Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for H1-8 Gene

Aliases for H1-8 Gene

  • H1.8 Linker Histone 2 3
  • H1 Histone Family Member O Oocyte Specific 2 3 5
  • Oocyte-Specific Linker Histone H1 3 4
  • Oocyte-Specific Histone H1 3 4
  • Histone H1oo 3 4
  • H1FOO 3 5
  • OsH1 3 4
  • H1 Histone Family, Member O, Oocyte-Specific 2
  • H1.8 3
  • H1oo 3
  • H1OO 4
  • OSH1 4

External Ids for H1-8 Gene

Previous HGNC Symbols for H1-8 Gene

  • H1FOO

Previous GeneCards Identifiers for H1-8 Gene

  • GC03P130161

Summaries for H1-8 Gene

Entrez Gene Summary for H1-8 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1-8 Gene

H1-8 (H1.8 Linker Histone) is a Protein Coding gene. Diseases associated with H1-8 include Cerebral Angioma and Brain Angioma. Among its related pathways are Cell cycle_Chromosome condensation in prometaphase and E2F mediated regulation of DNA replication. An important paralog of this gene is H1-4.

UniProtKB/Swiss-Prot Summary for H1-8 Gene

  • May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).

Gene Wiki entry for H1-8 Gene

Additional gene information for H1-8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-8 Gene

Genomics for H1-8 Gene

GeneHancer (GH) Regulatory Elements for H1-8 Gene

Promoters and enhancers for H1-8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J129543 Enhancer 0.3 Ensembl 500.7 +0.7 687 0.2 NR2F2 H1-8 lnc-TMCC1-9
GH03J129544 Enhancer 0.2 Ensembl 500.7 -0.1 -113 0.2 H1-8 RHO
GH03J129971 Enhancer 0.9 FANTOM5 ENCODE 13.7 +428.4 428429 0.4 ZNF217 CLOCK TCF7 SKI CTBP1 PCBP1 ESRRA FOXA2 ESR1 NEUROD1 lnc-TRH-3 H1-8 ENSG00000250643
GH03J129515 Enhancer 0.4 dbSUPER 12.7 -27.4 -27413 0.6 SAP130 CEBPG SP5 ZSCAN4 lnc-RHO-1 H1-8 PLXND1 lnc-PLXND1-2 IFT122
GH03J129103 Enhancer 0.4 FANTOM5 dbSUPER 15 -439.8 -439798 0.2 piR-34822-232 H1-8 piR-40901 RAB43 ISY1-RAB43
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H1-8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H1-8

Genomic Locations for H1-8 Gene

Genomic Locations for H1-8 Gene
chr3:129,543,214-129,551,467
(GRCh38/hg38)
Size:
8,254 bases
Orientation:
Plus strand
chr3:129,262,057-129,270,310
(GRCh37/hg19)
Size:
8,254 bases
Orientation:
Plus strand

Genomic View for H1-8 Gene

Genes around H1-8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1-8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1-8 Gene

Proteins for H1-8 Gene

  • Protein details for H1-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZA3-H1FOO_HUMAN
    Recommended name:
    Histone H1oo
    Protein Accession:
    Q8IZA3
    Secondary Accessions:
    • Q86WT7

    Protein attributes for H1-8 Gene

    Size:
    346 amino acids
    Molecular mass:
    35813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for H1-8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for H1-8 Gene

Post-translational modifications for H1-8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H1-8 Gene

No data available for DME Specific Peptides for H1-8 Gene

Domains & Families for H1-8 Gene

Gene Families for H1-8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H1-8 Gene

Blocks:
  • Histone H1/H5
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for H1-8 Gene

GenScript: Design optimal peptide antigens:
  • Oocyte-specific linker histone H1 (H1FOO_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZA3

UniProtKB/Swiss-Prot:

H1FOO_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1-8: view

Function for H1-8 Gene

Molecular function for H1-8 Gene

UniProtKB/Swiss-Prot Function:
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).

