Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for H1-7 Gene

Aliases for H1-7 Gene

  • H1.7 Linker Histone 2 3
  • H1 Histone Family Member N, Testis Specific 2 3 5
  • Haploid Germ Cell-Specific Nuclear Protein 1 3 4
  • Testis-Specific H1 Histone 3 4
  • Histone H1t2 3 4
  • H1FNT 3 5
  • HANP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 223n 3
  • H1 Histone Family, Member N, Testis-Specific 2
  • H1.7 3
  • H1T2 3

External Ids for H1-7 Gene

Previous HGNC Symbols for H1-7 Gene

  • H1FNT

Summaries for H1-7 Gene

Entrez Gene Summary for H1-7 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1-7 Gene

H1-7 (H1.7 Linker Histone) is a Protein Coding gene. An important paralog of this gene is H1-5.

UniProtKB/Swiss-Prot Summary for H1-7 Gene

  • Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.

Additional gene information for H1-7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-7 Gene

Genomics for H1-7 Gene

GeneHancer (GH) Regulatory Elements for H1-7 Gene

Promoters and enhancers for H1-7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H1-7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for H1-7 Gene

Genomic Locations for H1-7 Gene
chr12:48,328,980-48,330,279
(GRCh38/hg38)
Size:
1,300 bases
Orientation:
Plus strand
chr12:48,722,763-48,724,062
(GRCh37/hg19)
Size:
1,300 bases
Orientation:
Plus strand

Genomic View for H1-7 Gene

Genes around H1-7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1-7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1-7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1-7 Gene

Proteins for H1-7 Gene

  • Protein details for H1-7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75WM6-H1FNT_HUMAN
    Recommended name:
    Testis-specific H1 histone
    Protein Accession:
    Q75WM6
    Secondary Accessions:
    • Q147U8
    • Q5GKZ5
    • Q7Z694

    Protein attributes for H1-7 Gene

    Size:
    255 amino acids
    Molecular mass:
    28116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD13382.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for H1-7 Gene

Post-translational modifications for H1-7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H1-7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1-7 Gene

Domains & Families for H1-7 Gene

Gene Families for H1-7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H1-7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for H1-7 Gene

GenScript: Design optimal peptide antigens:
  • Histone H1t2 (H1FNT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q75WM6

UniProtKB/Swiss-Prot:

H1FNT_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1-7: view

Function for H1-7 Gene

Molecular function for H1-7 Gene

UniProtKB/Swiss-Prot Function:
Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.

Phenotypes From GWAS Catalog for H1-7 Gene

Gene Ontology (GO) - Molecular Function for H1-7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IBA 21873635
GO:0005524 ATP binding IEA --
GO:0031492 nucleosomal DNA binding IBA 21873635
genes like me logo Genes that share ontologies with H1-7: view
genes like me logo Genes that share phenotypes with H1-7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H1-7 Gene

Localization for H1-7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1-7 Gene

Nucleus. Chromosome. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250 UniProtKB:Q8CJI4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H1-7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for H1-7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS,IBA 15710904
GO:0005634 nucleus IBA 21873635
GO:0005694 chromosome IEA --
GO:0005719 nuclear euchromatin IBA 21873635
genes like me logo Genes that share ontologies with H1-7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H1-7 Gene

Pathways & Interactions for H1-7 Gene

PathCards logo

SuperPathways for H1-7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for H1-7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IBA 21873635
GO:0007290 spermatid nucleus elongation ISS 15710904
GO:0016584 nucleosome positioning IBA 21873635
genes like me logo Genes that share ontologies with H1-7: view

No data available for Pathways by source and SIGNOR curated interactions for H1-7 Gene

Drugs & Compounds for H1-7 Gene

No Compound Related Data Available

Transcripts for H1-7 Gene

mRNA/cDNA for H1-7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1-7 Gene

No ASD Table

Relevant External Links for H1-7 Gene

GeneLoc Exon Structure for
H1-7
ECgene alternative splicing isoforms for
H1-7

Expression for H1-7 Gene

NURSA nuclear receptor signaling pathways regulating expression of H1-7 Gene:

H1-7

SOURCE GeneReport for Unigene cluster for H1-7 Gene:

Hs.155833

mRNA Expression by UniProt/SwissProt for H1-7 Gene:

Q75WM6-H1FNT_HUMAN
Tissue specificity: Testis-specific.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-7 Gene

Orthologs for H1-7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for H1-7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H1FNT 33 32
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609303 32
  • 73.44 (n)
H1FNT 33
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC784038 32
  • 72.15 (n)
mouse
(Mus musculus)
Mammalia H1fnt 33
  • 32 (a)
OneToOne
Species where no ortholog for H1-7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H1-7 Gene

ENSEMBL:
Gene Tree for H1-7 (if available)
TreeFam:
Gene Tree for H1-7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H1-7: view image

Paralogs for H1-7 Gene

Paralogs for H1-7 Gene

genes like me logo Genes that share paralogs with H1-7: view

Variants for H1-7 Gene

Sequence variations from dbSNP and Humsavar for H1-7 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000417144 -- 48,330,441(+) A/G downstream_transcript_variant
rs1000650905 -- 48,328,320(+) G/A upstream_transcript_variant
rs1001919887 -- 48,329,736(+) G/C coding_sequence_variant, missense_variant
rs1003343737 -- 48,328,407(+) A/C upstream_transcript_variant
rs1003443892 -- 48,328,088(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for H1-7 Gene

Variant ID Type Subtype PubMed ID
esv2759898 CNV gain+loss 17122850
esv34439 CNV gain 17911159
esv3629436 CNV gain 21293372
nsv1160031 CNV deletion 26073780
nsv437752 CNV loss 16327808
nsv826362 CNV gain 20364138
nsv832402 CNV gain 17160897
nsv8971 CNV gain+loss 18304495

Variation tolerance for H1-7 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H1-7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1-7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1-7 Gene

Disorders for H1-7 Gene

No disorders were found for H1-7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for H1-7 Gene

Publications for H1-7 Gene

  1. Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. (PMID: 16533358) Tanaka H … Nishimune Y (International journal of andrology 2006) 3 4 23 56
  2. Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. (PMID: 15710904) Martianov I … Davidson I (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 56
  5. Histone variants: key players of chromatin. (PMID: 24781148) Biterge B … Schneider R (Cell and tissue research 2014) 3 56

Products for H1-7 Gene

Sources for H1-7 Gene