Aliases for H2AC12 Gene
External Ids for H2AC12 Gene
Previous HGNC Symbols for H2AC12 Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
GeneCards Summary for H2AC12 Gene
H2AC12 (H2A Clustered Histone 12) is a Protein Coding gene. Diseases associated with H2AC12 include Wilson-Turner X-Linked Mental Retardation Syndrome and Syndromic Intellectual Disability. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is H2AC11.
UniProtKB/Swiss-Prot Summary for H2AC12 Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.