Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H2AC14 (H2A Clustered Histone 14) is a Protein Coding gene. Diseases associated with H2AC14 include Riddle Syndrome. Among its related pathways are Chromatin organization and Signaling by GPCR. An important paralog of this gene is H2AC11.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027834 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 7.7 | -22.7 | -22664 | 6.7 | ZNF221 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 | H2BC15 H2AC15 ZSCAN12 ZKSCAN8 ZKSCAN3 ZSCAN9 ZSCAN26 ZKSCAN4 PGBD1 GUSBP2 | |
GH06J027887 | Promoter/Enhancer | 2.3 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 4 | -78.7 | -78704 | 11.9 | RNF2 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 | H2BC17 H2AC17 H3C12 piR-39028 piR-38252 piR-51953-002 piR-56252 ZKSCAN8 ZKSCAN4 ZSCAN9 | |
GH06J027805 | Promoter/Enhancer | 2.3 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 3 | +2.7 | 2662 | 12.7 | ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 | Z46261-004 piR-57462 ZKSCAN4 ZSCAN9 ZKSCAN8 ZKSCAN3 ZSCAN12 ZNF603P ZSCAN26 GUSBP2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0003677 | DNA binding | IBA | -- |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005694 | chromosome | IEA | -- |
GO:0070062 | extracellular exosome | HDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.35
|
2 | Cellular Senescence (REACTOME) | ||
3 | Chromosome Maintenance | ||
4 | Cell Cycle, Mitotic |
.83
|
.60
|
5 | Chromatin organization |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IBA | -- |
GO:0006342 | chromatin silencing | IBA | -- |
GO:0008150 | biological_process | ND | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC737087 30 |
|
||
Cow (Bos Taurus) |
Mammalia | HIST1H2AJ 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LOC488304 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hist1h2af 30 |
|
||
H2ac10 17 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3890803 | CNV | loss | 25118596 |
nsv1017057 | CNV | gain | 25217958 |
nsv830618 | CNV | gain | 17160897 |
nsv970094 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
riddle syndrome |
|
|