Aliases for H1-8 Gene
External Ids for H1-8 Gene
Previous HGNC Symbols for H1-8 Gene
Previous GeneCards Identifiers for H1-8 Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]
GeneCards Summary for H1-8 Gene
H1-8 (H1.8 Linker Histone) is a Protein Coding gene. Diseases associated with H1-8 include Cerebral Angioma and Brain Angioma. Among its related pathways are Cell cycle_Chromosome condensation in prometaphase and E2F mediated regulation of DNA replication. An important paralog of this gene is H1-4.
UniProtKB/Swiss-Prot Summary for H1-8 Gene
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).