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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in ... See more...
Aliases for H1-4 Gene
Aliases for H1-4 Gene
External Ids for H1-4 Gene
- HGNC: 4718
- Entrez Gene: 3008
- Ensembl: ENSG00000168298
- OMIM: 142220
- UniProtKB: P10412
Previous HGNC Symbols for H1-4 Gene
- H1F4
- HIST1H1E
Previous GeneCards Identifiers for H1-4 Gene
- GC06P027643
- GC06P028369
Summaries for H1-4 Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for H1-4 Gene
H1-4 (H1.4 Linker Histone, Cluster Member) is a Protein Coding gene. Diseases associated with H1-4 include Rahman Syndrome and Helsmoortel-Van Der Aa Syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Signaling events mediated by HDAC Class III. An important paralog of this gene is H1-5.
UniProtKB/Swiss-Prot Summary for H1-4 Gene
-
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Additional gene information for H1-4 Gene
- HGNC(4718)
- Entrez Gene(3008)
- Ensembl(ENSG00000168298)
- OMIM(142220)
- UniProtKB(P10412)
- Open Targets Platform(ENSG00000168298)
- Monarch Initiative
- Search for H1-4 at DataMed
- Search for H1-4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-4 Gene
Genomics for H1-4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H1-4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H1-4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H1-4
Genomic Locations for H1-4 Gene
Genomic Locations for H1-4 Gene
- chr6:26,156,329-26,157,115
- (GRCh38/hg38)
- Size:
- 787 bases
- Orientation:
- Plus strand
- chr6:26,156,559-26,157,343
- (GRCh37/hg19)
- Size:
- 785 bases
- Orientation:
- Plus strand
Genomic View for H1-4 Gene
Genes around H1-4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H1-4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H1-4 Gene
Proteins for H1-4 Gene
-
Protein details for H1-4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10412-H14_HUMAN
- Recommended name:
- Histone H1.4
- Protein Accession:
- P10412
- Q4VB25
Protein attributes for H1-4 Gene
- Size:
- 219 amino acids
- Molecular mass:
- 21865 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- This variant accounts for 60% of histone H1.
Post-translational modifications for H1-4 Gene
- H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
- Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
- Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
- ADP-ribosylated on Ser-150 in response to DNA damage.
-
Ubiquitination at Lys17
- NX_P10412 (NX_P10412-1)
- Modification sites at PhosphoSitePlus
Other Protein References for H1-4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for H1-4
- Novus Biologicals Antibodies for H1-4
-
Abcam antibodies for H1-4
-
Boster Bio Antibodies for H1-4
Protein Products
-
OriGene Purified Proteins for H1-4
- Search Origene for MassSpec and Protein Over-expression Lysates for H1-4
- Origene Custom Protein Services for H1-4
- Novus Biologicals lysates for H1-4
No data available for DME Specific Peptides for H1-4 Gene
Domains & Families for H1-4 Gene
Gene Families for H1-4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for H1-4 Gene
- InterPro:
- Blocks:
-
- Histone H1/H5
- ProtoNet:
Suggested Antigen Peptide Sequences for H1-4 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone H1e (A3R0T8_HUMAN)
- Histone H1b (H14_HUMAN)
- Histone cluster 1, H1e (Q4VB24_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P10412UniProtKB/Swiss-Prot:
H14_HUMAN :- The C-terminal domain is required for high-affinity binding to chromatin.
- Belongs to the histone H1/H5 family.
- Domain:
-
- The C-terminal domain is required for high-affinity binding to chromatin.
- Family:
-
- Belongs to the histone H1/H5 family.
