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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and ... See more...
Aliases for H2AC16 Gene
Aliases for H2AC16 Gene
External Ids for H2AC16 Gene
- HGNC: 4730
- Entrez Gene: 8332
- Ensembl: ENSG00000276903
- OMIM: 602793
- UniProtKB: P0C0S8
Previous HGNC Symbols for H2AC16 Gene
- H2AFI
- HIST1H2AL
Previous GeneCards Identifiers for H2AC16 Gene
- GC06P027939
- GC06P028146
Summaries for H2AC16 Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2AC16 Gene
H2AC16 (H2A Clustered Histone 16) is a Protein Coding gene. Diseases associated with H2AC16 include Fanconi Anemia, Complementation Group A. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H2AC11.
UniProtKB/Swiss-Prot Summary for H2AC16 Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for H2AC16 Gene
- HGNC(4730)
- Entrez Gene(8332)
- Ensembl(ENSG00000276903)
- OMIM(602793)
- UniProtKB(P0C0S8)
- Open Targets Platform(ENSG00000276903)
- Monarch Initiative
- Search for H2AC16 at DataMed
- Search for H2AC16 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H2AC16 Gene
Genomics for H2AC16 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H2AC16 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J027862 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +3.4 | 3351 | 12.7 | SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 IKZF1 POLR2A | H1-5 MN298282 piR-37468 piR-57285-002 piR-45037 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZNF603P | |
| GH06J027851 | Enhancer | 0.3 | Ensembl | 0.4 | -13.9 | -13916 | 0.4 | ZBTB12 | ZNF603P H4C11 H3C12 H2BC13 H2BC12 lnc-HIST1H2AL-1 H2AC15 H2AC16 H2BC15 | |
| GH06J027854 | Enhancer | 0.3 | Ensembl | 0.4 | -10.6 | -10616 | 1 | SPI1 | lnc-HIST1H2AL-1 H2BC16P H2AC16 H2AC15 H2BC15 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H2AC16 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H2AC16
Genomic Locations for H2AC16 Gene
Genomic Locations for H2AC16 Gene
- chr6:27,865,317-27,865,798
- (GRCh38/hg38)
- Size:
- 482 bases
- Orientation:
- Plus strand
- chr6:27,833,034-27,833,606
- (GRCh37/hg19)
- Size:
- 573 bases
- Orientation:
- Plus strand
Genomic View for H2AC16 Gene
Genes around H2AC16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
H2AC16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H2AC16 Gene
Proteins for H2AC16 Gene
-
Protein details for H2AC16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C0S8-H2A1_HUMAN
- Recommended name:
- Histone H2A type 1
- Protein Accession:
- P0C0S8
- P02261
- Q2M1R2
- Q76PA6
Protein attributes for H2AC16 Gene
- Size:
- 130 amino acids
- Molecular mass:
- 14091 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Post-translational modifications for H2AC16 Gene
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
-
Ubiquitination at Lys16
- NX_P0C0S8 (NX_P0C0S8-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H2AC16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
-
OriGene Purified Proteins for H2AC16
- Search Origene for MassSpec and Protein Over-expression Lysates for H2AC16
- Origene Custom Protein Services for H2AC16
No data available for DME Specific Peptides for H2AC16 Gene
Domains & Families for H2AC16 Gene
Gene Families for H2AC16 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for H2AC16 Gene
- InterPro:
- Blocks:
-
- Histone H2A
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P0C0S8- Family:
-
- Belongs to the histone H2A family.
No data available for Suggested Antigen Peptide Sequences for H2AC16 Gene
Function for H2AC16 Gene
Molecular function for H2AC16 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for H2AC16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0019899 | enzyme binding | IPI | 17980597 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for H2AC16 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H2AC16 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H2AC16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC16
miRNA for H2AC16 Gene
- miRTarBase miRNAs that target H2AC16
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2AC16
- Browse OriGene Inhibitory RNA Products For H2AC16
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Clone Products
- Applied Biological Materials (abm): Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for H2AC16
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Cell Line Products
-
Horizon Cell Lines for H2AC16
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H2AC16 Gene
Localization for H2AC16 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H2AC16 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA | 21873635 |
| GO:0005634 | nucleus | IEA,IDA | 16319397 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H2AC16 Gene
Pathways & Interactions for H2AC16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
|
| 2 | Chromatin organization | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Necroptosis | ||
Pathways by source for H2AC16 Gene
1 BioSystems pathway for H2AC16 Gene
11 Reactome pathways for H2AC16 Gene
3 KEGG pathways for H2AC16 Gene
1 GeneGo (Thomson Reuters) pathway for H2AC16 Gene
- Signal transduction Activin A signaling regulation
Interacting Proteins for H2AC16 Gene
Selected Interacting proteins:
P0C0S8-H2A1_HUMAN
ENSP00000482538
for H2AC16 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H2AC16
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IBA | 21873635 |
| GO:0006342 | chromatin silencing | IBA | 21873635 |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for H2AC16 Gene
Transcripts for H2AC16 Gene
mRNA/cDNA for H2AC16 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000613174 482 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H2AC16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H2AC16
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H2AC16
- Browse OriGene Inhibitory RNA Products For H2AC16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H2AC16
Clone Products
- Applied Biological Materials (abm): Clones for H2AC16 - Select products 50% OFF >
- * H2AC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H2AC16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H2AC16
Relevant External Links for H2AC16 Gene
- GeneLoc Exon Structure for
- H2AC16
Expression for H2AC16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H2AC16
SOURCE GeneReport for Unigene cluster for H2AC16 Gene:
Hs.233568Evidence on tissue expression from TISSUES for H2AC16 Gene
- Intestine(4.4)
- Spleen(4.3)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for H2AC16
-
OriGene qPCR primer pairs and template standards for H2AC16
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2AC16 Gene
Orthologs for H2AC16 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC471894 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | LOC524176 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hist1h2ae 30 |
|
||
| H2ac8 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Hist1h2ah 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.5443 30 |
|
- Species where no ortholog for H2AC16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for H2AC16 Gene
- ENSEMBL:
- Gene Tree for H2AC16 (if available)
- TreeFam:
- Gene Tree for H2AC16 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H2AC16: view image
Paralogs for H2AC16 Gene
Paralogs for H2AC16 Gene
Variants for H2AC16 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H2AC16 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 800324 | Likely Pathogenic: Multiple myeloma | 27,865,398(+) | C/G | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H2AC16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H2AC16
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2AC16 Gene
Disorders for H2AC16 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi anemia, complementation group a |
|
|
Search H2AC16 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for H2AC16
No data available for UniProtKB/Swiss-Prot and Genatlas for H2AC16 Gene
Publications for H2AC16 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4
- Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne MT … Kelleher NL (Journal of proteome research 2006) 3 4
- The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W … Doenecke D (Biological chemistry 1999) 3 4
- Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W … Doenecke D (Gene 1997) 2 3
ExternalLinks
Products for H2AC16 Gene
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- OriGene qPCR primer pairs for H2AC16
- OriGene qPCR primer pairs and template standards for H2AC16
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- Sino Biological Human cDNA Clone for H2AC16
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- High-throughput Antibody Production Service
- Protein Production Service
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- antibodies-online: Show 8 available HIST1H2AL Antibodies ranked by validation data
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- antibodies-online: Search results for available HIST1H2AL related products ranked by validation data
- antibodies-online: Search results for available HIST1H2AL related products ranked by validation data
- Horizon Cell Lines for H2AC16
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Sources for H2AC16 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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