Phenotypes From GWAS Catalog for H1-8 Gene

Gene Ontology (GO) - Molecular Function for H1-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IBA 21873635
GO:0031492 nucleosomal DNA binding IBA,ISS --
genes like me logo Genes that share ontologies with H1-8: view
genes like me logo Genes that share phenotypes with H1-8: view

Animal Models for H1-8 Gene

MGI Knock Outs for H1-8:
  • H1f8 H1f8<tm1b(KOMP)Wtsi>
  • H1f8 H1f8<tm1Eya>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for H1-8 Gene

Localization for H1-8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1-8 Gene

Cytoplasm. Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H1-8 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for H1-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IBA,ISS --
GO:0005694 chromosome IEA --
GO:0005730 NOT nucleolus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with H1-8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H1-8 Gene

Pathways & Interactions for H1-8 Gene

PathCards logo

SuperPathways for H1-8 Gene

SuperPathway Contained pathways
1 E2F mediated regulation of DNA replication
.53
2 Cell cycle_Chromosome condensation in prometaphase
-
genes like me logo Genes that share pathways with H1-8: view

Pathways by source for H1-8 Gene

2 GeneGo (Thomson Reuters) pathways for H1-8 Gene
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle_Chromosome condensation in prometaphase

Gene Ontology (GO) - Biological Process for H1-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0016584 nucleosome positioning ISS --
GO:0030261 chromosome condensation IBA 21873635
GO:0031936 negative regulation of chromatin silencing IBA 21873635
genes like me logo Genes that share ontologies with H1-8: view

No data available for SIGNOR curated interactions for H1-8 Gene

Drugs & Compounds for H1-8 Gene

No Compound Related Data Available

Transcripts for H1-8 Gene

mRNA/cDNA for H1-8 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1-8 Gene

No ASD Table

Relevant External Links for H1-8 Gene

GeneLoc Exon Structure for
H1-8

Expression for H1-8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-8

SOURCE GeneReport for Unigene cluster for H1-8 Gene:

Hs.97358

mRNA Expression by UniProt/SwissProt for H1-8 Gene:

Q8IZA3-H1FOO_HUMAN
Tissue specificity: Oocyte-specific.

Evidence on tissue expression from TISSUES for H1-8 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with H1-8: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-8 Gene

Orthologs for H1-8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for H1-8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H1FOO 31 30
  • 98.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia H1FOO 31 30
  • 76.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia H1FOO 31 30
  • 75.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia H1foo 31 30
  • 65.64 (n)
OneToOne
H1f8 17
rat
(Rattus norvegicus)
Mammalia H1foo 30
  • 64.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia H1FOO 31
  • 33 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia H1FOO 31
  • 16 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii h1m 31
  • 23 (a)
OneToOne
Species where no ortholog for H1-8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for H1-8 Gene

ENSEMBL:
Gene Tree for H1-8 (if available)
TreeFam:
Gene Tree for H1-8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H1-8: view image

Paralogs for H1-8 Gene

Paralogs for H1-8 Gene

Pseudogenes.org Pseudogenes for H1-8 Gene

genes like me logo Genes that share paralogs with H1-8: view

Variants for H1-8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H1-8 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs59415528 - p.Asn296Ser

Additional dbSNP identifiers (rs#s) for H1-8 Gene

Structural Variations from Database of Genomic Variants (DGV) for H1-8 Gene

Variant ID Type Subtype PubMed ID
dgv4858n100 CNV gain 25217958
dgv4859n100 CNV gain 25217958
nsv508953 CNV insertion 20534489
nsv522149 CNV loss 19592680
nsv955346 CNV deletion 24416366

Variation tolerance for H1-8 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H1-8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1-8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1-8 Gene

Disorders for H1-8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for H1-8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral angioma
  • hemangioma of cerebrum
brain angioma
  • brain hemangioma
- elite association - COSMIC cancer census association via MalaCards
Search H1-8 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with H1-8: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for H1-8 Gene

Publications for H1-8 Gene

  1. Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte. (PMID: 12711322) Tanaka Y … Yoshimura Y (Biochemical and biophysical research communications 2003) 3 4 23 54
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 54
  3. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 54
  4. Histone variants: key players of chromatin. (PMID: 24781148) Biterge B … Schneider R (Cell and tissue research 2014) 3 54
  5. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. (PMID: 24614311) Maze I … Allis CD (Nature reviews. Genetics 2014) 3 54

Products for H1-8 Gene

Sources for H1-8 Gene