Function for H1-4 Gene
Molecular function for H1-4 Gene
- UniProtKB/Swiss-Prot Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Phenotypes From GWAS Catalog for H1-4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0005509 | calcium ion binding | IEA | -- |
Phenotypes for H1-4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H1-4 - Select products 50% OFF >
- * H1-4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for H1-4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H1-4
miRNA for H1-4 Gene
- miRTarBase miRNAs that target H1-4
-
- hsa-miR-34a-5p (MIRT025303)
- hsa-miR-1180-3p (MIRT035933)
- hsa-miR-877-3p (MIRT036815)
- hsa-miR-744-5p (MIRT037534)
- hsa-miR-455-3p (MIRT037853)
- hsa-miR-423-5p (MIRT038119)
- hsa-let-7g-3p (MIRT038661)
- hsa-miR-652-3p (MIRT039548)
- hsa-miR-193b-3p (MIRT041423)
- hsa-miR-331-3p (MIRT043395)
- hsa-miR-320a (MIRT044538)
- hsa-miR-186-5p (MIRT045006)
- hsa-miR-181b-5p (MIRT047253)
- hsa-miR-92a-3p (MIRT049232)
- hsa-miR-3147 (MIRT218415)
- hsa-miR-4263 (MIRT218416)
- hsa-miR-3620-5p (MIRT218418)
- hsa-miR-1587 (MIRT218421)
- hsa-miR-4674 (MIRT218422)
- hsa-miR-6792-5p (MIRT218424)
- hsa-miR-6815-3p (MIRT218425)
- hsa-miR-146a-3p (MIRT317223)
- hsa-miR-760 (MIRT317224)
- hsa-miR-1276 (MIRT317225)
- hsa-miR-3940-5p (MIRT317228)
- hsa-miR-4507 (MIRT317229)
- hsa-miR-8057 (MIRT317231)
- hsa-miR-5693 (MIRT523280)
- hsa-miR-6839-3p (MIRT523281)
- hsa-miR-4425 (MIRT523282)
- hsa-miR-6748-5p (MIRT523283)
- hsa-miR-6769b-5p (MIRT523284)
- hsa-miR-6769a-5p (MIRT523285)
- hsa-miR-4483 (MIRT523286)
- hsa-miR-1293 (MIRT523287)
- hsa-miR-6766-5p (MIRT523288)
- hsa-miR-6756-5p (MIRT523289)
- hsa-miR-6745 (MIRT523290)
- hsa-miR-363-5p (MIRT523291)
- hsa-miR-27a-5p (MIRT523292)
- hsa-miR-6822-3p (MIRT523293)
- hsa-miR-4766-5p (MIRT523294)
- hsa-miR-6786-5p (MIRT523295)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H1-4
- Browse OriGene Inhibitory RNA Products For H1-4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-4
Clone Products
- Applied Biological Materials (abm): Clones for H1-4 - Select products 50% OFF >
- * H1-4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H1-4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H1-4
Cell Line Products
-
Horizon Cell Lines for H1-4
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for H1-4 Gene
Localization for H1-4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H1-4 Gene
- Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000788 | nuclear nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA | 21873635 |
| GO:0005634 | nucleus | IBA,IDA | 17540172 |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for H1-4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic execution phase |
.31
|
|
| 2 | Apoptosis induced DNA fragmentation | ||
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Chromatin Regulation / Acetylation | ||
Pathways by source for H1-4 Gene
2 BioSystems pathways for H1-4 Gene
9 Reactome pathways for H1-4 Gene
2 GeneGo (Thomson Reuters) pathways for H1-4 Gene
- Cell cycle Start of DNA replication in early S phase
- Cell cycle_Chromosome condensation in prometaphase
2 Qiagen pathways for H1-4 Gene
- Granzyme-A Pathway
- PKA Signaling
1 Cell Signaling Technology pathway for H1-4 Gene
Interacting Proteins for H1-4 Gene
Selected Interacting proteins:
P10412-H14_HUMAN
ENSP00000307705
for H1-4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H1-4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0016584 | nucleosome positioning | IBA | 21873635 |
No data available for SIGNOR curated interactions for H1-4 Gene
Drugs & Compounds for H1-4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 249 |
Transcripts for H1-4 Gene
mRNA/cDNA for H1-4 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000304218 787 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H1-4 - Select products 50% OFF >
- * H1-4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H1-4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H1-4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H1-4
- Browse OriGene Inhibitory RNA Products For H1-4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-4
Clone Products
- Applied Biological Materials (abm): Clones for H1-4 - Select products 50% OFF >
- * H1-4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H1-4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H1-4
Relevant External Links for H1-4 Gene
- GeneLoc Exon Structure for
- H1-4
Expression for H1-4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-4
SOURCE GeneReport for Unigene cluster for H1-4 Gene:
Hs.248133Evidence on tissue expression from TISSUES for H1-4 Gene
- Liver(4.7)
- Spleen(4.5)
- Nervous system(3.9)
- Intestine(3.8)
- Muscle(3.8)
- Stomach(3.7)
