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Aliases for H1FNT Gene

Aliases for H1FNT Gene

  • H1 Histone Family Member N, Testis Specific 2 3 5
  • Haploid Germ Cell-Specific Nuclear Protein 1 3 4
  • Histone H1t2 3 4
  • HANP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 223n 3
  • H1 Histone Family, Member N, Testis-Specific 2
  • Testis-Specific H1 Histone 3
  • H1.7 3
  • H1T2 3

External Ids for H1FNT Gene

Previous GeneCards Identifiers for H1FNT Gene

  • GC12P047012
  • GC12P048722
  • GC12P045755

Summaries for H1FNT Gene

Entrez Gene Summary for H1FNT Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1FNT Gene

H1FNT (H1 Histone Family Member N, Testis Specific) is a Protein Coding gene.

UniProtKB/Swiss-Prot for H1FNT Gene

  • Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.

Additional gene information for H1FNT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H1FNT Gene

Genomics for H1FNT Gene

GeneHancer (GH) Regulatory Elements for H1FNT Gene

Promoters and enhancers for H1FNT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I048156 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 15.7 -171.5 -171525 2.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF143 ASB8 PFKM RPL37P19 ZNF641 H1FNT SENP1 RNU6-1203P CCDC184 TMEM106C ENSG00000274124
GH12I048104 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.9 -222.7 -222690 4.1 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SENP1 PFKM DDX23 KMT2D CCNT1 LOC390314 KANSL2 RPL37P19 OR5BK1P HDAC7
GH12I048307 Enhancer 0.5 FANTOM5 57 -21.5 -21479 0.1 IRF2 PKNOX1 GABPB1 LOC105369753 H1FNT C12orf54 PFKM SENP1 ENSG00000275228
GH12I047704 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 12 -622.6 -622640 2.8 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 ENSG00000257433 LOC105369748 RPAP3 OR5BK1P VDR SLC48A1 RAPGEF3 H1FNT HDAC7 SENP1
GH12I048118 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.9 -209.4 -209416 2.2 HDGF PKNOX1 SIN3A ZNF2 ZNF121 SP3 GMEB1 SMARCA4 NBN KDM1A PFKM RPL37P19 ZNF641 LOC390314 DDX23 CCNT1 H1FNT CCDC184 ASB8 GC12P048122
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around H1FNT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the H1FNT gene promoter:

Genomic Locations for H1FNT Gene

Genomic Locations for H1FNT Gene
chr12:48,328,980-48,330,279
(GRCh38/hg38)
Size:
1,300 bases
Orientation:
Plus strand
chr12:48,722,763-48,724,062
(GRCh37/hg19)

Genomic View for H1FNT Gene

Genes around H1FNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1FNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1FNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1FNT Gene

Proteins for H1FNT Gene

  • Protein details for H1FNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75WM6-H1FNT_HUMAN
    Recommended name:
    Testis-specific H1 histone
    Protein Accession:
    Q75WM6
    Secondary Accessions:
    • Q147U8
    • Q5GKZ5
    • Q7Z694

    Protein attributes for H1FNT Gene

    Size:
    255 amino acids
    Molecular mass:
    28116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD13382.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for H1FNT Gene

Post-translational modifications for H1FNT Gene

No Post-translational modifications

Other Protein References for H1FNT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1FNT Gene

Domains & Families for H1FNT Gene

Gene Families for H1FNT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H1FNT Gene

ProtoNet:

Suggested Antigen Peptide Sequences for H1FNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75WM6

UniProtKB/Swiss-Prot:

H1FNT_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1FNT: view

Function for H1FNT Gene

Molecular function for H1FNT Gene

UniProtKB/Swiss-Prot Function:
Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.

