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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
H2AC11 (H2A Clustered Histone 11) is a Protein Coding gene. Diseases associated with H2AC11 include Riddle Syndrome. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is H2AC13.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027126 | Promoter/Enhancer | 2.5 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +5.0 | 4980 | 23 | BRCA1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 | H4C9 H2BC11 ABT1 HMGN4 BTN2A2 BTN2A1 ZNF322 ENSG00000261584 BTN2A3P GUSBP2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 15161933 |
GO:0019899 | enzyme binding | IPI | 17980597 |
GO:0046982 | protein heterodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IEA,IDA | 16319397 |
GO:0005694 | chromosome | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
|
2 | Chromatin organization | ||
3 | Deubiquitination |
.74
|
|
4 | Metabolism of proteins | ||
5 | Necroptosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IBA | 21873635 |
GO:0006342 | chromatin silencing | IBA | 21873635 |
GO:0008150 | biological_process | ND | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2AG 31 |
|
OneToOne | |
LOC736529 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | HIST1H2AG 31 |
|
OneToOne | |
LOC529277 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
LOC488297 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Hist1h2af 31 |
|
ManyToMany | |
Hist1h2an 30 |
|
||||
H2ac22 17 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Rat (Rattus norvegicus) |
Mammalia | Hist1h2ai 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | zgc56329 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.644 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1029124 | CNV | loss | 25217958 |
nsv970090 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
riddle syndrome |
|
|