This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008] See more...

Aliases for H1-9P Gene

Aliases for H1-9P Gene

  • H1.9 Linker Histone, Pseudogene 2 3 5
  • Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene) 2 3
  • HILS1 3 4
  • H1-9 3 4
  • H1.9 2 3
  • Putative Spermatid-Specific Linker Histone H1-Like Protein 4
  • Spermatid-Specific Linker Histone H1-Like Protein 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 2
  • H1.9 Linker Histone (Pseudogene) 2
  • H1.9 Linker Histone Pseudogene 4
  • H1-9P 5

External Ids for H1-9P Gene

Previous HGNC Symbols for H1-9P Gene

  • HILS1
  • H1-9

Summaries for H1-9P Gene

Entrez Gene Summary for H1-9P Gene

  • This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for H1-9P Gene

H1-9P (H1.9 Linker Histone, Pseudogene) is a Pseudogene. Among its related pathways are Transcription_CREM signaling in testis.

UniProtKB/Swiss-Prot Summary for H1-9P Gene

  • DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-9P Gene

Genomics for H1-9P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for H1-9P Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H1-9P on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for H1-9P Gene

Latest Assembly
chr17:50,171,428-50,181,178
(GRCh38/hg38)
Size:
9,751 bases
Orientation:
Minus strand

Previous Assembly
chr17:48,248,789-48,249,837
(GRCh37/hg19 by Entrez Gene)
Size:
1,049 bases
Orientation:
Minus strand

chr17:48,248,789-48,258,539
(GRCh37/hg19 by Ensembl)
Size:
9,751 bases
Orientation:
Minus strand

Genomic View for H1-9P Gene

Genes around H1-9P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1-9P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1-9P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1-9P Gene

Proteins for H1-9P Gene

  • Protein details for H1-9P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60008-HILS1_HUMAN
    Recommended name:
    Putative spermatid-specific linker histone H1-like protein
    Protein Accession:
    P60008

    Protein attributes for H1-9P Gene

    Size:
    231 amino acids
    Molecular mass:
    25632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for H1-9P Gene

Post-translational modifications for H1-9P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for H1-9P Gene

Domains & Families for H1-9P Gene

Gene Families for H1-9P Gene

HGNC:

Protein Domains for H1-9P Gene

InterPro:
Blocks:
  • Histone H1/H5

Suggested Antigen Peptide Sequences for H1-9P Gene

GenScript: Design optimal peptide antigens:
  • Spermatid-specific linker histone H1-like protein (HILS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60008

UniProtKB/Swiss-Prot:

HILS1_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1-9P: view

Function for H1-9P Gene

Molecular function for H1-9P Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

Phenotypes From GWAS Catalog for H1-9P Gene

Gene Ontology (GO) - Molecular Function for H1-9P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IDA 12920187
GO:0003690 double-stranded DNA binding IBA 21873635
GO:0031492 nucleosomal DNA binding IBA 21873635
GO:0042393 histone binding IDA 12920187
genes like me logo Genes that share ontologies with H1-9P: view
genes like me logo Genes that share phenotypes with H1-9P: view

Animal Models for research

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-9P

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H1-9P Gene

Localization for H1-9P Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1-9P Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for H1-9P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12920187
GO:0001673 male germ cell nucleus IDA 12920187
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with H1-9P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for H1-9P Gene

Pathways & Interactions for H1-9P Gene

PathCards logo

SuperPathways for H1-9P Gene

SuperPathway Contained pathways
1 Transcription_CREM signaling in testis
-
genes like me logo Genes that share pathways with H1-9P: view

Pathways by source for H1-9P Gene

1 GeneGo (Thomson Reuters) pathway for H1-9P Gene
  • Transcription_CREM signaling in testis

Interacting Proteins for H1-9P Gene

Gene Ontology (GO) - Biological Process for H1-9P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006338 chromatin remodeling NAS 12920187
GO:0006342 chromatin silencing IDA 12920187
GO:0006355 regulation of transcription, DNA-templated NAS 12920187
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with H1-9P: view

No data available for SIGNOR curated interactions for H1-9P Gene

Drugs & Compounds for H1-9P Gene

(1) Drugs for H1-9P Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with H1-9P: view

Transcripts for H1-9P Gene

mRNA/cDNA for H1-9P Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-9P

Alternative Splicing Database (ASD) splice patterns (SP) for H1-9P Gene

No ASD Table

Relevant External Links for H1-9P Gene

GeneLoc Exon Structure for
H1-9P

Expression for H1-9P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-9P

SOURCE GeneReport for Unigene cluster for H1-9P Gene:

Hs.25934

mRNA Expression by UniProt/SwissProt for H1-9P Gene:

P60008-HILS1_HUMAN
Tissue specificity: Expressed exclusively in the testis.

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-9P Gene

Orthologs for H1-9P Gene

Evolution for H1-9P Gene

ENSEMBL:
Gene Tree for H1-9P (if available)
TreeFam:
Gene Tree for H1-9P (if available)
Alliance of Genome Resources:
Additional Orthologs for H1-9P

No data available for Orthologs for H1-9P Gene

Paralogs for H1-9P Gene

No data available for Paralogs for H1-9P Gene

Variants for H1-9P Gene

Structural Variations from Database of Genomic Variants (DGV) for H1-9P Gene

Variant ID Type Subtype PubMed ID
nsv507842 OTHER sequence alteration 20534489
nsv952339 CNV deletion 24416366

Additional Variant Information for H1-9P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1-9P
Leiden Open Variation Database (LOVD)
H1-9P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for H1-9P Gene

Disorders for H1-9P Gene

Additional Disease Information for H1-9P

No disorders were found for H1-9P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H1-9P Gene

Publications for H1-9P Gene

  1. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. (PMID: 12920187) Yan W … Matzuk MM (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22
  2. Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements. (PMID: 30068355) Mishra LN … Rao MRS (Epigenetics & chromatin 2018) 2 3
  3. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P … Jagodzinski PP (Archives of andrology 2007) 3 22
  4. Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells. (PMID: 14636221) Iguchi N … Nishimune Y (International journal of andrology 2003) 3 22
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for H1-9P Gene

Sources for H1-9P Gene