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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H1-3 (H1.3 Linker Histone, Cluster Member) is a Protein Coding gene. Diseases associated with H1-3 include Ovarian Cancer. Among its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway. An important paralog of this gene is H1-4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0031490 | chromatin DNA binding | IDA | 15911621 |
GO:0031492 | nucleosomal DNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IBA,IDA | 19882353 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005694 | chromosome | IEA | -- |
GO:0005719 | nuclear euchromatin | IBA,IDA | 15911621 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic execution phase |
.31
|
|
2 | Apoptosis induced DNA fragmentation | ||
3 | Cellular Senescence (REACTOME) | ||
4 | DNA Damage/Telomere Stress Induced Senescence | ||
5 | Granzyme-A Pathway |
Granzyme-A Pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006334 | nucleosome assembly | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0016584 | nucleosome positioning | IEA,IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1D 31 |
|
OneToOne | |
LOC472227 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | HIST1H1E 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC611113 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Hist1h1d 30 31 |
|
OneToOne | |
H1f3 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | HIST1H111L 31 |
|
ManyToMany | |
HIST1H111R 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | CU457819.3 31 |
|
ManyToMany | |
CABZ01086354.1 31 |
|
ManyToMany | |||
zgc:163061 31 31 |
|
ManyToMany | |||
si:ch211-113a14.12 31 |
|
ManyToMany | |||
zgc:110425 31 |
|
ManyToMany | |||
zgc:153405 31 |
|
ManyToMany | |||
FP325123.1 31 |
|
ManyToMany | |||
si:dkey-261m9.12 31 |
|
ManyToMany | |||
si:ch211-113a14.24 31 |
|
ManyToMany | |||
si:ch211-113a14.18 31 |
|
ManyToMany | |||
histh1l 31 |
|
ManyToMany | |||
si:dkey-108k21.10 31 |
|
ManyToMany | |||
si:dkey-108k21.14 31 |
|
ManyToMany | |||
si:dkey-108k21.21 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5926n100 | CNV | gain | 25217958 |
nsv1021294 | CNV | loss | 25217958 |
nsv1023453 | CNV | gain | 25217958 |
nsv428137 | CNV | loss | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|