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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H1-6 (H1.6 Linker Histone, Cluster Member) is a Protein Coding gene. Diseases associated with H1-6 include Timothy Grass Allergy. Among its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway. An important paralog of this gene is H1-4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
GO:0031492 | nucleosomal DNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005694 | chromosome | IEA | -- |
GO:0005719 | nuclear euchromatin | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Granzyme-A Pathway |
Granzyme-A Pathway
-
|
|
2 | Activation of cAMP-Dependent PKA |
PKA Signaling
.56
|
|
3 | E2F mediated regulation of DNA replication |
Cell cycle Start of DNA replication in early S phase
.53
|
|
4 | Cell cycle_Chromosome condensation in prometaphase |
Cell cycle_Chromosome condensation in prometaphase
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006334 | nucleosome assembly | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007283 | spermatogenesis | TAS,IBA | 21873635 |
GO:0016584 | nucleosome positioning | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471879 30 |
|
||
HIST1H1T 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | HIST1H1T 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hist1h1t 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hist1h1t 30 31 |
|
OneToOne | |
H1f6 17 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | HIST1H111R 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732947 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:163061 30 31 31 |
|
ManyToMany | |
CABZ01086354.1 31 |
|
ManyToMany | |||
CU457819.3 31 |
|
ManyToMany | |||
FP325123.1 31 |
|
ManyToMany | |||
zgc:110425 31 |
|
ManyToMany | |||
histh1l 31 |
|
ManyToMany | |||
si:dkey-261m9.12 31 |
|
ManyToMany | |||
si:ch211-113a14.24 31 |
|
ManyToMany | |||
si:dkey-108k21.14 31 |
|
ManyToMany | |||
zgc:153405 31 |
|
ManyToMany | |||
si:ch211-113a14.18 31 |
|
ManyToMany | |||
si:dkey-108k21.10 31 |
|
ManyToMany | |||
si:ch211-113a14.12 31 |
|
ManyToMany | |||
si:dkey-108k21.21 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
esv3608393 | CNV | gain | 21293372 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
timothy grass allergy |
|
|