Muscle(2.9)
- Nervous system(2.8)
- Skin(2.7)
- Kidney(2.7)
- Stomach(2.6)
- Intestine(2.6)
- Heart(2.5)
- Spleen(2.5)
- Bone marrow(2.4)
- Pancreas(2.3)
- Lymph node(2)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for H2AC20
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2AC20 Gene
Orthologs for H2AC20 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HIST2H2AC 30 |
|
OneToOne | |
| LOC457261 29 |
|
||||
| Dog (Canis familiaris) |
Mammalia | HIST2H2AC 30 |
|
OneToOne | |
| LOC100855593 29 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | HIST2H2AC 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HIST3H2A 30 |
|
ManyToMany | |
| HIST2H2AC 29 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
ManyToMany | |
| Mouse (Mus musculus) |
Mammalia | Hist2h2ac 29 30 |
|
OneToOne | |
| H2ac20 16 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Hist2h2ac 29 |
|
||
| Chicken (Gallus gallus) |
Aves | H2A-VII 30 |
|
ManyToMany | |
| LOC101749238 29 |
|
||||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486672 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | his-47 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0721900 29 |
|
- Species where no ortholog for H2AC20 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for H2AC20 Gene
- ENSEMBL:
- Gene Tree for H2AC20 (if available)
- TreeFam:
- Gene Tree for H2AC20 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H2AC20: view image
- Alliance of Genome Resources:
- Additional Orthologs for H2AC20
Paralogs for H2AC20 Gene
Paralogs for H2AC20 Gene
Variants for H2AC20 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.05;
1.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H2AC20 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2AC20 Gene
Disorders for H2AC20 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| riddle syndrome |
|
|
| xeroderma pigmentosum group e |
|
|
| hyperoxaluria, primary, type i |
|
|
| hyperinsulinemic hypoglycemia, familial, 3 |
|
|
| angelman syndrome |
|
|
Search H2AC20 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for H2AC20
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for H2AC20 Gene
Publications for H2AC20 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PMID: 1469070) Collart D … Stein GS (Journal of cellular biochemistry 1992) 2 3 4
- USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. (PMID: 27083998) Wang Z … Zhang Z (Genes & development 2016) 3 4
- TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. (PMID: 25470042) Bhatnagar S … Green MR (Nature 2014) 3 4
- RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. (PMID: 22980979) Mattiroli F … Sixma TK (Cell 2012) 3 4
ExternalLinks
Products for H2AC20 Gene
- Custom Antibody Services
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- Custom Assay Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for H2AC20
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- OriGene qPCR primer pairs for H2AC20
- OriGene CRISPR knockouts for H2AC20
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- Sino Biological Human cDNA Clone for H2AC20
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins for H2AC20
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for H2AC20
- Abcam proteins for H2AC20
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- Invitrogen Antibodies for H2AC20 (AFLGC-H2AC20)
- VectorBuilder Custom and pre-made DNA vectors for H2AC20 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H2AC20 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for H2AC20 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H2AC20
- antibodies-online: Show 12 available HIST2H2AC Antibodies ranked by validation data
- antibodies-online: Search results for available HIST2H2AC related products ranked by validation data
- antibodies-online: Search results for available HIST2H2AC related products ranked by validation data
- Horizon Cell Lines for H2AC20
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2AC20
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H2AC20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC20
- Biorbyt antibodies for H2AC20
Sources for H2AC20 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
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