Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H2AC17 (H2A Clustered Histone 17) is a Protein Coding gene. Diseases associated with H2AC17 include Fanconi Anemia, Complementation Group A. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H2AC11.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027887 | Promoter/Enhancer | 2.3 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.3 | -296 | 11.9 | RNF2 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 | H2BC17 H2AC17 H3C12 piR-39028 piR-38252 piR-51953-002 piR-56252 ZKSCAN8 ZKSCAN4 ZSCAN9 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 15161933 |
GO:0019899 | enzyme binding | IPI | 17980597 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IEA,IDA | 16319397 |
GO:0005694 | chromosome | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
|
2 | Chromatin organization | ||
3 | Deubiquitination |
.74
|
|
4 | Metabolism of proteins | ||
5 | Necroptosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IBA | 21873635 |
GO:0006342 | chromatin silencing | IBA | 21873635 |
GO:0008150 | biological_process | ND | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471905 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LOC488254 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hist1h2ad 30 |
|
||
H2ac7 17 |
|
||||
Cow (Bos Taurus) |
Mammalia | LOC618824 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | LOC100910554 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
800317 | Likely Pathogenic: Multiple myeloma | 27,892,786(-) | C/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
fanconi anemia, complementation group a |
|
|