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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H2AC16 (H2A Clustered Histone 16) is a Protein Coding gene. Diseases associated with H2AC16 include Fanconi Anemia, Complementation Group A. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H2AC11.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027862 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +3.4 | 3351 | 12.7 | SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 IKZF1 POLR2A | H1-5 MN298282 piR-37468 piR-57285-002 piR-45037 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZNF603P | |
GH06J027851 | Enhancer | 0.3 | Ensembl | 0.4 | -13.9 | -13916 | 0.4 | ZBTB12 | ZNF603P H4C11 H3C12 H2BC13 H2BC12 lnc-HIST1H2AL-1 H2AC15 H2AC16 H2BC15 | |
GH06J027854 | Enhancer | 0.3 | Ensembl | 0.4 | -10.6 | -10616 | 1 | SPI1 | lnc-HIST1H2AL-1 H2BC16P H2AC16 H2AC15 H2BC15 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 15161933 |
GO:0019899 | enzyme binding | IPI | 17980597 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IEA,IDA | 16319397 |
GO:0005694 | chromosome | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
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2 | Chromatin organization | ||
3 | Deubiquitination |
.74
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4 | Metabolism of proteins | ||
5 | Necroptosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IBA | 21873635 |
GO:0006342 | chromatin silencing | IBA | 21873635 |
GO:0008150 | biological_process | ND | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471894 30 |
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Cow (Bos Taurus) |
Mammalia | LOC524176 30 |
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Mouse (Mus musculus) |
Mammalia | Hist1h2ae 30 |
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H2ac8 17 |
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Rat (Rattus norvegicus) |
Mammalia | Hist1h2ah 30 |
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Soybean (Glycine max) |
eudicotyledons | Gma.5443 30 |
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SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
800324 | Likely Pathogenic: Multiple myeloma | 27,865,398(+) | C/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
fanconi anemia, complementation group a |
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