Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H2AC16 Gene
Aliases for H2AC16 Gene
External Ids for H2AC16 Gene
- HGNC: 4730
- Entrez Gene: 8332
- Ensembl: ENSG00000276903
- OMIM: 602793
- UniProtKB: P0C0S8
Previous HGNC Symbols for H2AC16 Gene
- H2AFI
- HIST1H2AL
Summaries for H2AC16 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2AC16 Gene
H2AC16 (H2A Clustered Histone 16) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is H2AC13.
UniProtKB/Swiss-Prot Summary for H2AC16 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H2AC16 Gene
- Monarch Initiative
- Search for H2AC16 at DataMed
- Search for H2AC16 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2AC16 Gene
Genomics for H2AC16 Gene
GeneHancer (GH) Regulatory Elements for H2AC16 Gene
Promoters and enhancers for H2AC16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H2AC16 on UCSC Golden Path with GeneCards custom track
Genomic Locations for H2AC16 Gene
Genomic Locations for H2AC16 Gene
- chr6:27,865,329-27,865,798
- (GRCh38/hg38)
- Size:
- 470 bases
- Orientation:
- Plus strand
- chr6:27,833,034-27,833,606
- (GRCh37/hg19)
- Size:
- 573 bases
- Orientation:
- Plus strand
Genomic View for H2AC16 Gene
Genes around H2AC16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
H2AC16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H2AC16 Gene
Proteins for H2AC16 Gene
-
Protein details for H2AC16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C0S8-H2A1_HUMAN
- Recommended name:
- Histone H2A type 1
- Protein Accession:
- P0C0S8
- P02261
- Q2M1R2
- Q76PA6
Protein attributes for H2AC16 Gene
- Size:
- 130 amino acids
- Molecular mass:
- 14091 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H2AC16 Gene
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
-
Ubiquitination at Lys16
- NX_P0C0S8 (NX_P0C0S8-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H2AC16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
-
OriGene Purified Proteins for H2AC16
- Search Origene for MassSpec and Protein Over-expression Lysates for H2AC16
- Origene Custom Protein Services for H2AC16
No data available for DME Specific Peptides for H2AC16 Gene
Domains & Families for H2AC16 Gene
Gene Families for H2AC16 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for H2AC16 Gene
- Blocks:
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P0C0S8- Family:
-
- Belongs to the histone H2A family.
No data available for Suggested Antigen Peptide Sequences for H2AC16 Gene
Function for H2AC16 Gene
Molecular function for H2AC16 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H2AC16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0019899 | enzyme binding | IPI | 17980597 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H2AC16 Gene
- GenomeRNAi human phenotypes for H2AC16:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * H2AC16 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for H2AC16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC16
- genomics-online: gRNA clones - Search for available HIST1H2AL gRNA products
- Overview of 42 available HIST1H2AL gene related products
miRNA for H2AC16 Gene
- miRTarBase miRNAs that target H2AC16
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for H2AC16
- Browse OriGene Inhibitory RNA Products For H2AC16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC16
- genomics-online: shRNA clones - Search for available HIST1H2AL shRNA products
- Overview of 42 available HIST1H2AL gene related products
Clone Products
- Applied Biological Materials (abm): Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * H2AC16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for H2AC16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2AC16
Cell Line Products
-
Horizon Cell Lines for H2AC16
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2AC16 Gene
Localization for H2AC16 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H2AC16 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA | 21873635 |
| GO:0005634 | nucleus | IDA | 16319397 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H2AC16 Gene
Pathways & Interactions for H2AC16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 2 | Chromatin organization | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Necroptosis | ||
Pathways by source for H2AC16 Gene
1 BioSystems pathway for H2AC16 Gene
11 Reactome pathways for H2AC16 Gene
3 KEGG pathways for H2AC16 Gene
1 GeneGo (Thomson Reuters) pathway for H2AC16 Gene
Interacting Proteins for H2AC16 Gene
GPS-Prot Interaction Network for H2AC16
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IBA | 21873635 |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for H2AC16 Gene
Transcripts for H2AC16 Gene
mRNA/cDNA for H2AC16 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000613174 393 bps (ENST00000613174.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * H2AC16 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for H2AC16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC16
