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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H1-5 (H1.5 Linker Histone, Cluster Member) is a Protein Coding gene. Diseases associated with H1-5 include Frontometaphyseal Dysplasia 2 and Tonsil Squamous Cell Carcinoma. Among its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway. An important paralog of this gene is H1-4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 26496610 |
GO:0031490 | chromatin DNA binding | IMP | 15911621 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA,IDA | 19882353 |
GO:0005634 | nucleus | IBA,IDA | 21383955 |
GO:0005694 | chromosome | IEA | -- |
GO:0005719 | nuclear euchromatin | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic execution phase |
.31
|
|
2 | Apoptosis induced DNA fragmentation | ||
3 | Cellular Senescence (REACTOME) | ||
4 | DNA Damage/Telomere Stress Induced Senescence | ||
5 | Granzyme-A Pathway |
Granzyme-A Pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 22956909 |
GO:0006325 | chromatin organization | IMP | 22956909 |
GO:0006334 | nucleosome assembly | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
GO:0007517 | muscle organ development | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1B 31 |
|
OneToOne | |
LOC471906 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Hist1h1b 31 |
|
OneToMany | |
Gm6970 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | LOC488305 30 |
|
||
Cow (Bos Taurus) |
Mammalia | HIST1H1D 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | HIST1H111L 31 |
|
ManyToMany | |
HIST1H111R 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8334 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CU457819.3 31 |
|
ManyToMany | |
CABZ01086354.1 31 |
|
ManyToMany | |||
histh1l 31 |
|
ManyToMany | |||
FP325123.1 31 |
|
ManyToMany | |||
si:dkey-261m9.12 31 |
|
ManyToMany | |||
zgc:153405 31 |
|
ManyToMany | |||
zgc:110425 31 |
|
ManyToMany | |||
si:ch211-113a14.24 31 |
|
ManyToMany | |||
si:ch211-113a14.18 31 |
|
ManyToMany | |||
si:dkey-108k21.14 31 |
|
ManyToMany | |||
si:ch211-113a14.12 31 |
|
ManyToMany | |||
si:dkey-108k21.10 31 |
|
ManyToMany | |||
zgc:163061 31 31 |
|
ManyToMany | |||
si:dkey-108k21.21 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036204 | A colorectal cancer sample | p.Gly86Asp | |||
rs11970638 | - | p.Lys144Arg | |||
rs34144478 | - | p.Ala211Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
frontometaphyseal dysplasia 2 |
|
|
tonsil squamous cell carcinoma |
|
|
frontometaphyseal dysplasia 1 |
|
|