This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008] See more...

Aliases for H1-9P Gene

Aliases for H1-9P Gene

  • H1.9 Linker Histone, Pseudogene 2 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene) 2 3
  • Spermatid-Specific Linker Histone H1-Like Protein 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 2
  • H1.9 Linker Histone (Pseudogene) 2
  • HILS1 3
  • H1.9 3
  • H1-9 3

External Ids for H1-9P Gene

Previous HGNC Symbols for H1-9P Gene

  • HILS1
  • H1-9

Summaries for H1-9P Gene

Entrez Gene Summary for H1-9P Gene

  • This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for H1-9P Gene

H1-9P (H1.9 Linker Histone, Pseudogene) is a Pseudogene. Among its related pathways are Transcription_CREM signaling in testis.

Additional gene information for H1-9P Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-9P Gene

Genomics for H1-9P Gene

GeneHancer (GH) Regulatory Elements for H1-9P Gene

Promoters and enhancers for H1-9P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050172 Enhancer 0.7 ENCODE 500.7 +1.3 1301 0.2 TRIM22 BCL11A TCF12 ARNT MEF2B FOSL1 SMARCA5 BATF IRF4 EBF1 H1-9P SGCA LOC105371818
GH17J050171 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -20.0 -20046 42 HNRNPK ZNF217 CTCF SIN3A TCF12 MYC POLR2G USF1 JUND FOS COL1A1 SGCA ENSG00000262837 LUC7L3 TMEM92-AS1 TMEM92 XYLT2 PPP1R9B FLJ45513 ENSG00000253730
GH17J050168 Promoter/Enhancer 1.3 Ensembl ENCODE 0.7 +2.8 2839 1.6 ZNF217 CTCF MYC TCF12 RBAK TEAD4 ZNF639 ZIC2 ZBTB10 GABPA SGCA COL1A1 ENSG00000262837 FAM117A CACNA1G-AS1 PICART1 NXPH3 ENSG00000250286 H1-9P LOC105371818
GH17J050169 Promoter 0.3 Ensembl 0.7 +4.5 4475 0.4 LOC105371818 SGCA H1-9P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H1-9P on UCSC Golden Path with GeneCards custom track

Genomic Locations for H1-9P Gene

Genomic Locations for H1-9P Gene
chr17:50,171,428-50,172,476
(GRCh38/hg38)
Size:
1,049 bases
Orientation:
Minus strand

Genomic View for H1-9P Gene

Genes around H1-9P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1-9P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1-9P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1-9P Gene

Proteins for H1-9P Gene

Post-translational modifications for H1-9P Gene

No Post-translational modifications

No data available for DME Specific Peptides for H1-9P Gene

Domains & Families for H1-9P Gene

Gene Families for H1-9P Gene

HGNC:

Suggested Antigen Peptide Sequences for H1-9P Gene

GenScript: Design optimal peptide antigens:
  • Spermatid-specific linker histone H1-like protein (HILS1_HUMAN)
genes like me logo Genes that share domains with H1-9P: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for H1-9P Gene

Function for H1-9P Gene

Phenotypes From GWAS Catalog for H1-9P Gene

Gene Ontology (GO) - Molecular Function for H1-9P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IDA 12920187
GO:0003690 double-stranded DNA binding IBA 21873635
GO:0031492 nucleosomal DNA binding IBA 21873635
GO:0042393 histone binding IDA 12920187
genes like me logo Genes that share ontologies with H1-9P: view
genes like me logo Genes that share phenotypes with H1-9P: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-9P

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H1-9P Gene

Localization for H1-9P Gene

Gene Ontology (GO) - Cellular Components for H1-9P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12920187
GO:0000790 nuclear chromatin IBA 21873635
GO:0001673 male germ cell nucleus IDA 12920187
GO:0005634 nucleus IBA 21873635
GO:0005719 nuclear euchromatin IBA 21873635
genes like me logo Genes that share ontologies with H1-9P: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for H1-9P Gene

Pathways & Interactions for H1-9P Gene

PathCards logo

SuperPathways for H1-9P Gene

SuperPathway Contained pathways
1 Transcription_CREM signaling in testis
-
genes like me logo Genes that share pathways with H1-9P: view

Pathways by source for H1-9P Gene

1 GeneGo (Thomson Reuters) pathway for H1-9P Gene
  • Transcription_CREM signaling in testis
;

Gene Ontology (GO) - Biological Process for H1-9P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006338 chromatin remodeling NAS 12920187
GO:0006342 chromatin silencing IDA 12920187
GO:0006355 regulation of transcription, DNA-templated NAS 12920187
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with H1-9P: view

No data available for Interacting Proteins and SIGNOR curated interactions for H1-9P Gene

Drugs & Compounds for H1-9P Gene

(1) Drugs for H1-9P Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with H1-9P: view

Transcripts for H1-9P Gene

mRNA/cDNA for H1-9P Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-9P

Alternative Splicing Database (ASD) splice patterns (SP) for H1-9P Gene

No ASD Table

Relevant External Links for H1-9P Gene

GeneLoc Exon Structure for
H1-9P

Expression for H1-9P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-9P

SOURCE GeneReport for Unigene cluster for H1-9P Gene:

Hs.25934
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-9P Gene

Orthologs for H1-9P Gene

No data available for Orthologs and Evolution for H1-9P Gene

Paralogs for H1-9P Gene

No data available for Paralogs for H1-9P Gene

Variants for H1-9P Gene

Structural Variations from Database of Genomic Variants (DGV) for H1-9P Gene

Variant ID Type Subtype PubMed ID
nsv507842 OTHER sequence alteration 20534489
nsv952339 CNV deletion 24416366

Additional Variant Information for H1-9P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1-9P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for H1-9P Gene

Disorders for H1-9P Gene

No disorders were found for H1-9P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for H1-9P Gene

Publications for H1-9P Gene

  1. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. (PMID: 12920187) Yan W … Matzuk MM (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 23 54
  2. Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements. (PMID: 30068355) Mishra LN … Rao MRS (Epigenetics & chromatin 2018) 2 3 54
  3. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P … Jagodzinski PP (Archives of andrology 2007) 3 23 54
  4. Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells. (PMID: 14636221) Iguchi N … Nishimune Y (International journal of andrology 2003) 3 23 54
  5. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 54

Products for H1-9P Gene

Sources for H1-9P Gene