- genomics-online: gRNA clones - Search for available HIST1H2AL gRNA products
- Overview of 42 available HIST1H2AL gene related products
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for H2AC16
- Browse OriGene Inhibitory RNA Products For H2AC16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC16
- genomics-online: shRNA clones - Search for available HIST1H2AL shRNA products
- Overview of 42 available HIST1H2AL gene related products
Clone Products
- Applied Biological Materials (abm): Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * H2AC16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for H2AC16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2AC16
Expression for H2AC16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
NURSA nuclear receptor signaling pathways regulating expression of H2AC16 Gene:
H2AC16SOURCE GeneReport for Unigene cluster for H2AC16 Gene:
Hs.233568Evidence on tissue expression from TISSUES for H2AC16 Gene
- Intestine(4.3)
- Spleen(4.3)
Primer Products
-
OriGene qPCR primer pairs for H2AC16
-
OriGene qPCR primer pairs and template standards for H2AC16
- genomics-online: primer clones - Search for available HIST1H2AL Primer products
- Overview of 42 available HIST1H2AL gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2AC16 Gene
Orthologs for H2AC16 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC471894 32 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC524176 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h2ae 32 |
|
||
| H2ac8 17 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Hist1h2ah 32 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.5443 32 |
|
- Species where no ortholog for H2AC16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for H2AC16 Gene
- ENSEMBL:
- Gene Tree for H2AC16 (if available)
- TreeFam:
- Gene Tree for H2AC16 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H2AC16: view image
Paralogs for H2AC16 Gene
Paralogs for H2AC16 Gene
Variants for H2AC16 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001236854 | -- | 27,865,086(+) | T/G | upstream_transcript_variant | |
| rs1002061183 | -- | 27,865,037(+) | A/C | upstream_transcript_variant | |
| rs1003007604 | -- | 27,864,720(+) | A/C | upstream_transcript_variant | |
| rs1003944405 | -- | 27,864,739(+) | A/G | upstream_transcript_variant | |
| rs1005064455 | -- | 27,864,099(+) | C/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H2AC16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H2AC16
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2AC16 Gene
Disorders for H2AC16 Gene
No disorders were found for H2AC16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for H2AC16 Gene
Publications for H2AC16 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 56
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 56
- Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne MT … Kelleher NL (Journal of proteome research 2006) 3 4 56
- The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W … Doenecke D (Biological chemistry 1999) 3 4 56
- Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W … Doenecke D (Gene 1997) 2 3 56
ExternalLinks
Products for H2AC16 Gene
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- Custom Assay Services
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- Origene Custom Protein Services for H2AC16
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- Browse OriGene Inhibitory RNA Products For H2AC16
- OriGene qPCR primer pairs for H2AC16
- OriGene qPCR primer pairs and template standards for H2AC16
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- OriGene ORF clones in human for H2AC16
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- Sino Biological Human cDNA Clone for H2AC16
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- antibodies-online: Show 8 available HIST1H2AL Antibodies ranked by validation data
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- antibodies-online: Search results for available HIST1H2AL related products ranked by validation data
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- Horizon Cell Lines for H2AC16
- genomics-online: cdna clones - Search for available HIST1H2AL CDNA products
- Overview of 42 available HIST1H2AL gene related products
- orf clones - Search for available HIST1H2AL ORF products
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- genomics-online: primer clones - Search for available HIST1H2AL Primer products
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- genomics-online: shRNA clones - Search for available HIST1H2AL shRNA products
- Overview of 42 available HIST1H2AL gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC16
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for H2AC16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC16
Sources for H2AC16 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
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- (180) MyBioSource