Phenotypes From GWAS Catalog for H1FNT Gene

Gene Ontology (GO) - Molecular Function for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with H1FNT: view
genes like me logo Genes that share phenotypes with H1FNT: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H1FNT Gene

Localization for H1FNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1FNT Gene

Nucleus. Chromosome. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250 UniProtKB:Q8CJI4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H1FNT gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS 15710904
GO:0005634 nucleus IEA,HDA 21630459
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H1FNT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H1FNT Gene

Pathways & Interactions for H1FNT Gene

SuperPathways for H1FNT Gene

No Data Available

Interacting Proteins for H1FNT Gene

Gene Ontology (GO) - Biological Process for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007290 spermatid nucleus elongation ISS 15710904
GO:0030154 cell differentiation IEA --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with H1FNT: view

No data available for Pathways by source and SIGNOR curated interactions for H1FNT Gene

Drugs & Compounds for H1FNT Gene

No Compound Related Data Available

Transcripts for H1FNT Gene

mRNA/cDNA for H1FNT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H1FNT Gene

H1 histone family, member N, testis-specific:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1FNT Gene

No ASD Table

Relevant External Links for H1FNT Gene

GeneLoc Exon Structure for
H1FNT
ECgene alternative splicing isoforms for
H1FNT

Expression for H1FNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for H1FNT Gene

mRNA differential expression in normal tissues according to GTEx for H1FNT Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for H1FNT Gene

This gene is overexpressed in Esophagus (39.2), Pancreatic juice (8.1), Peripheral blood mononuclear cells (6.9), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for H1FNT Gene



Protein tissue co-expression partners for H1FNT Gene

NURSA nuclear receptor signaling pathways regulating expression of H1FNT Gene:

H1FNT

SOURCE GeneReport for Unigene cluster for H1FNT Gene:

Hs.155833

mRNA Expression by UniProt/SwissProt for H1FNT Gene:

Q75WM6-H1FNT_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with H1FNT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1FNT Gene

Orthologs for H1FNT Gene

This gene was present in the common ancestor of mammals.

Orthologs for H1FNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H1FNT 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia LOC609303 33
  • 73.44 (n)
H1FNT 34
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H1FNT 33
  • 72.15 (n)
mouse
(Mus musculus)
Mammalia H1fnt 34
  • 32 (a)
OneToOne
Species where no ortholog for H1FNT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H1FNT Gene

ENSEMBL:
Gene Tree for H1FNT (if available)
TreeFam:
Gene Tree for H1FNT (if available)

Paralogs for H1FNT Gene

No data available for Paralogs for H1FNT Gene

Variants for H1FNT Gene

Sequence variations from dbSNP and Humsavar for H1FNT Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000417144 -- 48,330,441(+) A/G downstream_transcript_variant
rs1000650905 -- 48,328,320(+) G/A upstream_transcript_variant
rs1001919887 -- 48,329,736(+) G/C coding_sequence_variant, missense_variant
rs1003343737 -- 48,328,407(+) A/C upstream_transcript_variant
rs1003443892 -- 48,328,088(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for H1FNT Gene

Variant ID Type Subtype PubMed ID
esv2759898 CNV gain+loss 17122850
esv34439 CNV gain 17911159
esv3629436 CNV gain 21293372
nsv1160031 CNV deletion 26073780
nsv437752 CNV loss 16327808
nsv826362 CNV gain 20364138
nsv832402 CNV gain 17160897
nsv8971 CNV gain+loss 18304495

Variation tolerance for H1FNT Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H1FNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1FNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1FNT Gene

Disorders for H1FNT Gene

Additional Disease Information for H1FNT

No disorders were found for H1FNT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H1FNT Gene

Publications for H1FNT Gene

  1. Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. (PMID: 16533358) Tanaka H … Nishimune Y (International journal of andrology 2006) 3 4 22 58
  2. Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. (PMID: 15710904) Martianov I … Davidson I (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 58
  5. Histone variants: key players of chromatin. (PMID: 24781148) Biterge B … Schneider R (Cell and tissue research 2014) 3 58

Products for H1FNT Gene

Sources for H1FNT Gene

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