- Kidney(3.7)
- Heart(3.4)
- Skin(2.8)
- Lung(2.4)
- Bone marrow(2.3)
- Blood(2.2)
- Lymph node(2.2)
- Pancreas(2.1)
- Thyroid gland(2)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for H1-4
-
OriGene qPCR primer pairs and template standards for H1-4
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-4 Gene
Orthologs for H1-4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1E 31 |
|
OneToOne | |
| LOC471881 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | HIST1H1E 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hist1h1e 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HIST1H1E 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | HIST1H111L 31 |
|
ManyToMany | |
| HIST1H111R 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.806 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.494 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CU457819.3 31 |
|
ManyToMany | |
| CABZ01086354.1 31 |
|
ManyToMany | |||
| si:ch211-113a14.12 31 |
|
ManyToMany | |||
| FP325123.1 31 |
|
ManyToMany | |||
| zgc:153405 31 |
|
ManyToMany | |||
| si:dkey-261m9.12 31 |
|
ManyToMany | |||
| si:ch211-113a14.24 31 |
|
ManyToMany | |||
| si:ch211-113a14.18 31 |
|
ManyToMany | |||
| si:dkey-108k21.14 31 |
|
ManyToMany | |||
| si:dkey-108k21.10 31 |
|
ManyToMany | |||
| zgc:163061 31 31 |
|
ManyToMany | |||
| zgc:110425 31 |
|
ManyToMany | |||
| histh1l 31 |
|
ManyToMany | |||
| si:dkey-108k21.21 31 |
|
ManyToMany | |||
| -- 30 |
|
- Species where no ortholog for H1-4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for H1-4 Gene
- ENSEMBL:
- Gene Tree for H1-4 (if available)
- TreeFam:
- Gene Tree for H1-4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H1-4: view image
Paralogs for H1-4 Gene
Variants for H1-4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H1-4 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 635256 | Pathogenic/Likely Pathogenic: RAHMAN SYNDROME | 26,156,797(+) | A/AG | FRAMESHIFT_VARIANT | |
| 635257 | Pathogenic: RAHMAN SYNDROME | 26,156,801(+) | G/GC | FRAMESHIFT_VARIANT | |
| 635258 | Pathogenic: RAHMAN SYNDROME | 26,156,815(+) | CGGGGGC/AGGGGGTT | ||
| 635259 | Pathogenic: RAHMAN SYNDROME | 26,156,815(+) | C/AG | FRAMESHIFT_VARIANT | |
| 635260 | Pathogenic: RAHMAN SYNDROME | 26,156,836(+) | A/AG | FRAMESHIFT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608394 | CNV | loss | 21293372 |
| esv3608395 | CNV | gain | 21293372 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.29;
40.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H1-4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H1-4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1-4 Gene
Disorders for H1-4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rahman syndrome |
|
|
| helsmoortel-van der aa syndrome |
|
|
| cerebellar ataxia, deafness, and narcolepsy, autosomal dominant |
|
|
| weaver syndrome |
|
|
Search H1-4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
H14_HUMAN- Rahman syndrome (RMNS) [MIM:617537]: An autosomal dominant syndrome characterized by intellectual disability and overgrowth manifesting as increased birth length, height, weight, and/or head circumference. {ECO:0000269 PubMed:28475857}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for H1-4
No data available for Genatlas for H1-4 Gene
Publications for H1-4 Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W … Doenecke D (Genomics 1991) 2 3 4
- Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability. (PMID: 28475857) Tatton-Brown K … Rahman N (American journal of human genetics 2017) 3 4
- L3MBTL1, a histone-methylation-dependent chromatin lock. (PMID: 17540172) Trojer P … Reinberg D (Cell 2007) 3 23
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
ExternalLinks
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- VectorBuilder Custom and pre-made DNA vectors for H1-4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H1-4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for H1-4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for H1-4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H1-4
- antibodies-online: Search results for available Histone H1.4 related products ranked by validation data
- antibodies-online: Search results for available Histone H1.4 related products ranked by validation data
- antibodies-online: Search results for available Histone H1.4 related products ranked by validation data
- Horizon Cell Lines for H1-4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H1-4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H1-4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H1-4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-4
Sources for H1-4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB